scholarly journals Combination of metformin and paclitaxel suppresses proliferation and induces apoptosis of human prostate cancer cells via oxidative stress and targeting the mitochondria‑dependent pathway

2019 ◽  
Author(s):  
Yuwan Zhao ◽  
Xin Zeng ◽  
Huancheng Tang ◽  
Dongcai Ye ◽  
Jianjun Liu
Keyword(s):  
Oxidative Stress ◽  
Prostate Cancer ◽  
Cancer Cells ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells ◽  
Dependent Pathway

scholarly journals The curcumin analog ca27 down-regulates androgen receptor through an oxidative stress mediated mechanism in human prostate cancer cells

The Prostate ◽  
2011 ◽  
Vol 72 (6) ◽  
pp. 612-625 ◽  
Author(s):  
Alexandra M. Fajardo ◽  
Debra A. MacKenzie ◽  
Ming Ji ◽  
Lorraine M. Deck ◽  
David L. Vander Jagt ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Cells ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells ◽  
Curcumin Analog

scholarly journals Selective Anticancer Therapy Using Pro-Oxidant Drug-Loaded Chitosan–Fucoidan Nanoparticles

2019 ◽  
Vol 20 (13) ◽  
pp. 3220 ◽  
Author(s):  
Dae Gun Choi ◽  
Jayachandran Venkatesan ◽  
Min Suk Shim
Keyword(s):  
Oxidative Stress ◽  
Prostate Cancer ◽  
Cancer Cells ◽  
Water Solubility ◽  
Drug Carriers ◽  
Human Prostate ◽  
Ros Generation ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells

Pro-oxidant therapy exploiting pro-oxidant drugs that can trigger cytotoxic oxidative stress in cancer cells has emerged as an innovative strategy for cancer-specific therapy. Piperlongumine (PL) has gained great interest as a novel pro-oxidant agent, because it has an ability to trigger cancer-specific apoptosis through the increase of oxidative stress in cancer cells. However, the use of PL is limited in the clinic because of its hydrophobic nature. In this study, chitosan- and fucoidan-based nanoparticles were prepared for the effective intracellular delivery of PL into cancer cells. Chitosan and fucoidan formed nanoparticles by ionic gelation. The chitosan- and fucoidan-based nanoparticles (CS–F NPs) effectively encapsulated PL, and increased its water solubility and bioavailability. CS–F NPs showed very low cytotoxicity in human prostate cancer cells, demonstrating its high potential for in vivo applications. The PL-loaded chitosan–fucoidan nanoparticles (PL-CS–F NPs) efficiently killed human prostate cancer cells via PL-induced intracellular reactive oxygen species (ROS) generation. This study demonstrates that CS–F NPs are promising natural polymer-based drug carriers for safe and effective PL delivery.

scholarly journals 2-Deoxyglucose combined with wild-type p53 overexpression enhances cytotoxicity in human prostate cancer cells via oxidative stress

2008 ◽  
Vol 44 (5) ◽  
pp. 826-834 ◽  
Author(s):  
Iman M. Ahmad ◽  
Maher Y. Abdalla ◽  
Nukhet Aykin-Burns ◽  
Andrean L. Simons ◽  
Larry W. Oberley ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Prostate Cancer ◽  
Cancer Cells ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Wild Type ◽  
Prostate Cancer Cells ◽  
P53 Overexpression ◽  
Wild Type P53

JunD mediates androgen-induced oxidative stress in androgen dependent LNCaP human prostate cancer cells

The Prostate ◽  
2008 ◽  
Vol 68 (9) ◽  
pp. 924-934 ◽  
Author(s):  
Farideh Mehraein-Ghomi ◽  
Elyse Lee ◽  
Dawn R. Church ◽  
Todd A. Thompson ◽  
Hirak S. Basu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Prostate Cancer ◽  
Cancer Cells ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells
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