scholarly journals Sinomenine inhibits A549 human lung cancer cell invasion by mediating the STAT3 signaling pathway

2016 ◽  
Vol 12 (2) ◽  
pp. 1380-1386 ◽  
Author(s):  
Shulong Jiang ◽  
Yebo Gao ◽  
Wei Hou ◽  
Rui Liu ◽  
Xin Qi ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Signaling Pathway ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Cancer Cell Invasion ◽  
Lung Cancer Cell ◽  
Stat3 Signaling ◽  
Stat3 Signaling Pathway

scholarly journals ERK3 signals through SRC-3 coactivator to promote human lung cancer cell invasion

2012 ◽  
Vol 122 (5) ◽  
pp. 1869-1880 ◽  
Author(s):  
Weiwen Long ◽  
Charles E. Foulds ◽  
Jun Qin ◽  
Jian Liu ◽  
Chen Ding ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Cancer Cell Invasion ◽  
Lung Cancer Cell ◽  
Human Lung Cancer Cell

scholarly journals Parthenolide inhibits human lung cancer cell growth by modulating the IGF‑1R/PI3K/Akt signaling pathway

2020 ◽  
Vol 44 (3) ◽  
pp. 1184-1193
Author(s):  
Longhua Sun ◽  
Wenxin Yuan ◽  
Guilan Wen ◽  
Bentong Yu ◽  
Fei Xu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Growth ◽  
Signaling Pathway ◽  
Cancer Cell ◽  
Human Lung ◽  
Akt Signaling ◽  
Human Lung Cancer ◽  
Akt Signaling Pathway ◽  
Lung Cancer Cell ◽  
Cancer Cell Growth

scholarly journals Identification of the Sixth Ig-like Domain of VCAM-1 as a Novel Therapeutic Target in Lung Cancer Cell Invasion

2017 ◽  
Author(s):  
Mi Ra Kim ◽  
Ji Hye Jang ◽  
Chang Sik Park ◽  
Taek-Keun Kim ◽  
Youn-Jae Kim ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Therapeutic Target ◽  
Human Lung Cancer ◽  
Normal Lung ◽  
Cancer Cell Invasion ◽  
Lung Cancer Cell ◽  
Synthetic Antibody ◽  
Novel Therapeutic

Vascular cell adhesion molecule-1 (VCAM-1) is closely associated with tumor progression and metastasis. However, the relevance and role of VCAM-1 in lung cancer have not been clearly elucidated. In this study, we found that VCAM-1 was highly overexpressed in lung cancer tissue compared with that of normal lung, and high VCAM-1 expression correlated with poor survival of lung cancer patients. VCAM-1 knockdown reduced invasion in A549 human lung cancer cells, and competitive blocking experiments targeting the Ig-like domain 6 of VCAM-1 (VCAM-1-D6) demonstrated that the VCAM-1-D6 domain was critical for VCAM-1-mediated A549 cell invasion. Next, we developed a human monoclonal antibody specific to human and mouse VCAM-1-D6 (VCAM-1-D6 huMab), which was isolated from a human synthetic antibody library using phage display technology. Finally, we showed that VCAM-1-D6 huMab had a nanomolar affinity for VCAM-1-D6 and that it potently suppressed invasion in A549 and NCI-H1299 lung cancer cell lines. Taken together, these results suggest that VCAM-1-D6 is a novel therapeutic target in VCAM-1-mediated lung cancer invasion and that our newly developed VCAM-1-D6 huMab will be a useful tool for inhibiting VCAM-1-expressing lung cancer cell invasion.

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