scholarly journals Specific expression of proton-coupled oligopeptide transporter 1 in primary hepatocarcinoma-a novel strategy for tumor-targeted therapy

2017 ◽  
Vol 14 (4) ◽  
pp. 4158-4166 ◽  
Author(s):  
Yanxia Gong ◽  
Jie Zhang ◽  
Xiang Wu ◽  
Tao Wang ◽  
Jia Zhao ◽  
...  
Keyword(s):  
Targeted Therapy ◽  
Oligopeptide Transporter ◽  
Specific Expression ◽  
Primary Hepatocarcinoma ◽  
Novel Strategy

scholarly journals Specific expression of PD-L1 in RELA-fusion supratentorial ependymoma: Implications for PD-1-targeted therapy

2018 ◽  
Vol 65 (5) ◽  
pp. e26960 ◽  
Author(s):  
Davis A. Witt ◽  
Andrew M. Donson ◽  
Vladimir Amani ◽  
Daniel C. Moreira ◽  
Bridget Sanford ◽  
...  
Keyword(s):  
Targeted Therapy ◽  
Specific Expression ◽  
Supratentorial Ependymoma

scholarly journals Ligand-based targeted therapy: a novel strategy for hepatocellular carcinoma

2016 ◽  
Vol Volume 11 ◽  
pp. 5645-5669 ◽  
Author(s):  
Min Li ◽  
Weiyue Zhang ◽  
Birong Wang ◽  
Yang Gao ◽  
Zifang Song ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Targeted Therapy ◽  
Novel Strategy

scholarly journals Tumor-specific expression of shVEGF and suicide gene as a novel strategy for esophageal cancer therapy

2016 ◽  
Vol 22 (23) ◽  
pp. 5342 ◽  
Author(s):  
Ting Liu ◽  
Hai-Jun Wu ◽  
Yu Liang ◽  
Xu-Jun Liang ◽  
Hui-Chao Huang ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Cancer Therapy ◽  
Suicide Gene ◽  
Specific Expression ◽  
Novel Strategy

Ultrasound-Targeted Delivery Technology: A Novel Strategy for Tumor- Targeted Therapy

2018 ◽  
Vol 20 (2) ◽  
pp. 220-231 ◽  
Author(s):  
Meng Du ◽  
Zhiyi Chen ◽  
Yuhao Chen ◽  
Yue Li
Keyword(s):  
Targeted Therapy ◽  
Targeted Delivery ◽  
Gene Transfection ◽  
Molecular Probes ◽  
Ultrasound Contrast Agents ◽  
Tumor Treatment ◽  
Gas Treatment ◽  
Novel Strategy ◽  
Targeted Release ◽  
Delivery Technology

Background: Ultrasound has been widely used in clinical diagnosis because it is noninvasive, inexpensive, simple, and reproducible. With the development of molecular imaging, material science, and ultrasound contrast agents, ultrasound-targeted delivery technology has emerged. The interaction of ultrasound and molecular probes can be exploited to change the structures of cells and tissues in order to promote the targeted release of therapeutic substances to local tumors. The targeted delivery of drugs, genes, and gases would not only improve the efficacy of tumor treatment but also avoid the systemic toxicity and side effects caused by antitumor treatments. This technology was recently applied in clinical trials and showed enormous potential for clinical application. Objective: This article briefly introduces the characteristics of the tumor microenvironment and the principle of ultrasound-targeted delivery technology. To present recent progress in this field, this review focuses on the application of ultrasound-targeted delivery technology in tumor-targeted therapy, including drug delivery, gene transfection, and gas treatment. Results: The results of this study show that ultrasound-targeted delivery technology is a promising therapeutic strategy for tumor treatment. Conclusion: Ultrasound-targeted delivery technology shows promise with regard to cancer treatment.

Targeted Therapy by Using Tissue Specific Promoter and Granules as Storage Compartments for Therapeutic Proteins in Hematopoietic Cells.

Blood ◽  
2009 ◽  
Vol 114 (22) ◽  
pp. 4508-4508
Author(s):  
Parvaneh Afsharian ◽  
Åsa Johansson ◽  
Ann-Maj Persson ◽  
Inge Olsson ◽  
Markus Hansson
Keyword(s):  
Targeted Therapy ◽  
Progenitor Cells ◽  
Conflicts Of Interest ◽  
Hematopoietic Cells ◽  
Regulatory Elements ◽  
Hematopoietic Progenitor Cells ◽  
Hematopoietic Progenitor ◽  
Specific Expression ◽  
Secretory Lysosome

Abstract Abstract 4508 Systemic administration of immunotherapeutics often give rise to severe side effects. A local deposition, using secretory lysosomes of hematopoietic cells as vehicles for delivery, may overcome this problem. Our research regarding sorting mechanisms of granule proteins have led to a new therapeutic idea – targeted therapy with hematopoietic cells as carriers. Exogenous proteins are expressed, and the gene product is directed for secretory lysosome or granule storage. These organelles are unique storage compartments in neutrophils for biological active proteins, designated for inflammatory foci. The exogenous proteins, would accordingly, be locally released at the site of inflammation. Our model construct, soluble TNF receptor 1 (sTNFR), can be directed for storage by adding a transmembranous region and a sorting signal. We have earlier shown that this construct, retrovirally expressed in murine hematopoietic progenitor cells, are destined for granule targeting. Furthermore, we have transplanted transduced murine progenitor cells with modified granule content, and found stable expression and inducible release of sTNFR1 in vivo. Our goal is cell linage specific expression in order to selectively express sTNFR1 with a transmembranous region and a signal peptide for granule targeting. To achieve this, lactoferrin, perforin and MPO promoters, including regulatory elements, have been inserted into vectors (we use a retroviral vector with self-inactivating LTRs). The vectors is retrovirally transduced into murine hematopoietic progenitor cells, and the cells are cultured during cytokine driven differentiation and analyzed by FACS and Western blotting. Our results suggest that a concept of using secretory organelles of hematopoietic cells as vehicles for therapeutic agents in vivo may become feasible. It will be possible to test this principle by experiments in animal models of inflammatory and malignant diseases. Likewise, development of this concept may give new information on secretory lysosome function and secretion at inflamed/malignant sites. Disclosures: No relevant conflicts of interest to declare.

scholarly journals A novel strategy to produce sweeter tomato fruits with high sugar contents by fruit-specific expression of a single bZIP transcription factor gene

2015 ◽  
Vol 14 (4) ◽  
pp. 1116-1126 ◽  
Author(s):  
G. H. M. Sagor ◽  
Thomas Berberich ◽  
Shun Tanaka ◽  
Manabu Nishiyama ◽  
Yoshinori Kanayama ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Bzip Transcription Factor ◽  
Transcription Factor Gene ◽  
Specific Expression ◽  
Tomato Fruits ◽  
Factor Gene ◽  
High Sugar ◽  
Novel Strategy
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