scholarly journals Impact of tumoral carbonic anhydrase IX and Ki‑67 expression on survival in oral squamous cell carcinoma patients

2017 ◽  
Author(s):  
Nigel Brockton ◽  
Pawadee Lohavanichbutr ◽  
Emeka Enwere ◽  
Melissa Upton ◽  
Elizabeth Kornaga ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Carbonic Anhydrase ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Carbonic Anhydrase Ix ◽  
Ki 67

scholarly journals The prognostic impact of a combined carbonic anhydrase IX and Ki67 signature in oral squamous cell carcinoma

2013 ◽  
Vol 109 (7) ◽  
pp. 1859-1866 ◽  
Author(s):  
A C Klimowicz ◽  
P Bose ◽  
S K Petrillo ◽  
A M Magliocco ◽  
J C Dort ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Carbonic Anhydrase ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Carbonic Anhydrase Ix ◽  
Prognostic Impact

Carbonic anhydrase IX overexpression regulates the migration and progression in oral squamous cell carcinoma

Tumor Biology ◽  
2015 ◽  
Vol 36 (12) ◽  
pp. 9517-9524 ◽  
Author(s):  
Jia-Sin Yang ◽  
Chiao-Wen Lin ◽  
Chun-Yi Chuang ◽  
Shih-Chi Su ◽  
Shu-Hui Lin ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Carbonic Anhydrase ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Carbonic Anhydrase Ix

scholarly journals Prognostic Value of Carbonic Anhydrase IX and Ki-67 Expression in Squamous Cell Carcinoma of the Tongue

2007 ◽  
Vol 37 (11) ◽  
pp. 812-819 ◽  
Author(s):  
S. J. Kim ◽  
H. J. Shin ◽  
K.-Y. Jung ◽  
S.-K. Baek ◽  
B. K. Shin ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Carbonic Anhydrase ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Prognostic Value ◽  
Carbonic Anhydrase Ix ◽  
Ki 67 ◽  
Carcinoma Of The Tongue

scholarly journals Expression of Ki-67 in normal oral epithelium, leukoplakic oral epithelium and oral squamous cell carcinoma

2014 ◽  
Vol 18 (2) ◽  
pp. 169 ◽  
Author(s):  
SmitaShrishail Birajdar ◽  
MB Radhika ◽  
K Paremala ◽  
Mohsin Gadivan ◽  
M Sudhakara ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Oral Epithelium ◽  
Ki 67

scholarly journals Evaluation of p53, Caspase-3, Bcl-2, and Ki-67 markers in oral squamous cell carcinoma and premalignant epithelium in a sample from Alava Province (Spain)

2013 ◽  
pp. e846-e850 ◽  
Author(s):  
A. Bascones-Martinez ◽  
R. Rodriguez-Gutierrez ◽  
E. Rodriguez-Gomez ◽  
JA. Gil-Montoya ◽  
R. Gomez-Font ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Caspase 3 ◽  
Ki 67

scholarly journals miR-182-5p Promotes Growth in Oral Squamous Cell Carcinoma by Inhibiting CAMK2N1

2018 ◽  
Vol 49 (4) ◽  
pp. 1329-1341 ◽  
Author(s):  
Nan Li ◽  
Chuan-Chuan Nan ◽  
Xue-Yun Zhong ◽  
Jun-Quan Weng ◽  
Hai-Dong Fan ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cell Lines ◽  
Squamous Cell ◽  
Colony Formation ◽  
Cell Counting ◽  
Control Group ◽  
Rt Pcr ◽  
Ki 67

Background/Aims: Emerging evidence suggests that the propagation of oral squamous cell carcinoma (OSCC) is influenced by the abnormal expression of microRNAs (miRNAs). This study aimed to characterize the involvement of miR-182-5p in OSCC by targeting the calcium/ calmodulin-dependent protein kinase II inhibitor CAMK2N1. Methods: miR-182-5p expression was quantified in OSCC tissues and cell lines with reverse transcription polymerase chain reaction (RT-PCR). Cell colony formation, Cell Counting Kit-8 (CCK-8), Ki-67, and nude mouse xenograft assays were used to characterize the role of miR-182-5p in the proliferation of OSCC. A miR-182-5p target gene was identified with western blotting, RT-PCR, and luciferase activity assays. OSCC patient survival based on CAMK2N1 expression was also analyzed. Results: miR-182-5p was up-regulated in in vitro cell lines and in vivo clinical OSCC samples. CCK-8, colony formation, and Ki-67 assays revealed that miR-182-5p promoted the growth and proliferation of OSCC cells. miR-182-5p directly targeted CAMK2N1, as evidenced by luciferase assays and target prediction algorithms. CAMK2N1 operated as a tumor suppressor gene in patients with OSCC. Down-regulating miR-182-5p expression in the CAL-27 cell line restored CAMK2N1-mediated OSCC cell proliferation. miR-182-5p expression inhibited the activation of AKT, ERK1/2, and NF-κB. Mice injected with CAL-27 cells transfected with miR-182-5p-inhibitor demonstrated a significant increase in tumor size and weight and increased CAMK2N1 mRNA and protein expression compared with the miR-negative control group. Conclusion: The miR-182-5p-CAMK2N1 pathway can be potentially targeted to regulate the proliferation of OSCC cells.

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