scholarly journals LIM kinase 1 serves an important role in the multidrug resistance of osteosarcoma cells

2017 ◽  
Author(s):  
Jian‑Zeng Yang ◽  
Li‑Hong Huang ◽  
Rui Chen ◽  
Ling‑Jie Meng ◽  
Yi‑Yao Gao ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Osteosarcoma Cells ◽  
Lim Kinase ◽  
Lim Kinase 1

LIM kinase-1 in the cerebral ganglion of Drosophila with genetic disturbances of kynurenine balance

2008 ◽  
Vol 418 (1) ◽  
pp. 1-3 ◽  
Author(s):  
N. G. Lopatina ◽  
T. G. Zachepilo ◽  
E. V. Savvateeva-Popova
Keyword(s):  
Cerebral Ganglion ◽  
Lim Kinase ◽  
Lim Kinase 1

scholarly journals Suppression of fibroblast cell growth by overexpression of LIM-kinase 1

FEBS Letters ◽  
1996 ◽  
Vol 396 (1) ◽  
pp. 81-86 ◽  
Author(s):  
Osamu Higuchi ◽  
Gyeong-Hun Baeg ◽  
Tetsu Akiyama ◽  
Kensaku Mizuno
Keyword(s):  
Cell Growth ◽  
Fibroblast Cell ◽  
Lim Kinase ◽  
Lim Kinase 1

scholarly journals LIM kinase 1 is required for insulin-dependent cell growth of osteosarcoma cell lines

2013 ◽  
Vol 9 (1) ◽  
pp. 103-108 ◽  
Author(s):  
HAI-SHAN ZHANG ◽  
JIAN-WU ZHAO ◽  
HONG WANG ◽  
HAN-YANG ZHANG ◽  
QIU-YE JI ◽  
...  
Keyword(s):  
Cell Growth ◽  
Cell Lines ◽  
Osteosarcoma Cell ◽  
Lim Kinase ◽  
Lim Kinase 1 ◽  
Dependent Cell ◽  
Insulin Dependent

Mechanosensitive myosin II but not cofilin primarily contributes to cyclic cell stretch-induced selective disassembly of actin stress fibers

2021 ◽  
Author(s):  
Wenjing Huang ◽  
Tsubasa S. Matsui ◽  
Takumi Saito ◽  
Masahiro Kuragano ◽  
Masayuki Takahashi ◽  
...  
Keyword(s):  
Cellular Response ◽  
Early Stage ◽  
Myosin Ii ◽  
Cyclic Stretch ◽  
Stress Fibers ◽  
Lim Kinase ◽  
Lim Kinase 1 ◽  
Chronic Activation ◽  
Selective Disassembly ◽  
Actin Stress Fibers

Cells adapt to applied cyclic stretch (CS) to circumvent chronic activation of proinflammatory signaling. Currently, the molecular mechanism of the selective disassembly of actin stress fibers (SFs) in the stretch direction, which occurs at the early stage of the cellular response to CS, remains controversial. Here we suggest that the mechanosensitive behavior of myosin II, a major cross-linker of SFs, primarily contributes to the directional disassembly of the actomyosin complex SFs in bovine vascular smooth muscle cells and human U2OS osteosarcoma cells. First, we identified that CS with a shortening phase that exceeds in speed the inherent contractile rate of individual SFs leads to the disassembly. To understand the biological basis, we investigated the effect of expressing myosin regulatory light chain mutants and found that SFs with less actomyosin activities disassemble more promptly upon CS. We consequently created a minimal mathematical model that recapitulates the salient features of the direction-selective and threshold-triggered disassembly of SFs to show that disassembly or, more specifically, unbundling of the actomyosin bundle SFs is enhanced with sufficiently fast cell shortening. We further demonstrated that similar disassembly of SFs is inducible in the presence of an active LIM-kinase-1 mutant that deactivates cofilin, suggesting that cofilin is dispensable as opposed to a previously proposed mechanism.

28 THE REGULATION OF NEURONAL OUTGROWTH AND RETRACTION BY SEROTONIN RECEPTORS 5-HT4a AND 5-HT7: THE ROLE OF LIM KINASE 1.

2006 ◽  
Vol 54 (2) ◽  
pp. S348.2-S348
Author(s):  
A. Krbanjevic ◽  
G. Liu ◽  
J. Profirovic ◽  
T. Voyno-Yasenetskaya
Keyword(s):  
Serotonin Receptors ◽  
Lim Kinase ◽  
Lim Kinase 1 ◽  
Neuronal Outgrowth

scholarly journals LIM Kinase 1 and 2 Regulate Motility and Invasion in Glioblastoma

2018 ◽  
Vol 114 (3) ◽  
pp. 652a-653a
Author(s):  
Joseph Chen ◽  
Badriprasad Ananthanarayanan ◽  
Kelsey Springer ◽  
Sanjay Kumar
Keyword(s):  
Lim Kinase ◽  
Lim Kinase 1

scholarly journals Suppression of LIM Kinase 1 and LIM Kinase 2 Limits Glioblastoma Invasion

2019 ◽  
Vol 80 (1) ◽  
pp. 69-78 ◽  
Author(s):  
Joseph Chen ◽  
Badriprasad Ananthanarayanan ◽  
Kelsey S. Springer ◽  
Kayla J. Wolf ◽  
Sharon M. Sheyman ◽  
...  
Keyword(s):  
Lim Kinase ◽  
Lim Kinase 1

scholarly journals Caspase-mediated cleavage and activation of LIM-kinase 1 and its role in apoptotic membrane blebbing

2004 ◽  
Vol 9 (6) ◽  
pp. 591-600 ◽  
Author(s):  
Go Tomiyoshi ◽  
Yuji Horita ◽  
Michiru Nishita ◽  
Kazumasa Ohashi ◽  
Kensaku Mizuno
Keyword(s):  
Lim Kinase ◽  
Membrane Blebbing ◽  
Lim Kinase 1

scholarly journals Self-association of LIM-kinase 1 mediated by the interaction between an N-terminal LIM domain and a C-terminal kinase domain

FEBS Letters ◽  
1996 ◽  
Vol 399 (1-2) ◽  
pp. 117-121 ◽  
Author(s):  
Junji Hiraoka ◽  
Ichiro Okano ◽  
Osamu Higuchi ◽  
Neng Yang ◽  
Kensaku Mizuno
Keyword(s):  
Kinase Domain ◽  
Lim Domain ◽  
Lim Kinase ◽  
Lim Kinase 1 ◽  
Self Association
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