scholarly journals Identification of potential functional genes in papillary thyroid cancer by co‑expression network analysis

2018 ◽  
Author(s):  
Zeng‑Xin Ao ◽  
Yuan‑Cheng Chen ◽  
Jun‑Min Lu ◽  
Jie Shen ◽  
Lin‑Ping Peng ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Network Analysis ◽  
Papillary Thyroid Cancer ◽  
Functional Genes ◽  
Papillary Thyroid

scholarly journals A novel lncRNA-miRNA-mRNA network analysis identified the hub lncRNA RP11-159F24.1 in the pathogenesis of papillary thyroid cancer

2018 ◽  
Vol 7 (12) ◽  
pp. 6290-6298 ◽  
Author(s):  
Wei Jiang ◽  
Hua Zhan ◽  
Yanyan Jiao ◽  
Sha Li ◽  
Weixu Gao
Keyword(s):  
Thyroid Cancer ◽  
Network Analysis ◽  
Papillary Thyroid Cancer ◽  
Papillary Thyroid

scholarly journals Identification of pivotal lncRNAs in papillary thyroid cancer using lncRNA–mRNA–miRNA ceRNA network analysis

PeerJ ◽  
2019 ◽  
Vol 7 ◽  
pp. e7441 ◽  
Author(s):  
Weiwei Liang ◽  
Fangfang Sun
Keyword(s):  
Gene Expression ◽  
Thyroid Cancer ◽  
Network Analysis ◽  
Papillary Thyroid Cancer ◽  
Enrichment Analysis ◽  
Integrated Analysis ◽  
Pathway Enrichment Analysis ◽  
Papillary Thyroid ◽  
Cerna Network ◽  
Go Terms

Background To identify pivotal lncRNAs in papillary thyroid cancer (PTC) using lncRNA–mRNA–miRNA ceRNA network analysis. Methods We obtained gene expression profiles from the gene expression omnibus database. Cancer specific lncRNA, cancer specific miRNA and cancer specific mRNA were identified. An integrated analysis was conducted to detect potential lncRNA–miRNA–mRNA ceRNA in regulating disease transformation. The lncRNA regulated gene ontology (GO) terms and regulated pathways were performed by function analysis. Survival analysis was performed for the pivotal lncRNAs. Results A total of four lncRNAs, 15 miRNAs and 375 mRNAs are identified as the key mediators in the pathophysiological processes of PTC. GO annotation enrichment analysis showed the most relevant GO terms are signal transduction, integral component of membrane and calcium ion binding. Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis showed different changed genes mainly enriched in pathways in cancer, PI3K-Akt signaling pathway and focal adhesion. Among four lncRNAs, only SLC26A4-AS1 was significantly associated with PTC patient disease free survival. Conclusion This study has constructed lncRNA–mRNA–miRNA ceRNA networks in PTC. The study provides a set of pivotal lncRNAs for future investigation into the molecular mechanisms.

Abstract #1086: Patient Experience with Severe Low Energy Following Total Thyroidectomy for Papillary Thyroid Cancer

2017 ◽  
Vol 23 ◽  
pp. 258
Author(s):  
Elizabeth Wendt ◽  
Maria Bates ◽  
Reese Randle ◽  
Jason Orne ◽  
Cameron Macdonald ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Total Thyroidectomy ◽  
Papillary Thyroid Cancer ◽  
Patient Experience ◽  
Low Energy ◽  
Papillary Thyroid
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