scholarly journals Changes in telomerase activity due to alternative splicing of human telomerase reverse transcriptase in colorectal cancer

2017 ◽  
Vol 14 (2) ◽  
pp. 2385-2392 ◽  
Author(s):  
Hei Cheul Jeung ◽  
Sun Young Rha ◽  
Sang Joon Shin ◽  
Joong Bae Ahn ◽  
Kyu Hyun Park ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Alternative Splicing ◽  
Reverse Transcriptase ◽  
Telomerase Activity ◽  
Telomerase Reverse Transcriptase ◽  
Human Telomerase Reverse Transcriptase ◽  
Human Telomerase

scholarly journals Alternative Splicing of Human Telomerase Reverse Transcriptase (hTERT) and Its Implications in Physiological and Pathological Processes

Biomedicines ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 526
Author(s):  
Anna A. Plyasova ◽  
Dmitry D. Zhdanov
Keyword(s):  
Alternative Splicing ◽  
Reverse Transcriptase ◽  
Splice Variants ◽  
Biological Activities ◽  
Telomerase Activity ◽  
Telomerase Reverse Transcriptase ◽  
Human Telomerase Reverse Transcriptase ◽  
Independent Manner ◽  
A Cell ◽  
Human Telomerase

Alternative splicing (AS) of human telomerase catalytic subunit (hTERT, human telomerase reverse transcriptase) pre-mRNA strongly regulates telomerase activity. Several proteins can regulate AS in a cell type-specific manner and determine the functions of cells. In addition to being involved in telomerase activity regulation, AS provides cells with different splice variants that may have alternative biological activities. The modulation of telomerase activity through the induction of hTERT AS is involved in the development of different cancer types and embryos, and the differentiation of stem cells. Regulatory T cells may suppress the proliferation of target human and murine T and B lymphocytes and NK cells in a contact-independent manner involving activation of TERT AS. This review focuses on the mechanism of regulation of hTERT pre-mRNA AS and the involvement of splice variants in physiological and pathological processes.

scholarly journals Telomerase Activity Reconstitutedin Vitrowith Purified Human Telomerase Reverse Transcriptase and Human Telomerase RNA Component

2000 ◽  
Vol 275 (29) ◽  
pp. 22568-22573 ◽  
Author(s):  
Kenkichi Masutomi ◽  
Shuichi Kaneko ◽  
Naoyuki Hayashi ◽  
Tatsuya Yamashita ◽  
Yukihiro Shirota ◽  
...  
Keyword(s):  
Reverse Transcriptase ◽  
Telomerase Activity ◽  
Telomerase Reverse Transcriptase ◽  
Telomerase Rna ◽  
Human Telomerase Reverse Transcriptase ◽  
Human Telomerase
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