scholarly journals Analysis of gastrointestinal metastasis of primary lung cancer: Clinical characteristics and prognosis

2017 ◽  
Vol 14 (2) ◽  
pp. 2399-2404 ◽  
Author(s):  
Naohiro Taira ◽  
Tsutomu Kawabata ◽  
Atsushi Gabe ◽  
Tomonori Furugen ◽  
Takaharu Ichi ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Clinical Characteristics ◽  
Primary Lung Cancer ◽  
Gastrointestinal Metastasis

scholarly journals Clinical characteristics of synchronous multiple primary lung cancer.

1991 ◽  
Vol 38 (3) ◽  
pp. 250-254
Author(s):  
Hyuk Pyo Lee ◽  
Tae Sun Shim ◽  
Ho Jung Kim ◽  
Hyung Seok Choi ◽  
Young Whan Kim ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Clinical Characteristics ◽  
Primary Lung Cancer ◽  
Multiple Primary

Association of PIK3CA mutations and age with the occurence of second primary lung cancer (SPLC).

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. 1589-1589
Author(s):  
Marc Christiaan Allardt Bos ◽  
Masyar Gardizi ◽  
Matthias Scheffler ◽  
Lucia Nogova ◽  
Thomas Zander ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Logistic Regression Analysis ◽  
Clinical Characteristics ◽  
Pik3ca Mutation ◽  
Primary Lung Cancer ◽  
Driver Mutations ◽  
Second Primary ◽  
Pik3ca Mutations

1589 Background: The incidence of SPLC in Germany was reported to be 1.2 per 100,000 inhabitants in 2007 and the prevalence of second primary cancers reported by the US International Cancer Institute's Surveillance, Epidemiology and End Results Program has more than doubled over the last 25 years. Recently there has been tremendous progress in the ability to detect driver mutations in lung cancer and large studies presented the frequencies of driver mutations in unselected patient populations. We conducted an association study of known genetic driver events and clinical characteristics with the occurence of SPLC. Methods: Within the Network Genomic Medicine Lung Cancer, a local molecular screening network encompassing hospitals and office-based oncologists in the catchment area of the Center for Integrated Oncology Köln Bonn, we retrospectively reviewed the medical records of 375 molecularly annotated NSCLC patients for their SPLC status and clinical characteristics (age at diagnosis, histology, sex, smoking status). Molecular analysis for lung adenocarcinoma included the EGFR, ALK, BRAF, KRAS and PIK3CA status and for squamous cell lung cancer the FGFR1 and PIK3CA status. Results: 84 of 375 (22,4%) patients were SPLCs. The median age of SPLC diagnosis was 70 yrs. (Range 53 - 85 yrs.) and differed significantly from the rest of the population with a median age of 65 yrs. (Range 28 - 86 yrs.). The frequency of SPLCs was not significantly different between males and females (p = 0,259). In univariate logistic regression analysis active and former smoking, positive PIK3CA mutation and FGFR1 amplification status as well as age were significantly associated with the occurrence of SPLC. In a multivariate logistic regression analysis including the variables mentioned above only PIK3CA mutations (OR 9,48 95% CI 1,83 - 49,1) (p = 0,007) and age (OR 1,06 95% CI 1,03 - 1,1) (p = 0,015) could be confirmed to be independent prognosticators for the occurrence of SPLCs. Conclusions: The occurrence of SPLC was associated with age and PIK3CA mutations in our study population. Further comprehensive investigations on this topic are needed to confirm our findings and to further understand the association between mutation status and SPLCs.

Clinical characteristics and outcomes of simultaneous multiple primary lung cancer.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e21088-e21088
Author(s):  
Ying Liu
Keyword(s):  
Lung Cancer ◽  
Survival Rate ◽  
Clinical Features ◽  
Respiratory Symptom ◽  
Clinical Characteristics ◽  
Primary Lung Cancer ◽  
Smoking History ◽  
Multiple Primary ◽  
Worse Prognosis

e21088 Background: Simultaneous multiple primary lung cancer (sMPLC) is detected increasingly nowadays with the development of image technology. But it has not been well characterized. Methods: All consecutive patients diagnosed as sMPLC according to Martini-Melamed and American College of Chest Physicians criteria from June 2010 to June 2019 were enrolled in our center. The clinical characteristics and outcomes were compared between patients with same histology and different histology. Results: A total of 336 patients were enrolled, consist of 297 (88.4%) patients with same histology and 39(11.6%) patients with different histology. Compared to patients with same histology, patients with different histology were more common male (87.2% vs. 34%, p < 0.001) and diagnosed at an older age (54 [62-69] vs. 59 [52-65], p < 0.001). Also, more than half of them (56.4%) had respiratory symptom or pain before diagnosis and most of them had smoking history (79.5% vs. 19.2%, p < 0.001). During follow-up, 5 patients were lost and 16 patients were died, contributing the 1-, 2-, and 3-year survival of overall patients was 97.7%, 96.1%, and 92.2%, respectively. Importantly, the survival rate was lower in patients with different histology (1-, 2-, and 3-year 88.5%, 75.4, and 64.3%) than same histology (1-, 2-, and 3-year 99.2%, 99.2, and 96.8%) (p < 0.001). Conclusions: Although relative less common in sMPLC, patients with different histology showed different clinical features and worse prognosis. [Table: see text]

Clinical Characteristics and Surgery of Primary Lung Cancer in Younger Patients

2008 ◽  
Vol 16 (5) ◽  
pp. 387-391 ◽  
Author(s):  
Yasunobu Funakoshi ◽  
Shin-Ichi Takeda ◽  
Yoshihisa Kadota ◽  
Takashi Kusu ◽  
Hajime Maeda
Keyword(s):  
Lung Cancer ◽  
Cell Carcinoma ◽  
Older Patients ◽  
Clinical Characteristics ◽  
Early Stage ◽  
Survival Rates ◽  
Primary Lung Cancer ◽  
Large Cell Carcinoma ◽  
Large Cell ◽  
Younger Patients

Controversy exists regarding the clinical characteristics, pathological findings, and prognosis of patients < 50 years of age with primary lung cancer. The medical records of 4,556 patients diagnosed with primary lung cancer between 1980 and 2004 were reviewed; of these, 305 were < 50 years old. Of 1,335 patients who were surgically treated, 122 were < 50 years old. Females were over-represented in the younger group. Younger patients had a significantly higher incidence of adenocarcinoma and large cell carcinoma, and a lower incidence of squamous cell carcinoma. The resectable rate in younger patients was significantly higher. Overall and among surgically treated patients, the survival rates of younger patients with stage 0-I disease were significantly better than those of older patients. Younger patients with early-stage primary lung cancer had a significantly better prognosis than older patients, although survival in the advanced stages was not significantly different.

scholarly journals Gastrointestinal metastasis of primary lung cancer: An analysis of 366�cases

2018 ◽  
Author(s):  
Yue Hu ◽  
Noah Feit ◽  
Yanqin Huang ◽  
Wenhong Xu ◽  
Shu Zheng ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Primary Lung Cancer ◽  
Gastrointestinal Metastasis

scholarly journals Clinical characteristics and risk of second primary lung cancer after cervical cancer: A population-based study

PLoS ONE ◽  
2020 ◽  
Vol 15 (8) ◽  
pp. e0231807
Author(s):  
Chengyuan Qian ◽  
Hong Liu ◽  
Yan Feng ◽  
Shenglan Meng ◽  
Dong Wang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cervical Cancer ◽  
Clinical Characteristics ◽  
Primary Lung Cancer ◽  
Population Based ◽  
Second Primary ◽  
Population Based Study ◽  
Second Primary Lung Cancer

Gastrointestinal Metastasis From Primary Lung Cancer: CT Findings and Clinicopathologic Features

2009 ◽  
Vol 193 (3) ◽  
pp. W197-W201 ◽  
Author(s):  
So Yeon Kim ◽  
Hyun Kwon Ha ◽  
Sung Won Park ◽  
Jun Kang ◽  
Kyoung Won Kim ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Primary Lung Cancer ◽  
Clinicopathologic Features ◽  
Gastrointestinal Metastasis ◽  
Ct Findings

Survival in primary lung cancer potentially cured by operation: influence of tumor stage and clinical characteristics

2003 ◽  
Vol 75 (2) ◽  
pp. 356-363 ◽  
Author(s):  
Gunnar Myrdal ◽  
Mats Lambe ◽  
Gunnar Gustafsson ◽  
Kristina Nilsson ◽  
Elisabeth Ståhle
Keyword(s):  
Lung Cancer ◽  
Clinical Characteristics ◽  
Primary Lung Cancer ◽  
Tumor Stage

scholarly journals Differentiation of Primary Lung Cancer from Solitary Lung Metastasis in Patients with Colorectal Cancer Using Computed Tomography Features and Clinical Characteristics : A Retrospective Cohort Study

2020 ◽  
Author(s):  
Jong Eun Lee ◽  
Won Gi Jeong ◽  
Yun-Hyeon Kim
Keyword(s):  
Colorectal Cancer ◽  
Computed Tomography ◽  
Lung Cancer ◽  
Lung Metastasis ◽  
Clinical Characteristics ◽  
Wedge Resection ◽  
Clinical Stage ◽  
Primary Lung Cancer ◽  
Multivariate Logistic Regression Analysis ◽  
Ct Features

Abstract Purpose: To evaluate the features of solitary pulmonary nodule (SPN) that can be used to differentiate between primary lung cancer (LC) and solitary lung metastasis (LM) in patients with colorectal cancer (CRC).Materials and Methods: This retrospective study included SPNs resected in CRC patients between 2011 and 2019. The diagnosis of primary LC or solitary LM was based on histopathologic report by thoracoscopic wedge resection. Chest computed tomography (CT) images were assessed by two thoracic radiologists, and features were identified by consensus. Predictive parameters for the discrimination of primary LC from solitary LM were evaluated using multivariate logistic regression analysis.Results: We analyzed 199 patients (mean age, 65.95 years; 131 men). The clinical characteristics suggestive of primary LC rather than solitary LM was clinical stage I-II CRC (P < 0.001, odds ratio (OR): 21.70). The CT features of SPNs indicative of primary LC rather than solitary LM were a spiculated margin (P = 0.020, OR: 8.34), a sub-solid density (P < 0.001, OR: 115.56), and presence of an air-bronchogram (OR: 5.32; P = 0.032).Conclusions: CT features and clinical characteristics of SPNs in patients with CRC could help differentiate between primary LC and solitary LM.

Gastrointestinal Metastasis From Primary Lung Cancer. Case Series and Systematic Literature Review

2018 ◽  
Vol 96 (4) ◽  
pp. 184-197
Author(s):  
Andrea Balla ◽  
José D. Subiela ◽  
Jesús Bollo ◽  
Carmen Martínez ◽  
Carlos Rodriguez Luppi ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Literature Review ◽  
Systematic Literature Review ◽  
Primary Lung Cancer ◽  
Case Series ◽  
Cancer Case ◽  
Lung Cancer Case ◽  
Gastrointestinal Metastasis
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