scholarly journals Immunohistochemical expression and clinicopathological assessment of the cancer testis antigens NY‑ESO‑1 and MAGE‑A4 in high‑grade soft‑tissue sarcoma

2019 ◽  
Author(s):  
Takuya Kakimoto ◽  
Akihiko Matsumine ◽  
Shinichi Kageyama ◽  
Kunihiro Asanuma ◽  
Takao Matsubara ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
High Grade ◽  
Immunohistochemical Expression ◽  
Cancer Testis Antigens ◽  
Cancer Testis

scholarly journals Cancer/testis antigens expression during cultivation of melanoma and soft tissue sarcoma cells

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Anna Danilova ◽  
Vsevolod Misyurin ◽  
Aleksei Novik ◽  
Dmitry Girdyuk ◽  
Natalia Avdonkina ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Cancer Testis Antigens ◽  
Sarcoma Cells ◽  
Cancer Testis

scholarly journals Autologous dendritic-cell vaccine based on cancer-testis antigens “CaTeVac” in the treatment of soft tissue sarcoma

2018 ◽  
Vol 29 ◽  
pp. viii410-viii411 ◽  
Author(s):  
N. Pipia ◽  
I.A. Baldueva ◽  
T.L. Nekhaeva ◽  
A.V. Novik ◽  
A.B. Danilova ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Dendritic Cell Vaccine ◽  
Cell Vaccine ◽  
Autologous Dendritic Cell ◽  
Cancer Testis Antigens ◽  
Cancer Testis

scholarly journals Immunotherapy in Soft-Tissue Sarcoma

2020 ◽  
Vol 27 (11) ◽  
pp. 17-23 ◽  
Author(s):  
O. Ayodele ◽  
A.R. Abdul Razak
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Checkpoint Inhibitors ◽  
Published Data ◽  
Cell Therapies ◽  
Cancer Testis Antigens ◽  
Fusion Products ◽  
Systemic Therapies ◽  
Cancer Testis

Soft-tissue sarcoma (sts) is a rare mesenchymal malignancy that accounts for less than 1% of all adult tumours. Despite the successful advancement of localized therapies such as surgery and radiotherapy, these tumours can, for many, recur—often with metastatic disease. In the advanced setting, the role of systemic therapies is modest and is associated with poor survival. With the discovery of immunotherapies in other tumour types such as melanoma and lung cancer, interest has been renewed in exploring immunotherapy in sts. The biology of some stss makes them ripe for immunotherapy intervention; for example, some stss might have chromosomal translocations resulting in pathognomonic fusion products that have been shown to express cancer/testis antigens. Here, we present a targeted review of the published data and ongoing clinical trials for immunotherapies in patients with sarcoma, which comprise immune checkpoint inhibitors, adoptive cell therapies, and cancer vaccines.

scholarly journals Immunotherapy in soft-tissue sarcoma

2020 ◽  
Vol 26 ◽  
Author(s):  
O. Ayodele ◽  
A. R. Abdul Razak
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Checkpoint Inhibitors ◽  
Published Data ◽  
Cell Therapies ◽  
Cancer Testis Antigens ◽  
Fusion Products ◽  
Systemic Therapies ◽  
Cancer Testis

Soft-tissue sarcoma (STS) is a rare mesenchymal malignancy that accounts for less than 1% of all adult tumours. Despite the successful advancement of localized therapies such as surgery and radiotherapy, these tumours can, for many, recur—often with metastatic disease. In the advanced setting, the role of systemic therapies is modest and is associated with poor survival. With the discovery of immunotherapies in other tumour types such as melanoma and lung cancer, interest has been renewed in exploring immunotherapy in STS. The biology of some STSs makes them ripe for immunotherapy intervention; for example, some STSs might have chromosomal translocations resulting in pathognomonic fusion products that have been shown to express cancer/testis antigens. Here, we present a targeted review of the published data and ongoing clinical trials for immunotherapies in patients with sarcoma, which comprise immune checkpoint inhibitors, adoptive cell therapies, and cancer vaccines.

Neoadjuvant Chemotherapy, Radiation, and Limited Surgery for High Grade Soft Tissue Sarcoma of the Extremity

1988 ◽  
pp. 115-122 ◽  
Author(s):  
Frederick Eilber ◽  
Armando Giuliano ◽  
James Huth ◽  
Joseph Mirra ◽  
Gerald Rosen ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Neoadjuvant Chemotherapy ◽  
Soft Tissue Sarcoma ◽  
High Grade ◽  
Limited Surgery
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