scholarly journals The lipid metabolism gene FTO influences breast cancer cell energy metabolism via the PI3K/AKT signaling pathway

2017 ◽  
Vol 13 (6) ◽  
pp. 4685-4690 ◽  
Author(s):  
Yazhuo Liu ◽  
Ruoyu Wang ◽  
Lichuan Zhang ◽  
Jianhua Li ◽  
Keli Lou ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lipid Metabolism ◽  
Energy Metabolism ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Akt Signaling ◽  
Akt Signaling Pathway ◽  
Cell Energy ◽  
Lipid Metabolism Gene ◽  
Metabolism Gene

scholarly journals α-Mangostin Induces Apoptosis and Inhibits Metastasis of Breast Cancer Cells via Regulating RXRα-AKT Signaling Pathway

2021 ◽  
Vol 12 ◽  
Author(s):  
Xiuzhi Zhu ◽  
Jialin Li ◽  
Huiting Ning ◽  
Zhidong Yuan ◽  
Yue Zhong ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Cyclin D1 ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Breast Cancer Cells ◽  
Akt Signaling ◽  
Akt Signaling Pathway

Mangostin, which has the function of anti-inflammatory, antioxidant, and anticancer, etc, is one of the main active ingredients of the hull of the mangosteen. The main objective of the study was to elucidate its anti-cancer function and possible mechanism. α-Mangostin was separated and structurally confirmed. MTT method was used to check the effect of mangostin on breast cancer cell proliferation. Then the effect of α-Mangostin on the transcriptional activity of RXRα was tested by dual-luciferase reporter gene assay. And Western blot (WB) was used to detect the expression of apoptosis-related proteins or cell cycle-associated proteins after treatment. Also, this study was to observe the effects of α-Mangostin on the invasion of breast cancer cell line MDA-MB-231. α-Mangostin regulates the downstream effectors of the PI3K/AKT signaling pathway by degrading RXRα/tRXRα. α-Mangostin can trigger PARP cleavage and induce apoptosis, which may be related to the induction of upregulated BAX expression and downregulation of BAD and cleaved caspase-3 expression in MDA-MB-231 cells through blockade of AKT signaling. The experiments verify that α-Mangostin have evident inhibition effects of invasion and metastasis of MDA-MB-231 cells. Cyclin D1 was involved in the anticancer effects of α-Mangostin on the cell cycle in MDA-MB-231 cells. α-Mangostin induces apoptosis, suppresses the migration and invasion of breast cancer cells through the PI3K/AKT signaling pathway by targeting RXRα, and cyclin D1 has involved in this process.

scholarly journals Mitochondria-targeted vitamin E analogs inhibit breast cancer cell energy metabolism and promote cell death

BMC Cancer ◽  
2013 ◽  
Vol 13 (1) ◽  
Author(s):  
Gang Cheng ◽  
Jacek Zielonka ◽  
Donna M McAllister ◽  
A Craig Mackinnon ◽  
Joy Joseph ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Death ◽  
Vitamin E ◽  
Energy Metabolism ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cell Energy ◽  
Promote Cell Death ◽  
Cell Energy Metabolism

scholarly journals Gemcitabine aggravates miR-199a-5p-mediated breast cancer cell apoptosis by promoting VEGFA downregulationviainactivating the AKT signaling pathway

RSC Advances ◽  
2019 ◽  
Vol 9 (35) ◽  
pp. 20385-20394 ◽  
Author(s):  
Dingmei Deng ◽  
Xian Ye ◽  
Xiyue Wang ◽  
Guangning He
Keyword(s):  
Breast Cancer ◽  
Signaling Pathway ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Late Stage ◽  
Cell Apoptosis ◽  
Akt Signaling ◽  
Akt Signaling Pathway ◽  
Cancer Cell Apoptosis

Breast cancer is the most frequent malignancy diagnosed in women, and Gemcitabine-based therapy is frequently used to treat late-stage breast cancer.

scholarly journals miR-641 Inhibited Cell Proliferation and Induced Apoptosis by Targeting NUCKS1/PI3K/AKT Signaling Pathway in Breast Cancer

2022 ◽  
Vol 2022 ◽  
pp. 1-18
Author(s):  
Li Li ◽  
Da Wei ◽  
Junying Zhang ◽  
Rong Deng ◽  
Jinhai Tang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Cell Lines ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Breast Cancer Cells ◽  
Akt Signaling ◽  
Breast Cancer Cell Lines ◽  
Akt Signaling Pathway

Objective. Studies revealed an important role of microRNAs (miRNAs) in multiple cancers, including breast cancer. In the present study, we evaluated the role and function of miR-641 in breast cancer. Methods. The expression level of miR-641 in breast cancer cell lines (Hs-578T, MCF7, HCC1937, and MAD-MB-231) was determined by real-time PCR. Functional analyses, including CCK-8 assay, transwell assay, wound-healing assay, and apoptosis detection, were carried out to explore the roles of miRNA-641 in malignant behaviors of breast cancer. Luciferase report assay was used to investigate the regulatory association of miRNA-641 with its potential targets. Results. The expression levels of miR-641 were downregulated, while the expression levels of nuclear casein kinase and cyclin-dependent kinase substrate 1 (NUCKS1) were increased in breast cancer cell lines. The in vitro results showed that miR-641 repressed proliferation and migration/invasion and promoted apoptosis of breast cancer cells. NUCKS1, a positive regulator of phosphatidylinositol-3-kinases (PI3K)/protein-serine-threonine kinase (AKT) pathway, was confirmed as a direct target of miR-641. The of treatment of the PI3K agonist, 740Y-P, could abrogate the antioncogenic potentials of miR-641 in breast cancer cells. Conclusion. miR-641 functioned as a tumor suppressor through the PI3K/AKT signaling pathway via targeting NUCKS1 in breast cancer.

Sign in / Sign up

Export Citation Format

Share Document