scholarly journals Downregulation of trefoil factor‑3 expression in the rectum is associated with the development of ulcerative colitis‑associated cancer

2018 ◽  
Author(s):  
Satoru Kondo ◽  
Toshimitsu Araki ◽  
Yuji Toiyama ◽  
Koji Tanaka ◽  
Mikio Kawamura ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Trefoil Factor ◽  
Trefoil Factor 3

scholarly journals Serum Human Trefoil Factor 3 is a Biomarker for Mucosal Healing in Ulcerative Colitis Patients with Minimal Disease Activity

2015 ◽  
Vol 9 (7) ◽  
pp. 575-579 ◽  
Author(s):  
Saurabh Srivastava ◽  
Saurabh Kedia ◽  
Sushil Kumar ◽  
Venigalla Pratap Mouli ◽  
Rajan Dhingra ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Disease Activity ◽  
Mucosal Healing ◽  
Minimal Disease Activity ◽  
Trefoil Factor ◽  
Trefoil Factor 3 ◽  
Minimal Disease

scholarly journals Trefoil Factor 3 is Highly Predictive of Complete Mucosal Healing Independently and in Combination with C-Reactive Protein in Patients with Ulcerative Colitis

2019 ◽  
Vol 28 ◽  
pp. 169-174 ◽  
Author(s):  
Radislav Nakov ◽  
Tsvetelina Velikova ◽  
Ventsislav Nakov ◽  
Vanya Gerova ◽  
Lyudmila Tankova
Keyword(s):  
Ulcerative Colitis ◽  
Area Under The Curve ◽  
Predictive Marker ◽  
Mucosal Healing ◽  
Clinical Activity ◽  
Trefoil Factor ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Trefoil Factor 3 ◽  
Significant Difference

Aim: In the current study we aimed to evaluate the role of trefoil factor 3 (TFF3) as a marker for complete mucosal healing (MH) in patients with ulcerative colitis (UC). Methods: We enrolled 116 consecutive UC patients. Trefoil factor 3 levels were measured by ELISA and were compared to the clinical activity, assessed by Lichtiger Index, fecal calprotectin (FCP) and C-reactive protein (CRP) levels. Colonoscopy was performed in all the patients and the findings were graded according to Mayo endoscopic score (EMS) and UC endoscopic index of severity (UCEIS). Results: Trefoil factor 3 levels were significantly correlated with Lichtiger Index (r=0.736, p<0.001), EMS (r=0.811, p<0.001), UCEIS (r=0.820, p<0.001), FCP (r=0.696, p<0.001) and CRP (r=0.405, p<0.001). The TFF3 cut-off level of 6.74 ng/ml indicated complete MH (EMS=0; UCEIS=0) with a sensitivity and specificity of 0.879 and 0.869, respectively (area under the curve, AUC 0.927; 95% confidence interval, 0.877–0.976). The DeLong’s test revealed no significant difference between the AUC of TFF3+CRP and the AUC of FCP (Z=1.717, p=0.086), AUC of TFF3+FCP (Z=1.908, p=0.056), and AUC of TFF3+CRP+FCPP (Z=1.915, p=0.056). However, the AUC of TFF3+CRP showed significant difference compared with the AUC of TFF3 (Z=2.210, p=0.027) and the AUC of CRP (Z=3.145, p=0.002) for predicting complete MH. Conclusions: Trefoil factor 3 levels correlated significantly with clinical activity, endoscopic indices, CRP and FCP in our patients. TFF3 is a highly predictive marker of complete MH independently and in combination with CRP in patients with UC.

scholarly journals PI3K/Akt Signaling Pathway in the Basolateral Amygdala Mediates the Rapid Antidepressant-like Effects of Trefoil Factor 3

2012 ◽  
Vol 37 (12) ◽  
pp. 2671-2683 ◽  
Author(s):  
Hai-Shui Shi ◽  
Wei-Li Zhu ◽  
Jian-Feng Liu ◽  
Yi-Xiao Luo ◽  
Ji-Jian Si ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Basolateral Amygdala ◽  
Akt Signaling ◽  
Trefoil Factor ◽  
Akt Signaling Pathway ◽  
Trefoil Factor 3

167: Role of trefoil factor-3 peptide (TFF3) in prostate cancer progression

2014 ◽  
Vol 50 ◽  
pp. S37 ◽  
Author(s):  
M. Nowak ◽  
C. Merz ◽  
A. Von Maessenhausen ◽  
W. Vogel ◽  
D. Boehm ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Progression ◽  
Prostate Cancer Progression ◽  
Trefoil Factor ◽  
Trefoil Factor 3

S2039 The Effect of Altering Trefoil Factor-3 (TFF3) Expression On Gene Expression and Function in Human Gastrointestinal Cancer Cells

2009 ◽  
Vol 136 (5) ◽  
pp. A-318
Author(s):  
Hisayuki Matsunaga ◽  
Xiuliang Bao ◽  
Lawrence Werther ◽  
Soichiro Miura ◽  
Steven H. Itzkowitz
Keyword(s):  
Gene Expression ◽  
Cancer Cells ◽  
Gastrointestinal Cancer ◽  
Trefoil Factor ◽  
Trefoil Factor 3 ◽  
And Function

scholarly journals ERG Cooperates with Androgen Receptor in Regulating Trefoil Factor 3 in Prostate Cancer Disease Progression

Neoplasia ◽  
2010 ◽  
Vol 12 (12) ◽  
pp. 1031-IN22 ◽  
Author(s):  
David S. Rickman ◽  
Ying-bei Chen ◽  
Samprit Banerjee ◽  
Yihang Pan ◽  
Jindan Yu ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Disease Progression ◽  
Trefoil Factor ◽  
Cancer Disease ◽  
Trefoil Factor 3

Research on Function of Exosome of miR-328-3p Secreted by Bone Marrow Mesenchymal Stem Cells (BMSCs) on Restraining the Gastric Cancer Through Being Down-Regulated with Trefoil Factor 3

2022 ◽  
Vol 12 (4) ◽  
pp. 854-861
Author(s):  
Jing Li ◽  
Bo Xie ◽  
Hu Wang ◽  
Chengsong Chen ◽  
Chengwu Pan ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Bone Marrow ◽  
Cell Proliferation ◽  
Gastric Cancer Tissue ◽  
Cancer Tissue ◽  
Trefoil Factor ◽  
Trefoil Factor 3 ◽  
Marrow Mesenchymal Stem Cells ◽  
Made In ◽  
E Cadherin

Certain progress has been made in the therapeutic method against gastric cancer such as surgical operation combined with chemotherapy and radiation therapy in recent years. But the therapeutic efficacy and prognosis on gastric cancer was still not satisfactory. The function of exosome of miR-328–3p secreted by bone marrow stromal cells (BMSCs) on restraining the gastric cancer was studied in the present study. The BMSCs with highly-expressed miR-328-3p was established. The exosome in cell supernatant was collected. The exosome of BMSCs and MSCs with highlyexpressed miR-328-3p was added into SGC-7901 cells followed by analysis of miR-328-3p level by Real-time PCR and TFF3 (Trefoil Factor 3) level in exosome by Western blot, cell proliferation, expression of E-cadherin, Vimentin and Caspase-3. miR-328-39 expression was reduced and TFF3 was elevated in gastric cancer tissue (P < 0.05). miR-328-3p was upregulated and TFF3 was downregulated after addition of BMSCs exosomes along with increased cell proliferation and reduced E-cadherin and Caspase3 expression (P < 0.05). In conclusion, exosome of BMSCs could be regulated by miR-328-3p and TFF3 expression is restrained so as to regulate the biological behaviors of gastric cancer cell.

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