scholarly journals Co-culture of hepatoma cells with hepatocytic precursor (stem-like) cells inhibits tumor cell growth and invasion by downregulating Akt/NF-κB expression

2016 ◽  
Vol 12 (5) ◽  
pp. 4054-4060
Author(s):  
Cheng-Jun Sui ◽  
Miao Xu ◽  
Wei-Qing Li ◽  
Jia-Mei Yang ◽  
Hong-Zhu Yan ◽  
...  
Keyword(s):  
Cell Growth ◽  
Tumor Cell ◽  
Hepatoma Cells ◽  
Tumor Cell Growth

Vitronetcin promotes cell growth and inhibits apoptotic stimuli in a human hepatoma cell line via the activation of caspases

2014 ◽  
Vol 92 (5) ◽  
pp. 363-368 ◽  
Author(s):  
Wei Zhu ◽  
Yingzhi Liu ◽  
Konghe Hu ◽  
Wenxue Li ◽  
Jianling Chen ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Cell Growth ◽  
Tumor Cell ◽  
Hepatoma Cell ◽  
Hepatoma Cells ◽  
Signaling Molecules ◽  
Hepatoma Cell Line ◽  
Dependent Manner ◽  
Tumor Cell Growth ◽  
Induced Apoptosis

This study sought to understand the effects of vitronectin (VTN) on the growth of SMMC-7721 hepatoma cells. In addition, this study examined how VTN inhibits the induction of apoptosis in SMMC-7721 cells by 3,3′-diindolylmethane (DIM), a metabolite of natural phytochemicals, and preliminarily investigated the signaling molecules involved in this process. A cell proliferation reagent was used to observe the effects of VTN on cell proliferation rates. Laser scanning confocal microscopy was performed to observe the effects of VTN on the morphology of tubulin, a component of the cytoskeleton. Flow cytometry and Western blotting assays were used to observe the inhibitory effects of VTN on DIM-induced apoptosis in SMMC-7721 cells and changes in the expression levels of the signaling molecules involved in this process. VTN promoted tumor cell growth in a concentration-dependent manner and inhibited apoptosis caused by the effects of apoptosis-inducing agents. Under in vitro experimental conditions, VTN contributed to the growth of SMMC-7721 hepatoma cells and protected them from the effects of an apoptosis-inducing agent. These findings suggest that during hepatocellular carcinogenesis, VTN may promote tumor cell growth and inhibit chemically induced apoptosis.

scholarly journals Structural and stereochemical studies of potent inhibitors of glucosylceramide synthase and tumor cell growth.

1995 ◽  
Vol 36 (3) ◽  
pp. 611-621
Author(s):  
A Abe ◽  
N S Radin ◽  
J A Shayman ◽  
L L Wotring ◽  
R E Zipkin ◽  
...  
Keyword(s):  
Cell Growth ◽  
Tumor Cell ◽  
Tumor Cell Growth ◽  
Glucosylceramide Synthase

Bcl-2 targeting siRNA expressed by a T7 vector system inhibits human tumor cell growth in vitro

2004 ◽  
Author(s):  
Lori Holle ◽  
Labri Hicks ◽  
Wendy Song ◽  
Eric Holle ◽  
Thomas Wagner ◽  
...  
Keyword(s):  
Cell Growth ◽  
Tumor Cell ◽  
Human Tumor ◽  
Vector System ◽  
Tumor Cell Growth ◽  
Human Tumor Cell

scholarly journals Differential effect of subcellular localization of communication impairing gap junction protein connexin43 on tumor cell growth in vivo

Oncogene ◽  
2000 ◽  
Vol 19 (4) ◽  
pp. 505-513 ◽  
Author(s):  
V A Krutovskikh ◽  
S M Troyanovsky ◽  
C Piccoli ◽  
H Tsuda ◽  
M Asamoto ◽  
...  
Keyword(s):  
Cell Growth ◽  
Subcellular Localization ◽  
Tumor Cell ◽  
Gap Junction ◽  
Differential Effect ◽  
Tumor Cell Growth ◽  
Junction Protein ◽  
Gap Junction Protein

IL2/IL-4, OX40L and FDC-like cell line support the in vitro tumor cell growth of adult T-cell leukemia/lymphoma

2014 ◽  
Vol 38 (5) ◽  
pp. 608-612 ◽  
Author(s):  
Dai Chihara ◽  
Yoshitoyo Kagami ◽  
Harumi Kato ◽  
Noriaki Yoshida ◽  
Tohru Kiyono ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Growth ◽  
Tumor Cell ◽  
Cell Line ◽  
Tumor Cell Growth ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Adult T Cell Leukemia

scholarly journals Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists

2007 ◽  
Vol 104 (20) ◽  
pp. 8455-8460 ◽  
Author(s):  
M. Lauth ◽  
A. Bergstrom ◽  
T. Shimokawa ◽  
R. Toftgard
Keyword(s):  
Cell Growth ◽  
Tumor Cell ◽  
Small Molecule ◽  
Tumor Cell Growth
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