scholarly journals miR-199a-5p induces cell invasion by suppressing E-cadherin expression in cutaneous squamous cell carcinoma

2016 ◽  
Vol 12 (1) ◽  
pp. 97-101 ◽  
Author(s):  
SHAOHUA WANG ◽  
KE CAO ◽  
QUANYONG HE ◽  
ZHAOQI YIN ◽  
JIANDA ZHOU
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cell Invasion ◽  
Cutaneous Squamous Cell Carcinoma ◽  
E Cadherin

Expression of E-Cadherin and Beta-Catenin in Cutaneous Squamous Cell Carcinoma and its Precursors

2004 ◽  
Vol 26 (5) ◽  
pp. 372-378 ◽  
Author(s):  
Anna Lyakhovitsky ◽  
Aviv Barzilai ◽  
Mina Fogel ◽  
Henri Trau ◽  
Monika Huszar
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Beta Catenin ◽  
E Cadherin

scholarly journals Prognostic and Risk Factors in Patients with Locally Advanced Cutaneous Squamous Cell Carcinoma of the Trunk and Extremities

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
de Lima Vazquez Vinicius ◽  
Cristovam Scapulatempo ◽  
Natalia Martins Perpetuo ◽  
Faheez Mohamed ◽  
Teóclito Sachetto de Carvalho ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Locally Advanced ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Primary Tumors ◽  
Node Metastasis ◽  
E Cadherin

55 patients with advanced cutaneous squamous cell carcinoma (CSCC) of the trunk and extremities were studied.A Tissue Microarraywas constructed using immunohistochemistry to quantify expression of the HER family, E-cadherins, and podoplanin. Clinical and histopathological factors related to lymph node metastasis and prognosis were also established. Primary tumor positivity was 25.5% for EGFR, 87.3% for HER-3, and 48.1% for HER-4. Metastases were positive for EGFR in 41.7%, for HER-3 in 83.3%, and HER-4 in 43.5%. HER-2 was negative in all samples. Membrane E-cadherin and cytoplasmic E-cadherin were positive in 47.3% and 30.2% of primary tumors and 45.5% and 27.3% of metastases, respectively. Podoplanin was positive in 41.8% of primary tumors and 41.7% of metastases. Intratumoral lymphocytic infiltrate was associated with lymph node metastasis. Patients with T3 tumors had better cancer-specific survival (CSS) than those with T4 tumors; patients with no lymph node involvement had better CSS than patients with N1 tumors. Undifferentiated tumors and hyperexpression of podoplanin were negative prognostic indicators on multivariate analysis.

scholarly journals Podoplanin is required for tumor cell invasion in cutaneous squamous cell carcinoma

2021 ◽  
Author(s):  
Melanie Schwab ◽  
Sabrina Lohr ◽  
Jakob Schneider ◽  
Michaela Kaiser ◽  
Damir Krunic ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Tumor Cell ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cell Invasion ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Tumor Cell Invasion

scholarly journals Cytoskeletal protein flightless I inhibits apoptosis, enhances tumor cell invasion and promotes cutaneous squamous cell carcinoma progression

Oncotarget ◽  
2015 ◽  
Vol 6 (34) ◽  
pp. 36426-36440 ◽  
Author(s):  
Zlatko Kopecki ◽  
Gink N. Yang ◽  
Jessica E. Jackson ◽  
Elizabeth L. Melville ◽  
Matthew P. Caley ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Tumor Cell ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cell Invasion ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Tumor Cell Invasion ◽  
Cytoskeletal Protein
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