scholarly journals A retrospective study of 34�patients with unicentric and multicentric Castleman's disease: Experience from a single institution

2017 ◽  
Author(s):  
Jin‑Peng Jiang ◽  
Xiao‑Fei Shen ◽  
Jun‑Feng Du ◽  
Wen‑Xian Guan
Keyword(s):  
Retrospective Study ◽  
Castleman’S Disease ◽  
Castleman's Disease ◽  
Single Institution ◽  
Multicentric Castleman’S Disease ◽  
Disease Experience ◽  
Multicentric Castleman's Disease

A retrospective study of unicentric and multicentric Castleman’s disease: a report of 52 patients

2009 ◽  
Vol 27 (4) ◽  
pp. 1171-1178 ◽  
Author(s):  
Bo Ye ◽  
Shu-Geng Gao ◽  
Wang Li ◽  
Long-Hai Yang ◽  
Shou-Hua Zhao ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Castleman’S Disease ◽  
Castleman's Disease ◽  
Multicentric Castleman’S Disease ◽  
Multicentric Castleman's Disease

scholarly journals Membranous nephropathy associated with multicentric Castleman’s disease that was successfully treated with tocilizumab: a case report and review of the literature

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Ryosuke Saiki ◽  
Kan Katayama ◽  
Yosuke Hirabayashi ◽  
Keiko Oda ◽  
Mika Fujimoto ◽  
...  
Keyword(s):  
Membranous Nephropathy ◽  
Periodic Acid ◽  
Castleman’S Disease ◽  
Basement Membranes ◽  
The Body ◽  
Castleman's Disease ◽  
Multicentric Castleman’S Disease ◽  
High Zinc ◽  
Secondary Membranous Nephropathy ◽  
Multicentric Castleman's Disease

Abstract Background Multicentric Castleman’s disease is a life-threatening disorder involving a systemic inflammatory response and multiple organ failure caused by the overproduction of interleukin-6. Although renal complications of Castleman’s disease include AA amyloidosis, thrombotic microangiopathy, and membranoproliferative glomerulonephritis, membranous nephropathy is relatively rare. We experienced a case of secondary membranous nephropathy associated with Castleman’s disease. Case presentation The patient was a 43-year-old Japanese man who had shown a high zinc sulfate value in turbidity test, polyclonal hypergammaglobulinemia, anemia, and proteinuria. A physical examination revealed diffuse lymphadenopathy, an enlarged spleen and papulae of the body trunk. A skin biopsy of a papule on the patient’s back showed plasma cells in the perivascular area and he was diagnosed with multicentric Castleman’s disease, plasma cell variant. Kidney biopsy showed the appearance of bubbling in the glomerular basement membranes in Periodic acid methenamine silver stain and electron microscopy revealed electron dense deposits within and outside the glomerular basement membranes. Since immunofluorescence study showed predominant granular deposition of IgG1 and IgG2, he was diagnosed with secondary membranous nephropathy associated with Castleman’s disease. He was initially treated with prednisolone alone, however his biochemical abnormalities did not improve. After intravenous tocilizumab (700 mg every 2 weeks) was started, his C-reactive protein elevation, anemia, and polyclonal gammopathy improved. Furthermore, his urinary protein level declined from 1.58 g/gCr to 0.13 g/gCr. The prednisolone dose was gradually tapered, then discontinued. He has been stable without a recurrence of proteinuria for more than 6 months. Conclusions Tocilizumab might be a treatment option for secondary membranous nephropathy associated with Castleman’s disease.

scholarly journals Human Herpesvirus-8 Infection Associated with Kaposi Sarcoma, Multicentric Castleman's Disease, and Plasmablastic Microlymphoma in a Man with AIDS: A Case Report with Review of Pathophysiologic Processes

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Christian Eaton ◽  
Russell Dorer ◽  
David M. Aboulafia
Keyword(s):  
Lymph Node ◽  
Highly Active Antiretroviral Therapy ◽  
Castleman’S Disease ◽  
Human Herpesvirus ◽  
Kaposi Sarcoma ◽  
Human Herpesvirus 8 ◽  
Castleman's Disease ◽  
Multicentric Castleman’S Disease ◽  
Herpesvirus 8 ◽  
Multicentric Castleman's Disease

Kaposi sarcoma (KS), multicentric Castleman's disease (MCD), and plasmablastic microlymphoma, are all linked to human herpesvirus-8 (HHV-8) infection and HIV-induced immunodeficiency. Herein, we describe the case of a Kenyan man diagnosed with HIV in 2000. He deferred highly active antiretroviral therapy (HAART) and remained in good health until his CD4+ count declined in 2006. He was hospitalized with bacterial pneumonia in 2008, after which he agreed to take HAART but did so sporadically. In 2010, he was hospitalized with fever, lymphadenopathy, pancytopenia, and an elevated HHV-8 viral load. A lymph node biopsy showed findings consistent with KS, MCD, and plasmablastic microlymphoma. Eight months after starting liposomal doxorubicin, Rituximab, and a new HAART regimen, he has improved clinically, and his HIV and HHV-8 viral loads are suppressed. These three conditions, found in the same lymph node, underscore the inflammatory and malignant potential of HHV-8, particularly in the milieu of HIV-induced immunodeficiency.

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