scholarly journals Correlation analysis of mRNA expression and prognosis of hOGG1 gene polymorphism in patients with non-small cell lung cancer

2019 ◽  
Author(s):  
Jing Wang ◽  
Puzhao Wu
Keyword(s):  
Lung Cancer ◽  
Correlation Analysis ◽  
Gene Polymorphism ◽  
Small Cell Lung Cancer ◽  
Mrna Expression ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Hogg1 Gene

scholarly journals The prognostic value of 4.1 mRNA expression in non-small cell lung cancer

2021 ◽  
Vol 10 (3) ◽  
pp. 1216-1228
Author(s):  
Yuying Xiang ◽  
Feiyu Shan ◽  
Guan Feng ◽  
Kaibo Guo ◽  
Shanming Ruan ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Mrna Expression ◽  
Cell Lung Cancer ◽  
Prognostic Value ◽  
Small Cell ◽  
Small Cell Lung

scholarly journals Circulating mRNA Expression of astrocyte-Elevated Gene-1 Associated with Treatment Response and Survival in Non-Small Cell Lung Cancer Patients Treated with Pemetrexed

2021 ◽  
Author(s):  
You-Lung Chang ◽  
Yen-Fu Chen ◽  
Ying-Yin Chen ◽  
Shih-Chieh Chang ◽  
Cheng-Yu Chang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Mrna Expression ◽  
Treatment Response ◽  
Cell Lung Cancer ◽  
Advanced Nsclc ◽  
Small Cell ◽  
Small Cell Lung ◽  
Cox Regression Analysis ◽  
Nsclc Patients

Abstract Backgrounds: Astrocyte-elevated gene-1 (AEG-1) functions as an oncogene and regulates angiogenesis in non-small cell lung cancer (NSCLC). In this prospective study, we assessed the values of plasma AEG-1 mRNA expression by liquid biopsy associated with tumor response and survival in NSCLC patients treated with pemetrexed. Methods: Patients diagnosed advanced NSCLC were enrolled to be treated with pemetrexed combined platinum as first-line chemotherapy. All patients underwent blood sampling before any cancer treatment (C0) and at first response evaluation after two cycles (C2) treatments. Response to chemotherapy and survival were assessed. Plasma mRNA was extracted from peripheral blood mononuclear cell (PBMC) and quantification of RNA was performed by real-time PCR.Results: A total of 50 patients with advanced NSCLC were included and 13 of 50 patients combined with bevacizumab. In patient groups of SD (n = 13) and PD (n = 10), the plasma mRNA of AEG-1, thymidylate synthase (TS) and CK19 were elevated significantly at C2 compared to patients in treatment response group (PR, n = 27) (PR v.s. SD or PD, AEG-1: 1.22 ± 0.80 v.s. 4.51 ± 15.45, p = 0.043). NSCLC patients had elevated AEG-1 (AEG-1 ≥ 2) after 2-cycle chemotherapy had shorter PFS and OS (high AEG-1 v.s. low AEG-1, median, PFS: 5.5 v.s. 11.9 months, p = 0.021; OS: 25.9 v.s. 40.8 months, p = 0.019, respectively). In Cox regression analysis, increased plasma mRNA expression of AEG-1indicated poor prognosis in survival.Conclusion: Circulating mRNA concentration of AEG-1 could be a predictive and prognostic biomarker in NSCLC patients treated with pemetrexed. Increased expression of AEG-1 contributed to the chemoresistance and caused lung cancer progression.

scholarly journals Investigation of Caspase 9 Gene Polymorphism in Patients With Non-small Cell Lung Cancer

2019 ◽  
Vol 39 (5) ◽  
pp. 2437-2441 ◽  
Author(s):  
SINA ERCAN ◽  
SIBEL ARINC ◽  
SEDA GULEC YILMAZ ◽  
CIGDEM ALTUNOK ◽  
FERIDE YAMAN ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Gene Polymorphism ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Caspase 9

scholarly journals BRCA1, LMO4, and CtIP mRNA Expression in Erlotinib-Treated Non–Small-Cell Lung Cancer Patients with EGFR Mutations

2013 ◽  
Vol 8 (3) ◽  
pp. 295-300 ◽  
Author(s):  
Niki Karachaliou ◽  
Carlota Costa ◽  
Ana Gimenez-Capitan ◽  
Miguel Angel Molina-Vila ◽  
Jordi Bertran-Alamillo ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Mrna Expression ◽  
Cancer Patients ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Egfr Mutations ◽  
Small Cell Lung ◽  
Lung Cancer Patients

Association of single nucleotide autophagy‐related protein 5 gene polymorphism rs2245214 with susceptibility to non–small cell lung cancer

2018 ◽  
Vol 120 (2) ◽  
pp. 1924-1931 ◽  
Author(s):  
Mohsen Nikseresht ◽  
Maryam Shahverdi ◽  
Mehdi Dehghani ◽  
Hassan Abidi ◽  
Reza Mahmoudi ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Gene Polymorphism ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Related Protein ◽  
Small Cell Lung ◽  
Single Nucleotide
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