scholarly journals Targeting MRP4 expression by anti-androgen treatment reverses MRP4-mediated docetaxel resistance in castration-resistant prostate cancer

2017 ◽  
Vol 14 (2) ◽  
pp. 1748-1756 ◽  
Author(s):  
Yun-Fei Li ◽  
Hui-Hua Ji ◽  
Zheng-Long Zhang ◽  
Tao-Tao Zhang ◽  
Wei Gan ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Castration Resistant Prostate Cancer ◽  
Androgen Treatment ◽  
Docetaxel Resistance ◽  
Castration Resistant

Enzalutamide with or without prior anti-androgen treatment for castration resistant prostate cancer (CRPC): Results from the Dutch CAPRI registry

2018 ◽  
Vol 17 (14) ◽  
pp. e2891-e2893
Author(s):  
M. Kuppen ◽  
H. Westgeest ◽  
F. Van Den Eertwegh ◽  
J. Van Moorselaar ◽  
N. Mehra ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Castration Resistant Prostate Cancer ◽  
Androgen Treatment ◽  
Castration Resistant

EGFR mediates docetaxel resistance in human castration-resistant prostate cancer through the Akt-dependent expression of ABCB1 (MDR1)

2014 ◽  
Vol 89 (4) ◽  
pp. 591-605 ◽  
Author(s):  
Tzyh-Chyuan Hour ◽  
Shiu-Dong Chung ◽  
Wang-Yi Kang ◽  
Ying-Chu Lin ◽  
Shu-Ju Chuang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Castration Resistant Prostate Cancer ◽  
Docetaxel Resistance ◽  
Castration Resistant

Evaluation of Docetaxel-Sensitive and Docetaxel-Resistant Proteomes in PC-3 Cells

2015 ◽  
Vol 95 (1) ◽  
pp. 114-119 ◽  
Author(s):  
Shulu Zu ◽  
Weiming Ma ◽  
Pan Xiao ◽  
Yazhou Cui ◽  
Tianjia Ma ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Molecular Mechanisms ◽  
Polyacrylamide Gel Electrophoresis ◽  
Acquired Resistance ◽  
Castration Resistant Prostate Cancer ◽  
Ionization Time ◽  
Flight Mass Spectrometry ◽  
Docetaxel Resistance ◽  
Castration Resistant ◽  
Glucose Regulated Protein

Objectives: Docetaxel was the first drug with proven survival benefit in men with castration-resistant prostate cancer. Acquired resistance to docetaxel precedes fatality in castration-resistant prostate cancer. The aims of this study were to evaluate docetaxel-sensitive and docetaxel-resistant proteomes in PC-3 cells, and to investigate the molecular mechanism of docetaxel-resistant PC-3 cells. Methods: Docetaxel-resistant PC-3 cells were developed by docetaxel dose escalation. The global profiling of the protein expression was investigated in docetaxel-sensitive and docetaxel-resistant proteomes in PC-3 cells using 2-dimensional polyacrylamide gel electrophoresis/matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Results: Forty-nine differential proteins were found in docetaxel-resistant PC-3 cells in comparison with docetaxel-sensitive PC-3 cells. Expression in 29 proteins was upregulated, whereas expression in 20 proteins was downregulated. ATP synthase and galectin-1 were involved in the formation of tumor vessels; calreticulin, cathepsin D, and cofilin were involved in tumor metastasis, and GRP78 (78-kDa glucose-regulated protein) and microtubule-associated protein-6 were involved in drug resistance of tumor. Conclusion: It is suggested that a proteomic expression difference exists between docetaxel-sensitive and docetaxel-resistant PC-3 cells, which would be helpful for further understanding the molecular mechanisms of docetaxel resistance in PC-3 cells.

scholarly journals Identification of Docetaxel Resistance Genes in Castration-Resistant Prostate Cancer

2011 ◽  
Vol 11 (2) ◽  
pp. 329-339 ◽  
Author(s):  
Mercedes Marín-Aguilera ◽  
Jordi Codony-Servat ◽  
Susana G. Kalko ◽  
Pedro L. Fernández ◽  
Raquel Bermudo ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Resistance Genes ◽  
Castration Resistant Prostate Cancer ◽  
Docetaxel Resistance ◽  
Castration Resistant

Nuclear factor-kappa B and interleukin-6 related docetaxel resistance in castration-resistant prostate cancer

The Prostate ◽  
2012 ◽  
Vol 73 (5) ◽  
pp. 512-521 ◽  
Author(s):  
Jordi Codony-Servat ◽  
Mercedes Marín-Aguilera ◽  
Laura Visa ◽  
Xabier García-Albéniz ◽  
Estela Pineda ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Interleukin 6 ◽  
Nuclear Factor Kappa B ◽  
Nuclear Factor ◽  
Castration Resistant Prostate Cancer ◽  
Nuclear Factor Kappa ◽  
Docetaxel Resistance ◽  
Castration Resistant

TMPRSS2-ERG in Blood and Docetaxel Resistance in Metastatic Castration-resistant Prostate Cancer

2016 ◽  
Vol 70 (5) ◽  
pp. 709-713 ◽  
Author(s):  
Òscar Reig ◽  
Mercedes Marín-Aguilera ◽  
Gemma Carrera ◽  
Natalia Jiménez ◽  
Laia Paré ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Castration Resistant Prostate Cancer ◽  
Docetaxel Resistance ◽  
Castration Resistant

Corrigendum re: “TMPRSS2-ERG in Blood and Docetaxel Resistance in Metastatic Castration-resistant Prostate Cancer” [Eur Urol 2016;70:709–13]

2017 ◽  
Vol 72 (2) ◽  
pp. e49
Author(s):  
Òscar Reig ◽  
Mercedes Marín-Aguilera ◽  
Gemma Carrera ◽  
Natalia Jiménez ◽  
Laia Paré ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Castration Resistant Prostate Cancer ◽  
Docetaxel Resistance ◽  
Castration Resistant

scholarly journals Identification of Key Genes and Molecular Mechanisms Associated With Docetaxel Resistance in Castration Resistant Prostate Cancer Based on Bioinformatics Analysis

2020 ◽  
Author(s):  
Yu Liu ◽  
Changpeng Hu ◽  
Qian Zhang ◽  
Wuyi Liu ◽  
Guobing Li ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Molecular Mechanisms ◽  
Epithelial Mesenchymal Transition ◽  
Castration Resistant Prostate Cancer ◽  
Mesenchymal Transition ◽  
Docetaxel Resistance ◽  
Castration Resistant ◽  
E2f Transcription Factor ◽  
Key Genes

Abstract BackgroundCastration resistant prostate cancer (CRPC) is one of the most common solid tumor with high mortality and limited therapeutic options, and docetaxel is the first-line chemotherapy for patients. However, the long-term use of docetaxel has limited its clinical applications. The aim of this study was to identify docetaxel-resistant key genes and molecular mechanisms. ResultsTUBB4A (Class IVa beta-tubulin), SRPX (Sushi repeat containing protein, X chromosome) and CSRP2 (Cysteine and glycine rich protein 2) were finally identified as the key genes tightly related to docetaxel resistance. TUBB4A and CSRP2 may participate in docetaxel resistance by E2F transcription factor and MYC proto-Oncogene in the process of cell cycle, and SRPX may participate in docetaxel resistance by epithelial–mesenchymal transition (EMT) and P53 pathway. ConclusionTUBB4A, SRPX and CSRP2 may be the key genes associated with docetaxel resistance, which could be prognostic biomarkers for docetaxel resistance in CRPC.

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