scholarly journals Effective hepatic artery chemoembolization for advanced hepatocellular carcinoma with multiple tumor thrombi and pulmonary metastases: A case report

2016 ◽  
Vol 12 (3) ◽  
pp. 2103-2106
Author(s):  
De-Jia Huang ◽  
Yan-Hao Li ◽  
Yao-Chang Luo ◽  
Jun-Zhen Huang ◽  
Hai-Yuan He
Keyword(s):  
Hepatocellular Carcinoma ◽  
Case Report ◽  
Hepatic Artery ◽  
Pulmonary Metastases ◽  
Advanced Hepatocellular Carcinoma ◽  
Multiple Tumor ◽  
Hepatic Artery Chemoembolization ◽  
Tumor Thrombi

scholarly journals Impact of Extrahepatic Metastases on Overall Survival in Patients with Advanced Liver Dominant Hepatocellular Carcinoma: A Subanalysis of the SORAMIC Trial

Liver Cancer ◽  
2020 ◽  
Vol 9 (6) ◽  
pp. 771-786
Author(s):  
Kerstin Schütte ◽  
Regina Schinner ◽  
Mathias P. Fabritius ◽  
Melina Möller ◽  
Christiane Kuhl ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Median Survival ◽  
Pulmonary Metastases ◽  
Study Entry ◽  
Extrahepatic Disease ◽  
Advanced Hepatocellular Carcinoma ◽  
Significant Difference ◽  
Distant Organ ◽  
Extrahepatic Metastases ◽  
The Impact

<b><i>Introduction:</i></b> Extrahepatic spread is reported as a prognostic factor in patients with advanced hepatocellular carcinoma (HCC) receiving systemic therapy. However, clinical studies have reported conflicting results for the clinical impact of the pattern of tumor progression during treatment and the role of new extrahepatic metastases in length of survival. <b><i>Objective:</i></b> To evaluate the impact of extrahepatic metastases on survival in patients with HCC treated with sorafenib or with a combination of sorafenib and selective internal radiation treatment (SIRT). <b><i>Methods:</i></b> SORAMIC is a randomized, controlled trial comprising diagnostic, local ablation, and palliative cohorts. In the palliative cohort, patients not eligible for transarterial chemoembolization (TACE) were randomized 11:10 to SIRT plus sorafenib (SIRT + sorafenib) or sorafenib alone. This exploratory subanalysis evaluated the impact of extrahepatic metastases on survival. <b><i>Results:</i></b> In the intent-to-treat cohort, 216 patients were randomized to SIRT + sorafenib and 208 to sorafenib alone. Seventeen patients with distant organ metastases (bone, <i>n</i> = 11; adrenal glands, <i>n</i> = 5; peritoneum, <i>n</i> = 1) and 262 without distant metastases at study entry were analyzed in this substudy. Patients with (Group A) and without (Group B) distant organ metastases at study entry presented with a median survival of 11.3 and 14.8 months, respectively (<i>p</i> = 0.2807). During follow-up of patients with no organ metastases at baseline, extrahepatic disease progression occurred in 50 patients (19.1%). No statistically significant difference in survival was observed between patients without extrahepatic progression and those with new extrahepatic disease during treatment (14.8 vs. 14.9 months; <i>p</i> = 0.6483). Development of new pulmonary metastases during treatment significantly shortened median survival (7.6 vs. 15.0 months, <i>p</i> = 0.0060). <b><i>Conclusions:</i></b> This subanalysis of the SORAMIC trial suggests that in patients with liver-dominant advanced HCC, metastases to distant organs with the exception of pulmonary metastases do not in general exert a negative impact on patient prognosis. The choice of palliative treatment should incorporate a personalized analysis of the pattern of tumor distribution.

Complete Histologic Response Induced by Sorafenib in Advanced Hepatocellular Carcinoma: A Case Report

2011 ◽  
Vol 29 (12) ◽  
pp. e330-e332 ◽  
Author(s):  
Elsa Curtit ◽  
Antoine Thiery-Vuillemin ◽  
Thierry Nguyen ◽  
Bruno Heyd ◽  
Xavier Pivot ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Case Report ◽  
Advanced Hepatocellular Carcinoma ◽  
Histologic Response

Complete Response of Advanced Hepatocellular Carcinoma with Multiple Lung Metastases Treated with Sorafenib: A Case Report

Oncology ◽  
2011 ◽  
Vol 81 (s1) ◽  
pp. 152-157 ◽  
Author(s):  
Tadashi Inuzuka ◽  
Hiroki Nishikawa ◽  
Akira Sekikawa ◽  
Haruhiko Takeda ◽  
Shinichiro Henmi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Case Report ◽  
Lung Metastases ◽  
Complete Response ◽  
Advanced Hepatocellular Carcinoma

Complete response by vitamin K2 analog monotherapy in sorafenib‐failure advanced hepatocellular carcinoma: A case report

2018 ◽  
Vol 49 (3) ◽  
pp. 360-364 ◽  
Author(s):  
Teiji Kuzuya ◽  
Masatoshi Ishigami ◽  
Yoji Ishizu ◽  
Takashi Honda ◽  
Kazuhiko Hayashi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Case Report ◽  
Complete Response ◽  
Vitamin K2 ◽  
Advanced Hepatocellular Carcinoma

AFP Measurement in Monitoring Treatment Response of Advanced Hepatocellular Carcinoma to Sorafenib: Case Report and Review of the Literature

Onkologie ◽  
2011 ◽  
Vol 34 (10) ◽  
pp. 538-542 ◽  
Author(s):  
Thomas Gamstätter ◽  
Arndt Weinmann ◽  
Simin Schadmand-Fischer ◽  
Pia R. Spies ◽  
Ina M. Niederle ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Case Report ◽  
Treatment Response ◽  
Advanced Hepatocellular Carcinoma ◽  
Review Of The Literature ◽  
Monitoring Treatment ◽  
Monitoring Treatment Response

scholarly journals Long-term follow-up of complete remission of advanced hepatocellular carcinoma following sorafenib therapy: A case report

2017 ◽  
Vol 14 (4) ◽  
pp. 4853-4856 ◽  
Author(s):  
Jung Gil Park ◽  
Won Young Tak ◽  
Soo Young Park ◽  
Young Oh Kweon ◽  
Se Young Jang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Case Report ◽  
Complete Remission ◽  
Advanced Hepatocellular Carcinoma ◽  
Sorafenib Therapy ◽  
Long Term Follow Up

scholarly journals Hepatic Artery Chemoembolization for Hepatocellular Carcinoma in Patients Listed for Liver Transplantation

2004 ◽  
Vol 4 (5) ◽  
pp. 782-787 ◽  
Author(s):  
Paul H. Hayashi ◽  
Michael Ludkowski ◽  
Lisa M. Forman ◽  
Michael Osgood ◽  
Stephen Johnson ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Hepatic Artery ◽  
Hepatic Artery Chemoembolization
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