scholarly journals Beside P53 and PTEN: Identification of molecular alterations of the RAS/MAPK and PI3K/AKT signaling pathways in high-grade serous ovarian carcinomas to determine potential novel therapeutic targets

2016 ◽  
Vol 12 (5) ◽  
pp. 3264-3272 ◽  
Author(s):  
Shuhui Chen ◽  
Elisa Cavazza ◽  
Catherine Barlier ◽  
Julia Salleron ◽  
Pierre Filhine-Tresarrieu ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Therapeutic Targets ◽  
Akt Signaling ◽  
High Grade ◽  
Ovarian Carcinomas ◽  
Molecular Alterations ◽  
Novel Therapeutic

PETAL: a python tool for deep analysis of biological pathways

2020 ◽  
Author(s):  
Giuseppe Sgroi ◽  
Giulia Russo ◽  
Francesco Pappalardo
Keyword(s):  
Open Source ◽  
Signaling Pathways ◽  
Open Source Software ◽  
Kegg Pathway ◽  
Source Code ◽  
Therapeutic Targets ◽  
Biological Pathways ◽  
Long Distance ◽  
Bioinformatics Tools ◽  
Novel Therapeutic

Abstract Summary Although several bioinformatics tools have been developed to examine signaling pathways, little attention has been given to ever long-distance crosstalk mechanisms. Here, we developed PETAL, a Python tool that automatically explores and detects the most relevant nodes within a KEGG pathway, scanning and performing an in-depth search. PETAL can contribute to discovering novel therapeutic targets or biomarkers that are potentially hidden and not considered in the network under study. Availability PETAL is a freely available open-source software. It runs on all platforms that support Python3. The user manual and source code are accessible from https://github.com/Pex2892/PETAL.

Pathophysiology of cardiac hypertrophy and heart failure: signaling pathways and novel therapeutic targets

2015 ◽  
Vol 89 (9) ◽  
pp. 1401-1438 ◽  
Author(s):  
Yow Keat Tham ◽  
Bianca C. Bernardo ◽  
Jenny Y. Y. Ooi ◽  
Kate L. Weeks ◽  
Julie R. McMullen
Keyword(s):  
Heart Failure ◽  
Cardiac Hypertrophy ◽  
Signaling Pathways ◽  
Therapeutic Targets ◽  
Novel Therapeutic

scholarly journals Common Molecular Alterations in Canine Oligodendroglioma and Human Malignant Gliomas and Potential Novel Therapeutic Targets

2019 ◽  
Vol 9 ◽  
Author(s):  
Dana Mitchell ◽  
Sreenivasulu Chintala ◽  
Kaleigh Fetcko ◽  
Mario Henriquez ◽  
Brij N. Tewari ◽  
...  
Keyword(s):  
Malignant Gliomas ◽  
Therapeutic Targets ◽  
Molecular Alterations ◽  
Novel Therapeutic
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