scholarly journals Phosphorylation of phosphatase and tensin homolog induced by Helicobacter pylori promotes cell invasion by activation of focal adhesion kinase

2017 ◽  
Author(s):  
Zhen Yang ◽  
Ximei Cao ◽  
Wenting Xu ◽  
Chuan Xie ◽  
Jiang Chen ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Focal Adhesion Kinase ◽  
Focal Adhesion ◽  
Cell Invasion ◽  
Phosphatase And Tensin Homolog ◽  
Tensin Homolog

Butyrate regulates the expression of c-Src and focal adhesion kinase and inhibits cell invasion of human colon cancer cells

2005 ◽  
Vol 43 (4) ◽  
pp. 207-214 ◽  
Author(s):  
Jenq-Chang Lee ◽  
Ming-Chei Maa ◽  
Hsiu-Shan Yu ◽  
Jung-Hui Wang ◽  
Chia-Kuang Yen ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Focal Adhesion Kinase ◽  
Cancer Cells ◽  
Focal Adhesion ◽  
Cell Invasion ◽  
Human Colon ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Human Colon Cancer Cells

Caveolin-1 promotes trophoblast cell invasion through the focal adhesion kinase (FAK) signalling pathway during early human placental development

2019 ◽  
Vol 31 (6) ◽  
pp. 1057 ◽  
Author(s):  
Zhihui Dai ◽  
Fei Sheng ◽  
Ningxia Sun ◽  
Yixuan Ji ◽  
Qiuying Liao ◽  
...  
Keyword(s):  
Gene Expression ◽  
Focal Adhesion Kinase ◽  
Focal Adhesion ◽  
Cell Invasion ◽  
Trophoblast Cell ◽  
Signalling Pathway ◽  
Placental Development ◽  
Human Trophoblast ◽  
Expression Levels ◽  
Caveolin 1

Normal implantation and placental development depend on the appropriate differentiation and invasion of trophoblast cells. Inadequate trophoblast cell invasion results in pregnancy-related disorders, which endanger both mother and fetus; however, the mechanism of early placental development has not been fully explained. In this study we conducted gene expression profile analysis using mouse placental tissues at different developmental stages (embryonic day (E)7.5, E14.5 and E19.5) using series tests of cluster (STC) and Kyoto Encyclopaedia of Genes and Genomes (KEGG) pathway analyses. Focal adhesion kinase (FAK) signalling pathway-related gene expression levels were verified using quantitative reverse transcription polymerase chain reaction and western blot. The results showed that caveolin-1 (Cav1) was downregulated in the placenta of unexplained spontaneous abortion subjects compared with that of induced abortion. Furthermore, by modulating CAV1 expression levels, CAV1 was shown to promote human trophoblast cell proliferation, migration and invasion by activating the FAK signalling pathway. These results indicate that CAV1 and the FAK signalling pathway are crucial for early placental development, which sheds new light on our understanding of the mechanisms of human trophoblast cell invasion and early development of the placenta.

scholarly journals Cell Invasion by Neisseria meningitidis Requires a Functional Interplay between the Focal Adhesion Kinase, Src and Cortactin

PLoS ONE ◽  
2012 ◽  
Vol 7 (6) ◽  
pp. e39613 ◽  
Author(s):  
Heiko Slanina ◽  
Sabrina Hebling ◽  
Christoph R. Hauck ◽  
Alexandra Schubert-Unkmeir
Keyword(s):  
Neisseria Meningitidis ◽  
Focal Adhesion Kinase ◽  
Focal Adhesion ◽  
Cell Invasion
Sign in / Sign up

Export Citation Format

Share Document