scholarly journals Activation of the TLR4/MyD88 signaling pathway contributes to the development of human hepatocellular carcinoma via upregulation of IL‑23 and IL‑17A

2018 ◽  
Author(s):  
Yuming Kang ◽  
Guoai Su ◽  
Jianmin Sun ◽  
Yanli Zhang
Keyword(s):  
Hepatocellular Carcinoma ◽  
Signaling Pathway ◽  
Human Hepatocellular Carcinoma ◽  
Myd88 Signaling

scholarly journals Physagulide Q suppresses proliferation and induces apoptosis in human hepatocellular carcinoma cells by regulating the ROS-JAK2/Src-STAT3 signaling pathway

RSC Advances ◽  
2017 ◽  
Vol 7 (21) ◽  
pp. 12793-12804 ◽  
Author(s):  
Yan-Wei Yang ◽  
Lei Yang ◽  
Chao Zhang ◽  
Cai-Yun Gao ◽  
Ting Ma ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Signaling Pathway ◽  
Natural Compound ◽  
Carcinoma Cells ◽  
Human Hepatocellular Carcinoma ◽  
Hepatocellular Carcinoma Cells ◽  
Stat3 Signaling ◽  
Stat3 Signaling Pathway ◽  
Physalis Angulata ◽  
Human Hepatocellular Carcinoma Cells

Physagulide Q (PQ), a new natural compound, was isolated from Physalis angulata L. in our laboratory.

Cyclosporin A activates human hepatocellular carcinoma (HepG2 cells) proliferation: implication of EGFR-mediated ERK1/2 signaling pathway

2020 ◽  
Vol 393 (5) ◽  
pp. 897-908 ◽  
Author(s):  
Mohammed E. Abo-El Fetoh ◽  
Gouda K. Helal ◽  
I. G. Saleh ◽  
M. Ewees ◽  
Mohamed ElShafey ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cyclosporin A ◽  
Signaling Pathway ◽  
Hepg2 Cells ◽  
Human Hepatocellular Carcinoma

Cyclovirobuxine D Exerts Anticancer Effects by Suppressing the EGFR-FAK-AKT/ERK1/2-Slug Signaling Pathway in Human Hepatocellular Carcinoma

2020 ◽  
Vol 39 (3) ◽  
pp. 355-367 ◽  
Author(s):  
Jiuwei Zhang ◽  
Yaodong Chen ◽  
Jing Lin ◽  
Ruimei Jia ◽  
Tingting An ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Signaling Pathway ◽  
Human Hepatocellular Carcinoma ◽  
Anticancer Effects

scholarly journals Induction of Apoptosis by Isoalantolactone in Human Hepatocellular Carcinoma Hep3B Cells through Activation of the ROS-Dependent JNK Signaling Pathway

Pharmaceutics ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 1627
Author(s):  
Min Yeong Kim ◽  
Hyesook Lee ◽  
Seon Yeong Ji ◽  
So Young Kim ◽  
Hyun Hwangbo ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Signaling Pathway ◽  
Human Hepatocellular Carcinoma ◽  
Multicellular Tumor Spheroid ◽  
Jnk Signaling ◽  
Anti Cancer ◽  
Jnk Signaling Pathway ◽  
Hep3b Cells ◽  
Induction Of Apoptosis ◽  
Cancer Activity

Isoalantolactone (IALT) is one of the isomeric sesquiterpene lactones isolated from the roots of Inula helenium L. IALT is known to possess various biological and pharmacological activities, but its anti-cancer mechanisms are not well understood. The aim of the present study was to investigate the anti-proliferative effects of IALT in human hepatocellular carcinoma (HCC) cells and to evaluate the potential anti-cancer mechanisms. Our results demonstrated that IALT treatment concentration-dependently suppressed the cell survival of HCC Hep3B cells, which was associated with the induction of apoptosis. IALT increased the expression of death-receptor-related proteins, activated caspases, and induced Bid truncation, subsequently leading to cleavage of poly (ADP-ribose) polymerase. In addition, IALT contributed to the cytosolic release of cytochrome c by destroying mitochondrial integrity, following an increase in the Bax/Bcl-2 expression ratio. However, IALT-mediated growth inhibition and apoptosis were significantly attenuated in the presence of a pan-caspase inhibitor, suggesting that IALT induced caspase-dependent apoptosis in Hep3B cells. Moreover, IALT activated the mitogen-activated protein kinases signaling pathway, and the anti-cancer effect of IALT was significantly diminished in the presence of a potent c-Jun N-terminal kinase (JNK) inhibitor. IALT also improved the generation of intracellular reactive oxygen species (ROS), whereas the ROS inhibitor significantly abrogated IALT-induced growth reduction, apoptosis, and JNK activation. Furthermore, ROS-dependent apoptosis was revealed as a mechanism involved in the anti-cancer activity of IALT in a 3D multicellular tumor spheroid model of Hep3B cells. Taken together, our findings indicate that IALT exhibited anti-cancer activity in HCC Hep3B cells by inducing ROS-dependent activation of the JNK signaling pathway.

scholarly journals Vicenin-2 is a novel inhibitor of STAT3 signaling pathway in human hepatocellular carcinoma

2020 ◽  
Vol 69 ◽  
pp. 103921 ◽  
Author(s):  
Gengzhen Huang ◽  
Shiqing Li ◽  
Yaodan Zhang ◽  
Xiaoqing Zhou ◽  
Wei Chen
Keyword(s):  
Hepatocellular Carcinoma ◽  
Signaling Pathway ◽  
Human Hepatocellular Carcinoma ◽  
Stat3 Signaling ◽  
Stat3 Signaling Pathway
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