scholarly journals Monopolar spindle-one-binder protein 2 regulates the activity of large tumor suppressor/yes-associated protein to inhibit the motility of SMMC-7721 hepatocellular carcinoma cells

2018 ◽  
Author(s):  
Weicheng Zhang ◽  
Jingyuan Shen ◽  
Fengming Gu ◽  
Ying Zhang ◽  
Wenjuan Wu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Tumor Suppressor ◽  
Carcinoma Cells ◽  
Large Tumor ◽  
Hepatocellular Carcinoma Cells ◽  
Monopolar Spindle ◽  
Large Tumor Suppressor

Abstract 3125: miR-9-3p plays a tumor-suppressor role by targeting TAZ (WWTR1) in hepatocellular carcinoma cells

2015 ◽  
Author(s):  
Takaaki Higashi ◽  
Hiromitsu Hayashi ◽  
Hideaki Takeyama ◽  
Takayoshi Kaida ◽  
Kota Arima ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Tumor Suppressor ◽  
Carcinoma Cells ◽  
Hepatocellular Carcinoma Cells

scholarly journals miR-650 Promotes the Metastasis and Epithelial–Mesenchymal Transition of Hepatocellular Carcinoma by Directly Inhibiting LATS2 Expression

2018 ◽  
Vol 51 (3) ◽  
pp. 1179-1192 ◽  
Author(s):  
Li Li Han ◽  
Xiao Ran Yin ◽  
Shu Qun Zhang
Keyword(s):  
Hepatocellular Carcinoma ◽  
Tumor Suppressor ◽  
Epithelial Mesenchymal Transition ◽  
Luciferase Assay ◽  
Large Tumor ◽  
Mesenchymal Transition ◽  
Expression Levels ◽  
Direct Target ◽  
Large Tumor Suppressor ◽  
Hcc Cells

Background/Aims: Previous studies have confirmed that microRNAs are involved in the metastasis and epithelial–mesenchymal transition (EMT) of malignancies. In this study, we examined whether miR-650 promotes the migration, invasion, and EMT of hepatocellular carcinoma (HCC) cells by targeting the large tumor suppressor kinase 2 gene (LATS2). Methods: qRT-PCR was used to detect expression of miR-650 in HCC tissues and paired normal tissues. MTT and Transwell assay were used to observe the effect of miR-650 on proliferation, migration and invasion of HCC cells. Western blot assay and Immunohistochemistry were performed to demonstrate association between miR-650 expression level and epithelial-mesenchymal transition (EMT) related protein. Mechanistically, Reporter luciferase assay was performed to reveal whether large tumor suppressor kinase 2 (LATS2) was a direct target of miR-650 in HCC cells. Results: We observed that miR-650 levels were largely up-regulated in HCC tissues, and that the increased expression was closely associated with the adverse clinical features of HCC patients. Additionally, the expression of LATS2, which was identified as a direct target of miR-650, can counteract the effects of miR-650 in HCC. Furthermore, we demonstrated that high miR-650 expression levels and low LATS2 expression levels in tumors may indicate a poor prognosis for HCC patients. Conclusion: In conclusion, the miR-650/LATS2 pathway may serve as a novel prognostic biomarker and an attractive therapeutic target for HCC patients.

scholarly journals MicroRNA-125b Functions as a Tumor Suppressor in Hepatocellular Carcinoma Cells

2012 ◽  
Vol 13 (7) ◽  
pp. 8762-8774 ◽  
Author(s):  
Hong-Yan Jia ◽  
Yu-Xuan Wang ◽  
Wen-Ting Yan ◽  
Hui-Yu Li ◽  
Yan-Zhang Tian ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Tumor Suppressor ◽  
Carcinoma Cells ◽  
Hepatocellular Carcinoma Cells

scholarly journals MicroRNA-195 acts as a tumor suppressor by directly targeting Wnt3a in HepG2 hepatocellular carcinoma cells

2014 ◽  
Vol 10 (5) ◽  
pp. 2643-2648 ◽  
Author(s):  
YANG YANG ◽  
MENGHE LI ◽  
SU’E CHANG ◽  
LUMIN WANG ◽  
TUSHENG SONG ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Tumor Suppressor ◽  
Carcinoma Cells ◽  
Hepatocellular Carcinoma Cells
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