scholarly journals miR-185 enhances the inhibition of proliferation and migration induced by ionizing radiation in melanoma

2017 ◽  
Vol 13 (4) ◽  
pp. 2442-2448 ◽  
Author(s):  
Jinpeng He ◽  
Ning Tian ◽  
Yanli Yang ◽  
Liangliang Jin ◽  
Xiu Feng ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Inhibition Of Proliferation ◽  
And Migration ◽  
Proliferation And Migration

scholarly journals Protective Effect of Silymarin against Rapamycin-induced Apoptosis and Proliferation Inhibition in Endothelial Progenitor Cells

2015 ◽  
Vol 10 (2) ◽  
pp. 1934578X1501000 ◽  
Author(s):  
Peng Zhang ◽  
Guohua Han ◽  
Pei Gao ◽  
Kun Qiao ◽  
Yusheng Ren ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Mononuclear Cells ◽  
Control Group ◽  
Dependent Manner ◽  
Endothelial Progenitor ◽  
Concentration Dependent Manner ◽  
Inhibition Of Proliferation ◽  
And Migration ◽  
Proliferation And Migration

For this study, peripheral blood samples were collected from human volunteers. Mononuclear cells (MNC) were separated by density centrifugation and were induced to differentiate into endothelial progenitor cells (EPCs) in vitro. Different concentrations of rapamycin and silymarin were introduced to the EPCs over 24 hours and then EPCs were analyzed for proliferation, migration, apoptosis and angiogenesis. Compared with the control group, rapamycin (1, 10, 100 ng/mL) inhibited the proliferation and migration of EPCs in a concentration dependent manner ( P<0.05). Silymarin (50, 100 μg/mL) enhanced the proliferation and migration of EPCs and inhibited apoptosis in a concentration dependent manner ( P<0.05). By adding rapamycin (1 ng/mL) and silymarin (25, 50, 100 μg/mL) over 24 hours, silymarin inhibited the pro-apoptotic effect of rapamycin on EPCs, and reversed the inhibition of proliferation, migration and angiogenesis of EPCs by rapamycin ( P<0.05).

Inhibition of proliferation and migration by piceatannol in vascular smooth muscle cells

2009 ◽  
Vol 23 (7) ◽  
pp. 1284-1291 ◽  
Author(s):  
Beobyi Lee ◽  
Eo-Jin Lee ◽  
Dong-Il Kim ◽  
Sung-kyu Park ◽  
Wun-Jae Kim ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Inhibition Of Proliferation ◽  
And Migration ◽  
Proliferation And Migration

Abstract 332: Inhibition of the Enhancer of Zeste Homolog Family Mitigates Intimal Hyperplasia in Rat Carotid Arteries

2017 ◽  
Vol 37 (suppl_1) ◽  
Author(s):  
Mengxue Zhang ◽  
Bowen Wang ◽  
Go Urabe ◽  
Xudong Shi ◽  
Lian-Wang Guo
Keyword(s):  
Intimal Hyperplasia ◽  
Transcriptional Repression ◽  
Vascular Diseases ◽  
Inhibition Of Proliferation ◽  
Enhancer Of Zeste ◽  
Dual Inhibition ◽  
And Migration ◽  
Proliferation And Migration

Rationale: The enhancer of zeste homologs 1 and 2 (EZH1 and EZH2) are histone-lysine N-methyltransferases that modify histones by methylation which leads to transcriptional repression. It has recently been shown that EZH1 and EZH2 play an important role in various cancers. Whether they play a role in recurrent vascular diseases is not known. Objective: We assessed whether EZH1 and EZH2 are important contributors to the development of intimal hyperplasia (IH) and restenosis. Methods and Results: Following rat carotid balloon angioplasty, EZH2 showed highest expression at day 3 post procedure and then decreased at day 7 in injured arteries, as determined by Western blotting. Change of EZH1 is less prominent. Dual inhibition of EZH1 and EZH2 through peri-adventitial administration of a selective inhibitor, UNC-1999, effectively inhibited intimal hyperplasia, with ~40% reduction in the ratio of intima to media (I/M). Moreover, in cultured primary rat smooth muscle cells (SMCs) as well as MOVAS cells, pretreatment with 5μM UNC-1999 resulted in a 60% decrease in cell proliferation and ~80% reduction of migration that were stimulated by PDGF-BB. Simultaneous knockdown of EZH1 and EZH2, as well as knockdown of their shared scaffold protein(EED), led to effective inhibition of proliferation and migration of SMCs. However, knockdown of EZH2 alone did not recapitulate the effects of dual inhibition of EZH1 and EZH2. Conclusions: This study demonstrates that dual inhibition of EZH1 and EZH2, both histone modifiers, mitigates intimal hyperplasia in vivo and attenuates PDGF-BB stimulated SMC proliferation and migration in vitro.

scholarly journals Inhibition of proliferation and migration of melanoma cells by ketoconazole and Ganoderma immunomodulatory proteins

2019 ◽  
Author(s):  
Chun‑Te Lu ◽  
Pui‑Ying Leong ◽  
Ting‑Yi Hou ◽  
Yu‑Ting Kang ◽  
Yan‑Cheng Chiang ◽  
...  
Keyword(s):  
Melanoma Cells ◽  
Inhibition Of Proliferation ◽  
And Migration ◽  
Proliferation And Migration

scholarly journals The LIM-Only Protein FHL2 Reduces Vascular Lesion Formation Involving Inhibition of Proliferation and Migration of Smooth Muscle Cells

PLoS ONE ◽  
2014 ◽  
Vol 9 (4) ◽  
pp. e94931 ◽  
Author(s):  
Kondababu Kurakula ◽  
Mariska Vos ◽  
Iker Otermin Rubio ◽  
Goran Marinković ◽  
Reinhard Buettner ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Muscle Cells ◽  
Vascular Lesion ◽  
Lesion Formation ◽  
Inhibition Of Proliferation ◽  
And Migration ◽  
Proliferation And Migration
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