scholarly journals Lung cancer cells release high mobility group box 1 and promote the formation of neutrophil extracellular traps

2019 ◽  
Author(s):  
Jiawei Zhou ◽  
Yonglin Yang ◽  
Tingting Gan ◽  
Yan Li ◽  
Fan Hu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
High Mobility ◽  
Neutrophil Extracellular Traps ◽  
High Mobility Group ◽  
Lung Cancer Cells ◽  
Extracellular Traps

Abstract 3738: IL-24 modulates the high mobility group (HMG) A1/miR222 /AKT signaling in lung cancer cells

2016 ◽  
Author(s):  
Janani Panneerselvam ◽  
Akhil Srivastava ◽  
Ranganayaki Muralidharan ◽  
Qi Wang ◽  
Wei Zheng ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
High Mobility ◽  
Akt Signaling ◽  
High Mobility Group ◽  
Lung Cancer Cells

scholarly journals Enhancement of Cisplatin Sensitivity in High Mobility Group 2 cDNA-transfected Human Lung Cancer Cells

1999 ◽  
Vol 90 (1) ◽  
pp. 108-115 ◽  
Author(s):  
Hitoshi Arioka ◽  
Kazuto Nishio ◽  
Tomoyuki Ishida ◽  
Hisaoh Fukumoto ◽  
Kazuya Fukuoka ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Human Lung ◽  
High Mobility ◽  
High Mobility Group ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Human Lung Cancer Cells ◽  
Cisplatin Sensitivity ◽  
Group 2

scholarly journals IL-24 modulates the high mobility group (HMG) A1/miR222 /AKT signaling in lung cancer cells

Oncotarget ◽  
2016 ◽  
Vol 7 (43) ◽  
pp. 70247-70263 ◽  
Author(s):  
Janani Panneerselvam ◽  
Akhil Srivastava ◽  
Ranganayaki Muralidharan ◽  
Qi Wang ◽  
Wei Zheng ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
High Mobility ◽  
Akt Signaling ◽  
High Mobility Group ◽  
Lung Cancer Cells

High-mobility group A1 proteins enhance the expression of the oncogenic miR-222 in lung cancer cells

2011 ◽  
Vol 357 (1-2) ◽  
pp. 363-371 ◽  
Author(s):  
Yunzhi Zhang ◽  
Teng Ma ◽  
Shuping Yang ◽  
Mingying Xia ◽  
Jing Xu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
High Mobility ◽  
High Mobility Group ◽  
Lung Cancer Cells

scholarly journals Apelin-mediated deamidation modification of HMGA1 promotes tumorigenesis by enhancing SRBEP1 activity and Lipid Synthesis

2020 ◽  
Author(s):  
Li Zhang ◽  
Yihan Zhu ◽  
Ying Yang ◽  
Hong Bu ◽  
Hong Huang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Lipid Metabolism ◽  
Cancer Cells ◽  
Molecular Mechanisms ◽  
Protein Complexes ◽  
Regulatory Element ◽  
Lipid Synthesis ◽  
High Mobility ◽  
Lung Cancer Cells ◽  
Abnormal Lipid Metabolism

Abstract Apelin is a ligand of the G protein-coupled receptor that promotes tumor growth in malignant cancers. However, the molecular mechanisms through which apelin promotes tumorigenesis are unknown. Here, we confirmed that apelin promotes tumorigenesis in lung cancer cells by increasing the synthesis of fatty acids, which induces abnormal lipid metabolism. Apelin interacts with high-mobility group A HMGA1 and mediates sterol-regulatory-element-binding protein 1 (SREBP1) activity, which is required for lung tumorigenesis and lipid metabolism. Deamidation modification of HMGA1 is regulated by apelin enhanced SRBEP1 activity and lipid synthesis. Moreover, deamidated HMGA1 can enhance the formation of the apelin-HMGA1-SREBP1 complexes and increases SREBP1 activity, which induces abnormal lipid metabolism. As an energy regulator, Apelin forms a multi-protein complexes with HMGA1 to increase of lung cancer cells viability. Our results indicate that apelin is important in lipid metabolism and cancer cell proliferation.

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