scholarly journals PO2‑based biodosimetry evaluation using an EPR technique acts as a sensitive index for chemotherapy

2018 ◽  
Author(s):  
Yuanjing Li ◽  
Shengxin Xu ◽  
Ming Cai
Keyword(s):  
Sensitive Index

Demonstration and Quantitation of Pharmacological Inhibition of Pulmonary Uptake of N-lsopropyl-123l-p-lodoamphetamine by Propranolol

1989 ◽  
Vol 28 (03) ◽  
pp. 100-104 ◽  
Author(s):  
S. F. Akber
Keyword(s):  
Binding Sites ◽  
Bolus Injection ◽  
Cell Function ◽  
Lung Pathology ◽  
Lung Uptake ◽  
Pharmacological Inhibition ◽  
Sensitive Index ◽  
Pulmonary Uptake ◽  
First Pass

The first-pass pulmonary extraction values of N-lsopropyl-123l-p-lodoamphetamine (123I-IMP) in pretreated dogs decreases from 90 to 62% as the amount of propranolol increases from 0 to 20 mg. The first-pass pulmonary extraction values of 123I-IMP in dogs with a simultaneous bolus injection of propranolol decreases from 90 to 62% as the amount of propranolol increases from 0 to 10 mg. The pulmonary extraction of 123I-IMP with a simultaneous bolus injection of ketamine and 123I-IMP decreases from 90 to 64% as the ketamine dose increases from 0 to 100 mg. These results suggest that the pulmonary uptake of 123I-IMP may be at least partially mediated by receptors. They also indicate that endothelial metabolic cell function may be a useful index of early lung pathology. Furthermore, studies of the degree of lung uptake may be a sensitive index of pathologic states in which alterations of amine binding sites have occurred.

The two-minute walking test: a sensitive index of mobility in the rehabilitation of elderly patients

1990 ◽  
Vol 4 (4) ◽  
pp. 273-276 ◽  
Author(s):  
DA Stewart ◽  
Jma Burns ◽  
SG Dunn ◽  
MA Roberts
Keyword(s):  
Elderly Patients ◽  
Walking Test ◽  
Sensitive Index

The Sulphur Nutrition of Coconut

1977 ◽  
Vol 13 (3) ◽  
pp. 265-271 ◽  
Author(s):  
M. A. T. De Silva ◽  
Greta M. Anthonypillai ◽  
D. T. Mathes
Keyword(s):  
Response Curve ◽  
Total Yield ◽  
Sulphur Content ◽  
Initial Growth ◽  
Sulphur Nutrition ◽  
Sensitive Index ◽  
Dilution Effects

SUMMARYThe sulphur content in the sixth leaf from the apex of coconut palms was found to be the most sensitive index to sulphur treatments. Although the S concentration in this leaf correlated negatively with applied levels of S, the response curve was concave. Sulphur treatments increased the total yield of fruits and weight of copra, but decreased the weight of kernel per nut. The derived curve for yield versus S concentration in the tissue was C-shaped, attributed to growth dilution effects caused by enhanced initial growth following the restoration of a nutrient in minimum.

Aerosol penetrance: a sensitive index of peripheral airways obstruction

1976 ◽  
Vol 40 (3) ◽  
pp. 468-471 ◽  
Author(s):  
M. B. Dolovich ◽  
J. Sanchis ◽  
C. Rossman ◽  
M. T. Newhouse
Keyword(s):  
Chronic Obstructive Lung Disease ◽  
Outer Zone ◽  
Normal Subjects ◽  
Airway Disease ◽  
Chronic Obstructive ◽  
Closing Volume ◽  
Small Airways ◽  
Peripheral Airways ◽  
Sensitive Index ◽  
Airways Obstruction

Early injury of the small airways has been demonstrated in asymptomatic smokers. Ventilatory tests including the maximum midexpiratory flow rate and closing volume have been useful in clinical detection of small airways disease in symptomatic subjects. In the present study, airway “obstruction” was assessed aerodynamically by gamma camera measurements of chest radioactivity following the inhalation of 131I-labeled aerosol (aerodynamic mass median diameter 3 mum). Studies were performed in normal subjects, asymptomatic smokers, and patients with chronic obstructive lung disease. An aerosol penetrance index (AeP) was devised from determinations which involved 1) an analysis of central (inner zone) and peripheral (outer zone) deposition of aerosol in the lung and 2) a ratio of initial counts to 24-h counts in the periphery (outer zone) of the lung. AeP values were 41.5 +/- 11.5 for the normal group, 20.9 +/- 7.6 for the smoker group, and 10.6 +/- 5.2 for the subjects with chronic obstructive airway disease. AeP was significantly reduced in the smokers indicating that the AeP is a sensitive index of early peripheral airways obstruction.

Allergen-induced hyperresponsiveness to bradykinin is more pronounced than that to methacholine

1995 ◽  
Vol 78 (5) ◽  
pp. 1844-1852 ◽  
Author(s):  
A. R. Berman ◽  
A. G. Togias ◽  
G. Skloot ◽  
D. Proud
Keyword(s):  
Smooth Muscle ◽  
Vascular Permeability ◽  
Nerve Stimulation ◽  
Time Course ◽  
Sensory Nerve ◽  
Asthmatic Patients ◽  
Sensitive Index ◽  
Allergen Provocation ◽  
Allergen Inhalation ◽  
Induced Changes

Bradykinin reduces airflow in asthmatic patients via indirect mechanism(s), possibly involving sensory nerve stimulation and increased vascular permeability. We hypothesized that allergen inhalation, which affects reactivity of nerves and vessels, would differentially alter reactivity to bradykinin and the smooth muscle spasmogen methacholine. We compared reactivity to methacholine and bradykinin 1, 2, 4, 7, 11, and 14 days after allergen provocation in 12 atopic asthmatic patients with stable baseline reactivity to bradykinin. Maximal allergen-induced shifts from baseline in reactivity were 0.73 +/- 0.12 log unit for bradykinin compared with 0.27 +/- 0.13 log units for methacholine (P = 0.0005). Nine subjects showed significant increases in bradykinin reactivity, with four subjects increasing reactivity by > 1 log unit. Moreover, the maximal mean change in bradykinin reactivity occurred 2 days postallergen. Thus, allergen-induced changes in reactivity to bradykinin and methacholine differ in magnitude and time course. Bradykinin inhalational challenge provides a sensitive index of the airway's response to allergen.

Streaming potentials: A sensitive index of enzymatic degradation in articular cartilage

1987 ◽  
Vol 5 (4) ◽  
pp. 497-508 ◽  
Author(s):  
Eliot H. Frank ◽  
Alan J. Grodzinsky ◽  
Thomas J. Koob ◽  
David R. Eyre
Keyword(s):  
Articular Cartilage ◽  
Enzymatic Degradation ◽  
Streaming Potentials ◽  
Sensitive Index

scholarly journals The cardiac torsion as a sensitive index of heart pathology: A model study

2016 ◽  
Vol 55 ◽  
pp. 104-119 ◽  
Author(s):  
E. Cutrì ◽  
M. Serrani ◽  
P. Bagnoli ◽  
R. Fumero ◽  
M.L. Costantino
Keyword(s):  
Sensitive Index ◽  
Model Study ◽  
Heart Pathology
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