scholarly journals Casticin inhibits the epithelial-mesenchymal transition in ovarian carcinoma via the hedgehog signaling pathway

2018 ◽  
Author(s):  
Jing Zhang ◽  
Yinghong Cui ◽  
Shuwen Sun ◽  
Jianguo Cao ◽  
Xiaoling Fang
Keyword(s):  
Ovarian Carcinoma ◽  
Signaling Pathway ◽  
Hedgehog Signaling ◽  
Epithelial Mesenchymal Transition ◽  
Hedgehog Signaling Pathway ◽  
Mesenchymal Transition

scholarly journals Hedgehog signaling in the pathogenesis of neuro-oncology diseases

2015 ◽  
Vol 61 (3) ◽  
pp. 332-342 ◽  
Author(s):  
S.A. Cherepanov ◽  
V.P. Baklaushev ◽  
A.N. Gabashvili ◽  
I.I. Shepeleva ◽  
V.P. Chekhonin
Keyword(s):  
Signaling Pathway ◽  
Hedgehog Signaling ◽  
Epithelial Mesenchymal Transition ◽  
Current Knowledge ◽  
Hedgehog Signaling Pathway ◽  
Migration Activity ◽  
Mesenchymal Transition ◽  
Oncological Diseases ◽  
Tumor Neoangiogenesis ◽  
The Impact

The review summarizes current knowledge on the Hedgehog signaling pathway, its role in normal embryogenesis and/or initiation and progression of neuro-oncological diseases, especially of high-grade gliomas, the most malignant neuroepithelial tumors. The main proteins forming the Hedgehog signaling pathway include Shh, PTCH1, SMO, HHIP, SUFU and GLI1 isoforms. Effects of other signaling pathways on the family of transcription factors GLI and other proteins are described. The review summarizes modern data about the impact of the Hedgehog signaling pathway on proliferation, migration activity and invasiveness, and also on tumor neoangiogenesis and tumor cell chemoresistance. The role of the Hedgehog signaling pathway in origin of cancer stem cells and epithelial-mesenchymal transition is also analyzed. Some prospects for new anticancer drugs acting on components of the Hedgehog signaling pathway inhibitors are demonstrated.

Sign in / Sign up

Export Citation Format

Share Document