scholarly journals Knockdown of DNA/RNA‑binding protein KIN17 promotes apoptosis of triple‑negative breast cancer cells

2018 ◽  
Author(s):  
Xiang Gao ◽  
Zhenping Liu ◽  
Meifeng Zhong ◽  
Kunhe Wu ◽  
Yuzhao Zhang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Triple Negative Breast Cancer ◽  
Breast Cancer Cells ◽  
Triple Negative ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein

Long non-coding RNA LINC-PINT attenuates paclitaxel resistance in triple-negative breast cancer cells via targeting the RNA-binding protein NONO

2020 ◽  
Vol 52 (8) ◽  
pp. 801-809 ◽  
Author(s):  
Jinghua Chen ◽  
Meiqin Zhu ◽  
Liqiu Zou ◽  
Junxian Xia ◽  
Jiacheng Huang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Cell Lines ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Non Coding Rna ◽  
Long Non Coding Rna

Abstract The treatment of triple-negative breast cancer (TNBC) relies largely on chemotherapies. However, it is frequent that TNBC patients develop resistance to the chemotherapy drugs. Generation of drug-resistant cell lines facilitates the identification of drug resistance. Here, we established two paclitaxel (PTX)-resistant TNBC cancer cell lines using an intermittent and stepwise method and found that long non-coding RNA long intergenic non-protein-coding RNA p53-induced transcript (LINC-PINT) was significantly decreased in PTX-resistant cancer cells. Ectopic expression of LINC-PINT sensitized both PTX-resistant TNBC and wild-type TNBC to PTX. Moreover, RNA immunoprecipitation showed that LINC-PINT bound to RNA-binding protein NONO. Overexpression of LINC-PINT resulted in the degradation of NONO in a proteasome-dependent manner and vice versa. Knockdown of NONO with siRNA sensitized TNBC to PTX. We further analyzed the expression level of LINC-PINT and NONO in patient samples via online database and found that LINC-PINT and NONO may function antagonistically in all types of breast cancers. Taken together, our data illustrated a tumor suppressor role of LINC-PINT in sensitizing TNBC to chemotherapies via destabilizing NONO.

Abstract 3271: The RNA binding protein HuR controls angiogenesis in triple negative breast cancer

2010 ◽  
Author(s):  
Ulus Atasoy ◽  
Matthew Gubin ◽  
Bob Calaluce ◽  
Wade Davis ◽  
Joseph Magee ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein

Abstract 3084: The role of RNA-binding protein HuR in lung metastasis of triple-negative breast cancer

2011 ◽  
Author(s):  
Patsharaporn Techasintana ◽  
Matthew Michael Gubin ◽  
Joseph David Magee ◽  
Garrett MacKenzie Dahm ◽  
Ulus Atasoy
Keyword(s):  
Breast Cancer ◽  
Lung Metastasis ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein

scholarly journals Overexpression of the RNA binding protein HuR impairs tumor growth in triple negative breast cancer associated with deficient angiogenesis

Cell Cycle ◽  
2010 ◽  
Vol 9 (16) ◽  
pp. 3357-3366 ◽  
Author(s):  
Matthew M Gubin ◽  
Robert Calaluce ◽  
Justin Wade Davis ◽  
Joseph D Magee ◽  
Connie S. Strouse ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Growth ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein

The RNA‐binding protein Musashi 1 stabilizes the oncotachykinin 1 mRNA in breast cancer cells to promote cell growth

2015 ◽  
Vol 30 (1) ◽  
pp. 149-159 ◽  
Author(s):  
George R. Nahas ◽  
Raghav G. Murthy ◽  
Shyam A. Patel ◽  
Teja Ganta ◽  
Steven J. Greco ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Growth ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein
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