scholarly journals Elevated FUS/TLS expression is negatively associated with E‑cadherin expression and prognosis of patients with non‑small cell lung cancer

2018 ◽  
Author(s):  
Dian Xiong ◽  
Yong‑Bing Wu ◽  
Chun Jin ◽  
Ji‑Jun Li ◽  
Jie Gu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Negatively Associated ◽  
E Cadherin

scholarly journals Broad-Spectrum Antibiotic Regimen Affects Survival in Patients Receiving Nivolumab for Non-Small Cell Lung Cancer

2021 ◽  
Vol 14 (5) ◽  
pp. 445
Author(s):  
Min Jung Geum ◽  
Chungsoo Kim ◽  
Ji Eun Kang ◽  
Jae Hee Choi ◽  
Jae Song Kim ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Broad Spectrum ◽  
Small Cell ◽  
Defined Daily Dose ◽  
Small Cell Lung ◽  
Broad Spectrum Antibiotic ◽  
Negatively Associated ◽  
Daily Dose

Antibiotic-induced dysbiosis may affect the efficacy of immune checkpoint inhibitors. We investigated the impact of antibiotics on the clinical outcomes of nivolumab in patients with non-small cell lung cancer (NSCLC). Patients who received nivolumab for NSCLC between July 2015 and June 2018 and who were followed up until June 2020 were included in a retrospective cohort analysis. Of 140 eligible patients, 70 were on antibiotics. Overall survival (OS) was shorter in patients on antibiotics (ABX) compared to those not on antibiotics (NoABX) (p = 0.014). OS was negatively associated with piperacillin/tazobactam (PTZ) (HR = 3.31, 95% CI: 1.77–6.18), days of therapy (DOT) ≥ 2 weeks (HR = 2.56, 95% CI: 1.30–5.22) and DOT of PTZ. The defined daily dose (DDD) in PTZ (r = 0.27) and glycopeptides (r = 0.21) showed weak correlations with mortality. There was no difference in progression-free survival (PFS) between ABX and NoABX; however, PFS was negatively associated with the antibiotic class PTZ and DOT of PTZ. Therefore, the use of a broad-spectrum antibiotic, such as PTZ, the long-term use of antibiotics more than 2 weeks in total and the large amount of defined daily dose of specific antibiotics were associated with decreased survival in patients receiving nivolumab for NSCLC.

scholarly journals Cetuximab Attenuates Metastasis and u-PAR Expression in Non–Small Cell Lung Cancer: u-PAR and E-Cadherin are Novel Biomarkers of Cetuximab Sensitivity

2009 ◽  
Vol 69 (6) ◽  
pp. 2461-2470 ◽  
Author(s):  
Dessislava A. Nikolova ◽  
Irfan A. Asangani ◽  
Laura D. Nelson ◽  
Dennis P.M. Hughes ◽  
Doris R. Siwak ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Novel Biomarkers ◽  
E Cadherin

scholarly journals Notch1 destabilizes the adherens junction complex through upregulation of the Snail family of E-cadherin repressors in non-small cell lung cancer

2013 ◽  
Vol 30 (3) ◽  
pp. 1423-1429 ◽  
Author(s):  
ARUM KIM ◽  
EUN YOUNG KIM ◽  
EUN NA CHO ◽  
HYUNG JUNG KIM ◽  
SE KYU KIM ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Adherens Junction ◽  
Small Cell ◽  
Small Cell Lung ◽  
Snail Family ◽  
E Cadherin

scholarly journals E-cadherin negatively regulates neoplastic growth in non-small cell lung cancer: role of Rho GTPases

Oncogene ◽  
2010 ◽  
Vol 29 (19) ◽  
pp. 2760-2771 ◽  
Author(s):  
L Asnaghi ◽  
W C Vass ◽  
R Quadri ◽  
P M Day ◽  
X Qian ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Rho Gtpases ◽  
Small Cell ◽  
Small Cell Lung ◽  
Neoplastic Growth ◽  
E Cadherin

scholarly journals Alex3 suppresses non–small cell lung cancer invasion via AKT/Slug/E-cadherin pathway

Tumor Biology ◽  
2017 ◽  
Vol 39 (7) ◽  
pp. 101042831770144 ◽  
Author(s):  
Jiang Du ◽  
Xiupeng Zhang ◽  
Haijing Zhou ◽  
Yuan Miao ◽  
Yong Han ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Cancer Invasion ◽  
Small Cell ◽  
Small Cell Lung ◽  
E Cadherin

Reduced E-Cadherin Expression Is Associated with Increased Lymph Node Metastasis and Unfavorable Prognosis in Non-small Cell Lung Cancer

1998 ◽  
Vol 157 (4) ◽  
pp. 1319-1323 ◽  
Author(s):  
MAARTEN A. SULZER ◽  
MATHIE P. G. LEERS ◽  
JAN A. van NOORD ◽  
EWALD C. M. BOLLEN ◽  
PAUL H. M. H. THEUNISSEN
Keyword(s):  
Lung Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Node Metastasis ◽  
E Cadherin
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