scholarly journals Cancer stem cells as a potential therapeutic target in thyroid carcinoma

2016 ◽  
Vol 12 (4) ◽  
pp. 2254-2260 ◽  
Author(s):  
Luisa Vicari ◽  
Cristina Colarossi ◽  
Dario Giuffrida ◽  
Ruggero De Maria ◽  
Lorenzo Memeo
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Thyroid Carcinoma ◽  
Therapeutic Target ◽  
Potential Therapeutic Target

Wilms Tumor NCAM-Expressing Cancer Stem Cells as Potential Therapeutic Target for Polymeric Nanomedicine

2017 ◽  
Vol 16 (11) ◽  
pp. 2462-2472 ◽  
Author(s):  
Ela Markovsky ◽  
Einav Vax ◽  
Dikla Ben-Shushan ◽  
Anat Eldar-Boock ◽  
Rachel Shukrun ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Therapeutic Target ◽  
Wilms Tumor ◽  
Potential Therapeutic Target

scholarly journals Mevalonate Metabolism Regulates Basal Breast Cancer Stem Cells and Is a Potential Therapeutic Target

Stem Cells ◽  
2012 ◽  
Vol 30 (7) ◽  
pp. 1327-1337 ◽  
Author(s):  
Christophe Ginestier ◽  
Florence Monville ◽  
Julien Wicinski ◽  
Olivier Cabaud ◽  
Nathalie Cervera ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Therapeutic Target ◽  
Breast Cancer Stem Cells ◽  
Potential Therapeutic Target ◽  
Basal Breast Cancer

scholarly journals The Roles of Autophagy in Cancer

2018 ◽  
Vol 19 (11) ◽  
pp. 3466 ◽  
Author(s):  
Chul Yun ◽  
Sang Lee
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Cancer Treatment ◽  
Therapeutic Target ◽  
Tumor Suppression ◽  
Anticancer Therapy ◽  
Nutrient Deprivation ◽  
Dual Roles ◽  
Potential Therapeutic Target ◽  
Development Of Resistance

Autophagy is an intracellular degradative process that occurs under several stressful conditions, including organelle damage, the presence of abnormal proteins, and nutrient deprivation. The mechanism of autophagy initiates the formation of autophagosomes that capture degraded components and then fuse with lysosomes to recycle these components. The modulation of autophagy plays dual roles in tumor suppression and promotion in many cancers. In addition, autophagy regulates the properties of cancer stem-cells by contributing to the maintenance of stemness, the induction of recurrence, and the development of resistance to anticancer reagents. Although some autophagy modulators, such as rapamycin and chloroquine, are used to regulate autophagy in anticancer therapy, since this process also plays roles in both tumor suppression and promotion, the precise mechanism of autophagy in cancer requires further study. In this review, we will summarize the mechanism of autophagy under stressful conditions and its roles in tumor suppression and promotion in cancer and in cancer stem-cells. Furthermore, we discuss how autophagy is a promising potential therapeutic target in cancer treatment.

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