scholarly journals Long non‑coding RNA AFAP1‑antisense RNA 1 promotes the proliferation, migration and invasion of gastric cancer cells and is associated with poor patient survival

2018 ◽  
Author(s):  
Huazhou Zhao ◽  
Kecheng Zhang ◽  
Ting Wang ◽  
Jianxin Cui ◽  
Hongqing Xi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Antisense Rna ◽  
Patient Survival ◽  
Migration And Invasion ◽  
Gastric Cancer Cells ◽  
Poor Patient ◽  
Non Coding Rna ◽  
Long Non Coding Rna ◽  
Poor Patient Survival

Long non-coding RNA LINC00982 up-regulates CTSF expression to inhibit gastric cancer progression via the transcription factor HEY1

2020 ◽  
Author(s):  
Lei Zheng ◽  
Junli Cao ◽  
Lijie Liu ◽  
Hongmei Xu ◽  
Lanlan Chen ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Transcription Factor ◽  
Cancer Cells ◽  
Molecular Mechanisms ◽  
Luciferase Assay ◽  
Migration And Invasion ◽  
Gastric Cancer Cells ◽  
Non Coding Rna ◽  
Cancer Tissues ◽  
Long Non Coding Rna

Upregulating the expression of long non-coding RNA LINC00982 controlled cell proliferation in gastric cancer, but the regulatory molecular mechanisms are yet to be expounded. We here aimed to elaborate how LINC00982 regulated the malignancy of gastric cancer cells. RT-qPCR and Western blot analysis were used to detect the expression of LINC00982 and CTSF in gastric cancer tissues and cells. Modulatory effect of LINC00982 on gastric cancer cells was assessed by CCK-8, colony formation, Transwell migration and invasion assays. The relationship between LINC00982, HEY1 and CTSF was examined by RIP, luciferase assay, and ChIP, and their interaction in the regulation of gastric cancer cellular functions was analyzed by performing gain-of-function and rescue assays. The nude mouse model of tumor formation was developed to examine the effects of LINC00982 on tumorigenesis. LINC00982 was lowly expressed in gastric cancer tissues, while its overexpression impaired the proliferative, migratory and invasive properties of gastric cancer cells. Furthermore, LINC00982 could bind to transcription factor HEY1 and inhibited its expression. Through blocking the binding of HEY1 to CTSF promoter. LINC00982 promoted the expression of CTSF. Overexpression of HEY1 or inhibition of CTSF could reverse the anti-tumor effects of LINC00982 on gastric cancer, which were further demonstrated in vivo. Taken together, LINC00982 acted as a tumor suppressor in gastric cancer, which is therefore suggested to be a potential anti-tumor target for gastric cancer.

scholarly journals Up-regulated long non-coding RNA H19 contributes to proliferation of gastric cancer cells

FEBS Journal ◽  
2012 ◽  
Vol 279 (17) ◽  
pp. 3159-3165 ◽  
Author(s):  
Feng Yang ◽  
Jianwei Bi ◽  
Xuchao Xue ◽  
Luming Zheng ◽  
Kangkang Zhi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Gastric Cancer Cells ◽  
Non Coding Rna ◽  
Long Non Coding Rna

Long non-coding RNA NEAT1 decreases the chemosensitivity of gastric cancer cells via regulating P-glycoprotein expression

2017 ◽  
Vol 13 (3) ◽  
pp. 317-325 ◽  
Author(s):  
Jian Wang ◽  
Qiong Niu ◽  
Ning Shi ◽  
Chengxia Liu ◽  
Haifeng Lian ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Gastric Cancer Cells ◽  
P Glycoprotein ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals Long Non-Coding RNA HAND2-AS1 Inhibits Growth and Migration of Gastric Cancer Cells Through Regulating the miR-590-3p/KCNT2 Axis [Retraction]

2021 ◽  
Vol Volume 14 ◽  
pp. 4997-4998
Author(s):  
Lan Yu ◽  
Hui Li ◽  
Zhiying Li ◽  
Jianchao Jia ◽  
Zhouying Wu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Gastric Cancer Cells ◽  
Non Coding Rna ◽  
And Migration ◽  
Long Non Coding Rna
Sign in / Sign up

Export Citation Format

Share Document