scholarly journals Effect of epithelial growth factor on matrix metalloproteinase-2 and E-cadherin/β-catenin expression in an in situ model of tumorigenesis

2017 ◽  
Vol 14 (3) ◽  
pp. 3136-3140
Author(s):  
Natalia Festugatto Navarini ◽  
Vera Cavalcanti De Araújo ◽  
Marcelo Sperandio ◽  
Marcelo Henrique Napimoga ◽  
Lucas Novaes Teixeira ◽  
...  
Keyword(s):  
Growth Factor ◽  
Matrix Metalloproteinase ◽  
Matrix Metalloproteinase 2 ◽  
Epithelial Growth Factor ◽  
Epithelial Growth ◽  
E Cadherin

scholarly journals E-cadherin Surface Levels in Epithelial Growth Factor-stimulated Cells Depend on Adherens Junction Protein Shrew-1

2009 ◽  
Vol 20 (15) ◽  
pp. 3598-3607 ◽  
Author(s):  
Julia Christina Gross ◽  
Alexander Schreiner ◽  
Knut Engels ◽  
Anna Starzinski-Powitz
Keyword(s):  
Growth Factor ◽  
Egf Receptor ◽  
Adherens Junction ◽  
Loss Of Function ◽  
Cell Dynamics ◽  
Epithelial Growth Factor ◽  
Adherens Junction Protein ◽  
Junction Protein ◽  
Epithelial Growth ◽  
E Cadherin

Gain- and loss-of-function studies indicate that the adherens junction protein shrew-1 acts as a novel modulator of E-cadherin internalization induced by epithelial growth factor (EGF) or E-cadherin function-blocking antibody during epithelial cell dynamics. Knocking down shrew-1 in MCF-7 carcinoma cells preserves E-cadherin surface levels upon EGF stimulation. Overexpression of shrew-1 leads to preformation of an E-cadherin/EGF receptor (EGFR) HER2/src-kinase/shrew-1 signaling complex and accelerated E-cadherin internalization. Shrew-1 is not sufficient to stimulate E-cadherin internalization, but facilitates the actions of EGFR and thus may promote malignant progression in breast cancer cells with constitutive EGFR stimulation by reducing surface E-cadherin expression.

Prostasin Impairs Epithelial Growth Factor Receptor Activation to Suppress Dengue Virus Propagation

2018 ◽  
Vol 219 (9) ◽  
pp. 1377-1388 ◽  
Author(s):  
Chun-Kuang Lin ◽  
Chin-Kai Tseng ◽  
Yu-Hsuan Wu ◽  
Chun-Yu Lin ◽  
Chung-Hao Huang ◽  
...  
Keyword(s):  
Growth Factor ◽  
Dengue Virus ◽  
Growth Factor Receptor ◽  
Receptor Activation ◽  
Epithelial Growth Factor Receptor ◽  
Virus Propagation ◽  
Epithelial Growth Factor ◽  
Epithelial Growth
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