scholarly journals Co‑expression and significance of Dok2 and Ras p21 protein activator 1 in breast cancer

2017 ◽  
Author(s):  
Jiangrong Huang ◽  
Xiaochun Peng ◽  
Kun Zhang ◽  
Chunyan Li ◽  
Bo Su ◽  
...  
Keyword(s):  
Breast Cancer ◽  
P21 Protein ◽  
Protein Activator ◽  
Ras P21

Endothelial cell activation by hemodynamic shear stress derived from arteriovenous fistula for hemodialysis access

2016 ◽  
Vol 310 (1) ◽  
pp. H49-H59 ◽  
Author(s):  
Marco Franzoni ◽  
Irene Cattaneo ◽  
Lorena Longaretti ◽  
Marina Figliuzzi ◽  
Bogdan Ene-Iordache ◽  
...  
Keyword(s):  
Shear Stress ◽  
Mrna Expression ◽  
Arteriovenous Fistula ◽  
Phospholipase D ◽  
P21 Protein ◽  
Unidirectional Flow ◽  
Protein Activator ◽  
Actin Fiber ◽  
Ras P21 ◽  
Reciprocating Flow

Intimal hyperplasia (IH) is the first cause of failure of an arteriovenous fistula (AVF). The aim of the present study was to investigate the effects on endothelial cells (ECs) of shear stress waveforms derived from AVF areas prone to develop IH. We used a cone-and-plate device to obtain real-time control of shear stress acting on EC cultures. We exposed human umbilical vein ECs for 48 h to different shear stimulations calculated in a side-to-end AVF model. Pulsatile unidirectional flow, representative of low-risk stenosis areas, induced alignment of ECs and actin fiber orientation with flow. Shear stress patterns of reciprocating flow, derived from high-risk stenosis areas, did not affect EC shape or cytoskeleton organization, which remained similar to static cultures. We also evaluated flow-induced EC expression of genes known to be involved in cytoskeletal remodeling and expression of cell adhesion molecules. Unidirectional flow induced a significant increase in Kruppel-like factor 2 mRNA expression, whereas it significantly reduced phospholipase D1, α4-integrin, and Ras p21 protein activator 1 mRNA expression. Reciprocating flow did not increase Kruppel-like factor 2 mRNA expression compared with static controls but significantly increased mRNA expression of phospholipase D1, α4-integrin, and Ras p21 protein activator 1. Reciprocating flow selectively increased monocyte chemoattractant protein-1 and IL-8 production. Furthermore, culture medium conditioned by ECs exposed to reciprocating flows selectively increased smooth muscle cell proliferation compared with unidirectional flow. Our results indicate that protective vascular effects induced in ECs by unidirectional pulsatile flow are not induced by reciprocating shear forces, suggesting a mechanism by which oscillating flow conditions may induce the development of IH in AVF and vascular access dysfunction.

scholarly journals MicroRNA-132 promotes fibroblast migration via regulating RAS p21 protein activator 1 in skin wound healing

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Xi Li ◽  
Dongqing Li ◽  
Jakob D. Wikstrom ◽  
Andor Pivarcsi ◽  
Enikö Sonkoly ◽  
...  
Keyword(s):  
Wound Healing ◽  
Skin Wound ◽  
Skin Wound Healing ◽  
P21 Protein ◽  
Fibroblast Migration ◽  
Protein Activator ◽  
Ras P21

scholarly journals RAS P21 Protein Activator 3 (RASA3) Specifically Promotes Pathogenic T Helper 17 Cell Generation by Repressing T-Helper-2-Cell-Biased Programs

Immunity ◽  
2018 ◽  
Vol 49 (5) ◽  
pp. 886-898.e5 ◽  
Author(s):  
Bing Wu ◽  
Song Zhang ◽  
Zengli Guo ◽  
Gang Wang ◽  
Ge Zhang ◽  
...  
Keyword(s):  
Cell Generation ◽  
T Helper ◽  
T Helper 17 ◽  
P21 Protein ◽  
T Helper 2 ◽  
Protein Activator ◽  
T Helper 17 Cell ◽  
Ras P21

scholarly journals Expression of ras p21, p53 and c-erbB-2 in advanced breast cancer and response to first line hormonal therapy

1995 ◽  
Vol 72 (5) ◽  
pp. 1259-1266 ◽  
Author(s):  
SG Archer ◽  
A Eliopoulos ◽  
D Spandidos ◽  
D Barnes ◽  
IO Ellis ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Advanced Breast Cancer ◽  
Hormonal Therapy ◽  
Advanced Breast ◽  
First Line ◽  
Ras P21
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