scholarly journals Alantolactone induces gastric cancer BGC‑823 cell apoptosis by regulating reactive oxygen species generation and the AKT signaling pathway

2019 ◽  
Author(s):  
Xin Zhang ◽  
Hong‑Ming Zhang
Keyword(s):  
Gastric Cancer ◽  
Reactive Oxygen Species ◽  
Signaling Pathway ◽  
Cell Apoptosis ◽  
Reactive Oxygen Species Generation ◽  
Reactive Oxygen ◽  
Akt Signaling ◽  
Oxygen Species ◽  
Akt Signaling Pathway

scholarly journals Protective Effects of Gintonin on Reactive Oxygen Species-Induced HT22 Cell Damages: Involvement of LPA1 Receptor-BDNF-AKT Signaling Pathway

Molecules ◽  
2021 ◽  
Vol 26 (14) ◽  
pp. 4138
Author(s):  
Yeon-Jin Cho ◽  
Sun-Hye Choi ◽  
Ra-Mi Lee ◽  
Han-Sung Cho ◽  
Hyewhon Rhim ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Signaling Pathway ◽  
Reactive Oxygen ◽  
Akt Signaling ◽  
Atp Depletion ◽  
Oxygen Species ◽  
Akt Signaling Pathway ◽  
Neuroprotective Effects ◽  
Lpa1 Receptor

Gintonin is a kind of ginseng-derived glycolipoprotein that acts as an exogenous LPA receptor ligand. Gintonin has in vitro and in vivo neuroprotective effects; however, little is known about the cellular mechanisms underlying the neuroprotection. In the present study, we aimed to clarify how gintonin attenuates iodoacetic acid (IAA)-induced oxidative stress. The mouse hippocampal cell line HT22 was used. Gintonin treatment significantly attenuated IAA-induced reactive oxygen species (ROS) overproduction, ATP depletion, and cell death. However, treatment with Ki16425, an LPA1/3 receptor antagonist, suppressed the neuroprotective effects of gintonin. Gintonin elicited [Ca2⁺]i transients in HT22 cells. Gintonin-mediated [Ca2⁺]i transients through the LPA1 receptor-PLC-IP3 signaling pathway were coupled to increase both the expression and release of BDNF. The released BDNF activated the TrkB receptor. Induction of TrkB phosphorylation was further linked to Akt activation. Phosphorylated Akt reduced IAA-induced oxidative stress and increased cell survival. Our results indicate that gintonin attenuated IAA-induced oxidative stress in neuronal cells by activating the LPA1 receptor-BDNF-TrkB-Akt signaling pathway. One of the gintonin-mediated neuroprotective effects may be achieved via anti-oxidative stress in nervous systems.

Increase in Reactive Oxygen Species and Activation of Akt Signaling Pathway in Neuropathic Pain

2008 ◽  
Vol 28 (8) ◽  
pp. 1049-1056 ◽  
Author(s):  
Renata P. Guedes ◽  
Alex S. R. Araújo ◽  
Daiane Janner ◽  
Adriane Belló-Klein ◽  
Maria Flávia M. Ribeiro ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Neuropathic Pain ◽  
Signaling Pathway ◽  
Reactive Oxygen ◽  
Akt Signaling ◽  
Oxygen Species ◽  
Akt Signaling Pathway

scholarly journals Reactive oxygen species induced by uric acid promote NRK‑52E cell apoptosis through the NEK7‑NLRP3 signaling pathway

2021 ◽  
Vol 24 (4) ◽  
Author(s):  
Dongdong Li ◽  
Luobing Wang ◽  
Jiaoying Ou ◽  
Chuanxu Wang ◽  
Jiabao Zhou ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Uric Acid ◽  
Signaling Pathway ◽  
Cell Apoptosis ◽  
Reactive Oxygen ◽  
Oxygen Species
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