scholarly journals RAS protein activator-like 1 is functionally involved in hypoxia resistance in breast cancer cells by targeting hypoxia inducible factor-1α

2017 ◽  
Vol 14 (3) ◽  
pp. 3839-3845 ◽  
Author(s):  
Ziming Huang ◽  
Rong Wang ◽  
Gang Wei ◽  
Ran Jiang ◽  
Yuan Zheng ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Hypoxia Inducible Factor ◽  
Ras Protein ◽  
Hypoxia Inducible Factor 1Α ◽  
Protein Activator

scholarly journals Toll-Iike Receptor-3 Activation Enhances Malignant Traits in Human Breast Cancer Cells Through Hypoxia-inducible Factor-1α

2020 ◽  
Vol 40 (10) ◽  
pp. 5379-5391
Author(s):  
FRANCESCA SCATOZZA ◽  
ANTONELLA D'AMORE ◽  
ROSARIA ANNA FONTANELLA ◽  
PAOLA DE CESARIS ◽  
FRANCESCO MARAMPON ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Hypoxia Inducible Factor ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Hypoxia Inducible Factor 1Α

scholarly journals Effect of hypoxia-inducible factor-1α induction by CoCl2 on breast cancer cells survival: influence of cytochrome-c and survivin

2014 ◽  
Vol 23 (3) ◽  
pp. 139-42 ◽  
Author(s):  
Reni Paramita ◽  
Mohamad Sadikin ◽  
Noorwati Sutandyo ◽  
Septelia I. Wanandi
Keyword(s):  
Breast Cancer ◽  
Cytochrome C ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Breast Cancer Cells ◽  
Hypoxia Inducible Factor ◽  
Cancer Cell Line ◽  
Breast Cancer Cell Lines ◽  
Hypoxia Inducible Factor 1Α

Background: Tumor tissue usually became hypoxic due to disruption of oxygen supply. Adaptation response to hypoxia is mediated by transcription factor, hypoxia- inducible factor-1α (HIF-1α). HIF-1α signaling is known to increase the expression of pro-apoptotic protein cytochrome-c, and anti- apoptotic survivin. In this study we wanted to analyze the role of HIF-1α on breast cancer cells survival through pro-apoptosis cytohrome-c and anti-apoptosis survivin regulation.Methods: Breast cancer cell lines T47D were induced by CoCl2 then harvested to analyze the expression of HIF-1α, protein cytochrome-c, mRNA survivin and cell viabilities.Results: HIF-1α induction by CoCl2 causes the increase of  protein and mRNA of HIF-1α, cytochrome-c protein, and survivin mRNA, but does not cause the changes in cell viability.Conclusion: HIF-1α induction have no effects on breast cancer cell line T47D viabilities due to the balance regulation between pro-apoptosis expression cytochrome-c and anti-apoptosis survivin.

Interleukin-1β regulates the migratory potential of MDAMB231 breast cancer cells through the hypoxia-inducible factor-1α

2010 ◽  
Vol 46 (18) ◽  
pp. 3400-3408 ◽  
Author(s):  
Antonella Naldini ◽  
Irene Filippi ◽  
Diego Miglietta ◽  
Michele Moschetta ◽  
Raffaella Giavazzi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Hypoxia Inducible Factor ◽  
Interleukin 1Β ◽  
Hypoxia Inducible Factor 1Α

scholarly journals Mechanism of leptin expression in breast cancer cells: role of hypoxia-inducible factor-1α

Oncogene ◽  
2007 ◽  
Vol 27 (4) ◽  
pp. 540-547 ◽  
Author(s):  
S Cascio ◽  
V Bartella ◽  
A Auriemma ◽  
G J Johannes ◽  
A Russo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Hypoxia Inducible Factor ◽  
Hypoxia Inducible Factor 1Α ◽  
Leptin Expression
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