scholarly journals ALDH1 and podoplanin expression patterns predict the risk of malignant transformation in oral leukoplakia

2016 ◽  
Vol 13 (1) ◽  
pp. 321-328 ◽  
Author(s):  
Umma Habiba ◽  
Kyoko Hida ◽  
Tetsuya Kitamura ◽  
Aya Yanagawa Matsuda ◽  
Fumihiro Higashino ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Expression Patterns ◽  
Oral Leukoplakia ◽  
Podoplanin Expression

378: 14-3-3 Expression Patterns in the Human Kidney: From Fetal Development to the Adult State to Malignant Transformation

2005 ◽  
Vol 173 (4S) ◽  
pp. 103-103
Author(s):  
Adam G. Baseman ◽  
Andrew J. Kirsch ◽  
Fray F. Marshall ◽  
Haiyen E. Zhau ◽  
Leland W.K. Chung ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Fetal Development ◽  
Expression Patterns ◽  
Human Kidney

scholarly journals Importance of the PD-1/PD-L1 Axis for Malignant Transformation and Risk Assessment of Oral Leukoplakia

Biomedicines ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 194
Author(s):  
Jutta Ries ◽  
Abbas Agaimy ◽  
Falk Wehrhan ◽  
Christoph Baran ◽  
Stella Bolze ◽  
...  
Keyword(s):  
Immune Response ◽  
Cell Death ◽  
Programmed Cell Death ◽  
Malignant Transformation ◽  
Immune Escape ◽  
Checkpoint Inhibitors ◽  
Precancerous Lesions ◽  
Death Receptor ◽  
Oral Leukoplakia ◽  
Significant Difference

Background: The programmed cell death ligand 1/programmed cell death receptor 1 (PD-L1/PD-1) Immune Checkpoint is an important modulator of the immune response. Overexpression of the receptor and its ligands is involved in immunosuppression and the failure of an immune response against tumor cells. PD-1/PD-L1 overexpression in oral squamous cell carcinoma (OSCC) compared to healthy oral mucosa (NOM) has already been demonstrated. However, little is known about its expression in oral precancerous lesions like oral leukoplakia (OLP). The aim of the study was to investigate whether an increased expression of PD-1/PD-L1 already exists in OLP and whether it is associated with malignant transformation. Material and Methods: PD-1 and PD-L1 expression was immunohistologically analyzed separately in the epithelium (E) and the subepithelium (S) of OLP that had undergone malignant transformation within 5 years (T-OLP), in OLP without malignant transformation (N-OLP), in corresponding OSCC and in NOM. Additionally, RT-qPCR analysis for PD-L1 expression was done in the entire tissues. Additionally, the association between overexpression and malignant transformation, dysplasia and inflammation were examined. Results: Compared to N-OLP, there were increased levels of PD-1 protein in the epithelial and subepithelial layers of T-OLP (pE = 0.001; pS = 0.005). There was no significant difference in PD-L1 mRNA expression between T-OLP and N-OLP (p = 0.128), but the fold-change increase between these groups was significant (Relative Quantification (RQ) = 3.1). In contrast to N-OLP, the PD-L1 protein levels were significantly increased in the epithelial layers of T-OLP (p = 0.007), but not in its subepithelial layers (p = 0.25). Importantly, increased PD-L1 levels were significantly associated to malignant transformation within 5 years. Conclusion: Increased levels of PD-1 and PD-L1 are related to malignant transformation in OLP and may represent a promising prognostic indicator to determine the risk of malignant progression of OLP. Increased PD-L1 levels might establish an immunosuppressive microenvironment, which could favor immune escape and thereby contribute to malignant transformation. Hence, checkpoint inhibitors could counteract tumor development in OLP and may serve as efficient therapeutic strategy in patients with high-risk precancerous lesions.

scholarly journals Candida in malignant transformation of oral leukoplakia: A review

2020 ◽  
Vol 4 (1) ◽  
pp. 3-6
Author(s):  
Pooja Rathod ◽  
Manjushri Waingade ◽  
Madhura Mahajan ◽  
Daya K. Jangam
Keyword(s):  
Malignant Transformation ◽  
Oral Leukoplakia

Nomogram for risk prediction of malignant transformation in oral leukoplakia patients using combined biomarkers

Oral Oncology ◽  
2017 ◽  
Vol 72 ◽  
pp. 132-139 ◽  
Author(s):  
Xianglan Zhang ◽  
Ki-Yeol Kim ◽  
Zhenlong Zheng ◽  
Shadavlonjid Bazarsad ◽  
Jin Kim
Keyword(s):  
Malignant Transformation ◽  
Risk Prediction ◽  
Oral Leukoplakia

Association between hyperglycemia and the malignant transformation of oral leukoplakia in China

Oral Diseases ◽  
2020 ◽  
Vol 26 (7) ◽  
pp. 1402-1413
Author(s):  
Jin Li ◽  
Yang Liu ◽  
Hua Zhang ◽  
Hong Hua
Keyword(s):  
Malignant Transformation ◽  
Oral Leukoplakia
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