scholarly journals Renal cell carcinoma with synchronous ipsilateral urothelial carcinoma of the renal pelvis

2017 ◽  
Vol 13 (6) ◽  
pp. 4521-4525 ◽  
Author(s):  
Qun Lu ◽  
Junlong Zhuang ◽  
Hongqian Guo
Keyword(s):  
Renal Cell Carcinoma ◽  
Urothelial Carcinoma ◽  
Cell Carcinoma ◽  
Renal Pelvis ◽  
Renal Cell

scholarly journals Synchronous ipsilateral renal cell carcinoma and urothelial carcinoma of the renal pelvis

2013 ◽  
Vol 3 (1) ◽  
pp. 64 ◽  
Author(s):  
Mike Leveridge ◽  
Phillip A. Isotalo ◽  
Alexander H. Boag ◽  
Jun Kawakami
Keyword(s):  
Renal Cell Carcinoma ◽  
Urothelial Carcinoma ◽  
Cell Carcinoma ◽  
Renal Pelvis ◽  
Renal Cell ◽  
Preoperative Imaging ◽  
Time Of Surgery ◽  
Urological Malignancies ◽  
Carcinome Urothélial ◽  
Fresh Specimen

Renal cell carcinoma (RCC) and urothelial carcinoma of the upperurinary tract are not uncommon urological malignancies. Theirsimultaneous occurrence in a patient is, however, extraordinarilyrare. We report the case of a patient who underwent laparoscopicnephrectomy for suspected RCC. Preoperative imaging wassuspicious for renal pelvic involvement, which was confirmedupon bivalving the fresh specimen at the time of surgery, with thediscovery of a separate urothelium-based lesion. We discuss thisrare occurrence and our management approach.Individuellement, l’hypernéphrome et le carcinome urothélial desvoies urinaires supérieures ne sont pas des tumeurs urologiquesrares. Leur survenue simultanée chez un même patient est cependantextrêmement rare. La reconnaissance préopératoire ou intraopératoireest cruciale afin que soit effectuée la résection urétéralerequise. Nous décrivons un cas d’hypernéphrome et de carcinomeurothélial simultanés et homolatéraux.

scholarly journals A DNA adductome analysis revealed a reduction in the global level of C5-hydroxymethyl-2′-deoxycytidine in the non-tumoral upper urinary tract mucosa of urothelial carcinoma patients

2021 ◽  
Vol 43 (1) ◽  
Author(s):  
Yuto Matsushita ◽  
Yuji Iwashita ◽  
Shunsuke Ohtsuka ◽  
Ippei Ohnishi ◽  
Takashi Yamashita ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Urinary Tract ◽  
Urothelial Carcinoma ◽  
Cell Carcinoma ◽  
Dna Adducts ◽  
Renal Pelvis ◽  
Renal Cell ◽  
Renal Cortex ◽  
Upper Urinary Tract ◽  
Urinary Tract Urothelial Carcinoma

Abstract Background DNA adducts, covalent modifications to DNA due to exposure to specific carcinogens, cause the mispairing of DNA bases, which ultimately results in DNA mutations. DNA methylation in the promoter region, another type of DNA base modification, alters the DNA transcription process, and has been implicated in carcinogenesis in humans due to the down-regulation of tumor suppressor genes. Difficulties are associated with demonstrating the existence of DNA adducts or chemically modified bases in the human urological system. Apart from aristolochic acid-DNA adducts, which cause urothelial carcinoma and endemic nephropathy in a particular geographical area (Balkan), limited information is currently available on DNA adduct profiles in renal cell carcinoma and upper urinary tract urothelial carcinoma, including renal pelvic cancer and ureteral cancer. Method To elucidate the significance of DNA adducts in carcinogenesis in the urothelial system, we investigated 53 DNA adducts in the non-tumoral renal parenchyma and non-tumoral renal pelvis of patients with renal cell carcinoma, upper urinary tract urothelial carcinoma, and other diseases using liquid chromatography coupled with tandem mass spectrometry. A comparative analysis of tissue types, the status of malignancy, and clinical characteristics, including lifestyle factors, was performed. Results C5-Methyl-2′-deoxycytidine, C5-hydroxymethyl-2′-deoxycytidine (5hmdC), C5-formyl-2′-deoxycytidine, 2′-deoxyinosine, C8-oxo-2′-deoxyadenosine, and C8-oxo-2′-deoxyguanosine (8-OHdG) were detected in the renal parenchyma and renal pelvis. 8-OHdG was more frequently detected in the renal pelvis than in the renal cortex and medulla (p = 0.048 and p = 0.038, respectively). 5hmdC levels were significantly lower in the renal pelvis of urothelial carcinoma patients (n = 10) than in the urothelium of patients without urothelial carcinoma (n = 15) (p = 0.010). Regarding 5hmdC levels in the renal cortex and medulla, Spearman’s rank correlation test revealed a negative correlation between age and 5hmdC levels (r = − 0.46, p = 0.018 and r = − 0.45, p = 0.042, respectively). Conclusions The present results revealed a reduction of 5hmdC levels in the non-tumoral urinary tract mucosa of patients with upper urinary tract urothelial carcinoma. Therefore, the urothelial cell epithelia of patients with upper urinary tract cancer, even in non-cancerous areas, may be predisposed to urothelial cancer.

scholarly journals Synchronous urothelial carcinoma of renal pelvis and ipsilateral renal cell carcinoma

2017 ◽  
Vol 6 (2) ◽  
pp. 110
Author(s):  
JayalakshmyPayippat Leelamma ◽  
Lillykutty Pothen ◽  
NairParvati Ramachandran
Keyword(s):  
Renal Cell Carcinoma ◽  
Urothelial Carcinoma ◽  
Cell Carcinoma ◽  
Renal Pelvis ◽  
Renal Cell

scholarly journals Clear cell renal cell carcinoma located in sinus renalis confused with renal pelvis mass in image

2015 ◽  
Vol 2 (3) ◽  
pp. 185-186
Author(s):  
Pengjie Wu ◽  
Dong Wei ◽  
Liqing Zhang ◽  
Shumin Deng ◽  
Gang Zhu ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Pelvis ◽  
Renal Cell ◽  
Clear Cell ◽  
Cell Renal Cell Carcinoma

Simultaneous Occurrence of Chromophobe Renal Cell Carcinoma and Urothelial Carcinoma in the Same Kidney

2009 ◽  
Vol 50 (5) ◽  
pp. 508 ◽  
Author(s):  
Ik Joon Choi ◽  
Sung Hwan Jung ◽  
Won Ik Seo ◽  
Pil Moon Kang ◽  
Soo Jin Jung ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Urothelial Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Chromophobe Renal Cell Carcinoma ◽  
Simultaneous Occurrence

PD-L1 Assay Concordance in Metastatic Renal Cell Carcinoma and Metastatic Urothelial Carcinoma

2020 ◽  
Vol 18 (6) ◽  
pp. 509-513
Author(s):  
Landon C. Brown ◽  
Jason Zhu ◽  
Matthew K. Labriola ◽  
Yuan Wu ◽  
Sachica Cheris ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Urothelial Carcinoma ◽  
Cell Carcinoma ◽  
Metastatic Renal Cell Carcinoma ◽  
Renal Cell ◽  
Metastatic Urothelial Carcinoma
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