scholarly journals A meta‑analysis of transcriptome datasets characterizes malignant transformation from melanocytes and nevi to melanoma

2018 ◽  
Author(s):  
Daniel Ortega‑Bernal ◽  
Claudia Gonz�lez‑De La Rosa ◽  
Elena Arechaga‑Ocampo ◽  
Miguel Alvarez‑Avitia ◽  
Nora Moreno ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Meta Analysis

Malignant transformation of oral proliferative verrucous leukoplakia: A systematic review and meta‐analysis

Oral Diseases ◽  
2021 ◽  
Author(s):  
Pablo Ramos‐García ◽  
Miguel Ángel González‐Moles ◽  
Fernanda Weber Mello ◽  
Jose V. Bagan ◽  
Saman Warnakulasuriya
Keyword(s):  
Systematic Review ◽  
Malignant Transformation ◽  
Meta Analysis ◽  
Proliferative Verrucous Leukoplakia

scholarly journals Malignant Transformation Rate in Patients Presenting Oral Epithelial Dysplasia: Systematic Review and Meta-Analysis

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Jaffer A. Shariff ◽  
Athanasios I. Zavras
Keyword(s):  
Systematic Review ◽  
Malignant Transformation ◽  
Observational Studies ◽  
Meta Analysis ◽  
Epithelial Dysplasia ◽  
High Rate ◽  
Transformation Rate ◽  
Oral Epithelial Dysplasia ◽  
Observational Cohort ◽  
Oral Epithelial

Objective. To perform a systematic review and meta-analysis on studies that assess malignant transformation rates (MTR) of oral epithelial dysplasia. Materials and Methods. This review was planned and conducted in accordance with the meta-analysis of observational studies in epidemiology (MOOSE) guidelines. PubMed, EMBASE, Google Scholar, and Cochrane databases were screened to identify observational studies. Quality assessments were completed by two reviewers independently using the Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies. Pooled-malignant transformation rate (MTR) in person years, subgroup, sensitivity, and publication bias analysis were calculated using STATA 13.0 and Comprehensive Meta-Analysis software. Results. Sixteen observational cohort studies were identified with a total of 3708 participants from Asia, North America, and Europe. Analysis showed a MTR of 10.5% (pooled-MTR: 10.5, 95% CI: 3.7 to 17.3; fixed effect model, I2=0.0%; Q-value = 2.389; p>0.05) among patients with histologically confirmed oral epithelia dysplasia undergoing long-term follow-up. Higher MTR in person year were seen among the sever dysplastic cases (pooled-MTR: 14.4%, 95% CI: 5.3% to 23.5%), studies published in Europe (pooled-MTR: 12.6%, 95% CI: 8.0% to 24.3%), and retrospective studies (pooled-MTR: 11.0%, 95% CI: 2.2% to 19.9%). Conclusion. These studies show that oral epithelial dysplasia has a significant high rate of transformation to cancer.

scholarly journals Squamous Cell Carcinoma of the Scalp Masquerading as Trichilemmal Tumor of the Scalp

2014 ◽  
Vol 5 (3) ◽  
pp. 144-147
Author(s):  
Sudhir Naik ◽  
Rajshekar Halkud ◽  
A Nanjundappa ◽  
Siddharth Biswas ◽  
M Samskruthi ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Malignant Transformation ◽  
Squamous Cell ◽  
Meta Analysis ◽  
External Beam Radiotherapy ◽  
Management Protocol ◽  
Proliferating Trichilemmal Tumor ◽  
Enhanced Computed Tomography ◽  
Split Skin

ABSTRACT Background Adnexal components tumors of the skin are very rare and are seen as benign lesions of the scalp in aged women. Trichilemmal tumor is usually benign and rarely under-goes malignant transformation in a stepwise manner starting with an adenomatous stage of the trichilemmal cyst to an epitheliomatous stage of the proliferating trichilemmal tumor (PTT) evolving into the carcinomatous stage of the malignant proliferating trichilemmal tumor (MPTT). Case report A 53-year-old woman reported with huge swelling in the posterior region of the scalp. The swelling was mobile and soft to firm in consistency not fixed to the skull bone. The surface was smooth and getting under the swelling was not possible, needle biopsy reported as trichilemmal tumor. Contrast enhanced computed tomography (CECT) neck did not show any nodes in the neck, especially the posterior compartment. The tumor was widely excised with 1 cm margin and the periosteum was kept intact with split skin graft. An area of periosteal adher ence to the tumor seen was excised. The histopathology report on serial sectioning reported grade 1 moderately differentiated squamous cell carcinoma (SCC). Postoperative external beam radiotherapy of 66 Gy was given. The patient is being followed up and no recurrence is seen. Conclusion Malignant transformation in a proliferating trichilemmal tumor a rare entity and should be differentiated from SCC and the better prognostic trichilemmal carcinoma. A protocolbased adjuvant therapy is available for squamous cell carcinoma but not for trichilemmal carcinoma (TLC) and MPTT. A major meta-analysis may help to establish a clinical outcome-based classification and management protocol for these tumors. How to cite this article Nanjundappa A, Halkud R, Venugopal B, Chavan P, Sidappa KT, Biswas S, Samskruthi M, Naik SM. Squamous Cell Carcinoma of the Scalp Masquerading as Trichi-lemmal Tumor of the Scalp. Int J Head Neck Surg 2014;5(3):144-147.

Laser excision of oral leukoplakia: Does it affect recurrence and malignant transformation? A systematic review and meta-analysis

Oral Oncology ◽  
2020 ◽  
Vol 109 ◽  
pp. 104850
Author(s):  
Mariana de Pauli Paglioni ◽  
Cesar Augusto Migliorati ◽  
Isabel Schausltz Pereira Faustino ◽  
Bruno Augusto Linhares Almeida Mariz ◽  
Ana Luiza Oliveira Corrêa Roza ◽  
...  
Keyword(s):  
Systematic Review ◽  
Malignant Transformation ◽  
Meta Analysis ◽  
Oral Leukoplakia ◽  
Laser Excision

Predictive value of CCND1 /cyclin D1 alterations in the malignant transformation of potentially malignant head and neck disorders: Systematic review and meta‐analysis

Head & Neck ◽  
2019 ◽  
Vol 41 (9) ◽  
pp. 3395-3407 ◽  
Author(s):  
Pablo Ramos‐García ◽  
Miguel Ángel González‐Moles ◽  
Ángela Ayén ◽  
Lucía González‐Ruiz ◽  
José Antonio Gil‐Montoya ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cyclin D1 ◽  
Head And Neck ◽  
Malignant Transformation ◽  
Predictive Value ◽  
Meta Analysis ◽  
Potentially Malignant ◽  
Neck Disorders

Malignant transformation risk of oral lichen planus: A systematic review and comprehensive meta-analysis

Oral Oncology ◽  
2019 ◽  
Vol 96 ◽  
pp. 121-130 ◽  
Author(s):  
Miguel Ángel González-Moles ◽  
Isabel Ruiz-Ávila ◽  
Lucía González-Ruiz ◽  
Ángela Ayén ◽  
José Antonio Gil-Montoya ◽  
...  
Keyword(s):  
Systematic Review ◽  
Malignant Transformation ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Meta Analysis ◽  
Oral Lichen
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