scholarly journals p38 MAPK‑MK2 pathway regulates the heat‑stress‑induced accumulation of reactive oxygen species that mediates apoptotic cell death in glial cells

2017 ◽  
Author(s):  
Hongbo Li ◽  
Yanan Liu ◽  
Zhengtao Gu ◽  
Li Li ◽  
Yunsong Liu ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Death ◽  
Heat Stress ◽  
P38 Mapk ◽  
Glial Cells ◽  
Apoptotic Cell ◽  
Reactive Oxygen ◽  
Apoptotic Cell Death ◽  
Oxygen Species

scholarly journals cis-Urocanic Acid Enhances Prostaglandin E2 Release and Apoptotic Cell Death via Reactive Oxygen Species in Human Keratinocytes

2011 ◽  
Vol 131 (6) ◽  
pp. 1262-1271 ◽  
Author(s):  
Kazuyo Kaneko ◽  
Susan L. Walker ◽  
Joey Lai-Cheong ◽  
Mary S. Matsui ◽  
Mary Norval ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Death ◽  
Prostaglandin E2 ◽  
Apoptotic Cell ◽  
Reactive Oxygen ◽  
Human Keratinocytes ◽  
Urocanic Acid ◽  
Apoptotic Cell Death ◽  
Oxygen Species

scholarly journals Green-Synthesized Silver Nanoparticles Induced Apoptotic Cell Death in MCF-7 Breast Cancer Cells by Generating Reactive Oxygen Species and Activating Caspase 3 and 9 Enzyme Activities

2020 ◽  
Vol 2020 ◽  
pp. 1-14
Author(s):  
Ikram Ullah ◽  
Ali Talha Khalil ◽  
Muhammad Ali ◽  
Javed Iqbal ◽  
Waqar Ali ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Silver Nanoparticles ◽  
Cell Death ◽  
Apoptotic Cell ◽  
Morphological Changes ◽  
Reactive Oxygen ◽  
Apoptotic Cell Death ◽  
Oxygen Species ◽  
Cell Viability Assay ◽  
Mcf 7

Silver nanoparticles are among the most significant diagnostic and therapeutic agents in the field of nanomedicines. In the current study, the green chemistry approach was made to optimize a cost-effective synthesis protocol for silver nanoparticles from the aqueous extract of the important anticancer plant Fagonia indica. We investigated the anticancer potential and possible involvement of AgNPs in apoptosis. The biosynthesized AgNPs are stable (zeta potential, -16.3 mV) and spherical with a crystal size range from 10 to 60 nm. The MTT cell viability assay shows concentration-dependent inhibition of the growth of Michigan Cancer Foundation-7 (MCF-7) cells (IC50, 12.35 μg/mL). In addition, the fluorescent microscopic analysis shows activation of caspases 3 and 9 by AgNPs that cause morphological changes (AO/EB assay) in the cell membrane and cause nuclear condensation (DAPI assay) that eventually lead to apoptotic cell death (Annexin V/PI assay). It was also observed that AgNPs generate reactive oxygen species (ROS) that modulate oxidative stress in MCF-7 cells. This is the first study that reports the synthesis of a silver nanoparticle mediated by Fagonia indica extract and evaluation of the cellular and molecular mechanism of apoptosis.

scholarly journals Silibinin Induced Autophagic and Apoptotic Cell Death in HT1080 Cells Through a Reactive Oxygen Species Pathway

2010 ◽  
Vol 113 (1) ◽  
pp. 48-56 ◽  
Author(s):  
Wenjun Duan ◽  
Xiaoying Jin ◽  
Qisheng Li ◽  
Shin-ichi Tashiro ◽  
Satoshi Onodera ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Death ◽  
Apoptotic Cell ◽  
Reactive Oxygen ◽  
Apoptotic Cell Death ◽  
Oxygen Species ◽  
Ht1080 Cells

scholarly journals Reactive oxygen species induced by Streptococcus pyogenes invasion trigger apoptotic cell death in infected epithelial cells

2010 ◽  
Vol 12 (6) ◽  
pp. 814-830 ◽  
Author(s):  
Chihiro Aikawa ◽  
Takashi Nozawa ◽  
Fumito Maruyama ◽  
Kohei Tsumoto ◽  
Shigeyuki Hamada ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Death ◽  
Epithelial Cells ◽  
Streptococcus Pyogenes ◽  
Apoptotic Cell ◽  
Reactive Oxygen ◽  
Apoptotic Cell Death ◽  
Oxygen Species
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