scholarly journals Inhibition of DNA methyltransferase 1 by RNA interference reverses epithelial‑mesenchymal transition in highly metastatic 95D lung cancer cells by inhibiting the Wnt signaling pathway

2018 ◽  
Author(s):  
Xiancong Bu ◽  
Xiangyan Zhang ◽  
Jinhong Xu ◽  
Heping Yang ◽  
Xiangdong Zhou ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Rna Interference ◽  
Wnt Signaling ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Dna Methyltransferase ◽  
Epithelial Mesenchymal Transition ◽  
Wnt Signaling Pathway ◽  
Dna Methyltransferase 1 ◽  
Mesenchymal Transition

Diallyl disulphide suppresses the cannonical Wnt signaling pathway and reverses the fibronectin-induced epithelial mesenchymal transition of A549 lung cancer cells

2019 ◽  
Vol 10 (1) ◽  
pp. 191-202 ◽  
Author(s):  
Bornita Das ◽  
Dona Sinha
Keyword(s):  
Lung Cancer ◽  
Wnt Signaling ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Epithelial Mesenchymal Transition ◽  
Wnt Signaling Pathway ◽  
Lung Cancer Cells ◽  
Mesenchymal Transition ◽  
A549 Lung

DADS reflected the potential of reversal of FN-induced EMT by inhibition of Wnt signaling in A549 lung cancer cells.

scholarly journals The Role of Carcinogenesis-Related Biomarkers in the Wnt Pathway and Their Effects on Epithelial–Mesenchymal Transition (EMT) in Oral Squamous Cell Carcinoma

Cancers ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 555 ◽  
Author(s):  
Yunpeng Bai ◽  
Jingjing Sha ◽  
Takahiro Kanno
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Wnt Signaling ◽  
Tumor Progression ◽  
Cell Carcinoma ◽  
Signaling Pathway ◽  
Wnt Pathway ◽  
Epithelial Mesenchymal Transition ◽  
Wnt Signaling Pathway ◽  
Mesenchymal Transition

As oral squamous cell carcinoma (OSCC) can develop from potentially malignant disorders (PMDs), it is critical to develop methods for early detection to improve the prognosis of patients. Epithelial–mesenchymal transition (EMT) plays an important role during tumor progression and metastasis. The Wnt signaling pathway is an intercellular pathway in animals that also plays a fundamental role in cell proliferation and regeneration, and in the function of many cell or tissue types. Specific components of master regulators such as epithelial cadherin (E-cadherin), Vimentin, adenomatous polyposis coli (APC), Snail, and neural cadherin (N-cadherin), which are known to control the EMT process, have also been implicated in the Wnt cascade. Here, we review recent findings on the Wnt signaling pathway and the expression mechanism. These regulators are known to play roles in EMT and tumor progression, especially in OSCC. Characterizing the mechanisms through which both EMT and the Wnt pathway play a role in these cellular pathways could increase our understanding of the tumor genesis process and may allow for the development of improved therapeutics for OSCC.

scholarly journals miR-544ainduces epithelial–mesenchymal transition through the activation of WNT signaling pathway in gastric cancer

2015 ◽  
Vol 36 (11) ◽  
pp. 1363-1371 ◽  
Author(s):  
Yoshimitsu Yanaka ◽  
Tomoki Muramatsu ◽  
Hiroyuki Uetake ◽  
Ken-ichi Kozaki ◽  
Johji Inazawa
Keyword(s):  
Gastric Cancer ◽  
Wnt Signaling ◽  
Signaling Pathway ◽  
Epithelial Mesenchymal Transition ◽  
Wnt Signaling Pathway ◽  
Mesenchymal Transition
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