scholarly journals Genetic alterations of HER genes in chromophobe renal cell carcinoma

2016 ◽  
Vol 11 (3) ◽  
pp. 2111-2116 ◽  
Author(s):  
WEN HUI WENG ◽  
YING TZU CHEN ◽  
KAI JIE YU ◽  
YING HSU CHANG ◽  
CHENG KENG CHUANG ◽  
...  
2012 ◽  
Vol 130 (1) ◽  
pp. 57-60 ◽  
Author(s):  
César Augusto Alvarenga ◽  
José Manuel Lopes ◽  
João Vinagre ◽  
Paula Itagyba Paravidino ◽  
Marcelo Alvarenga ◽  
...  

CONTEXT: Extra-adrenal paragangliomas are rare tumors that have been reported in many locations, including the kidney, urethra, urinary bladder, prostate, spermatic cord, gallbladder, uterus and vagina. CASE REPORT: This report describes, for the first time to the best of our knowledge, a primary paraganglioma of the seminal vesicle occurring in a 61-year-old male. The patient presented persistent arterial hypertension and a previous diagnosis of chromophobe renal cell carcinoma. It was hypothesized that the seminal vesicle tumor could be a metastasis from the chromophobe renal cell carcinoma. Immunohistochemical characterization revealed expression of synaptophysin and chromogranin in tumor cell nests and peripheral S100 protein expression in sustentacular cells. Succinate dehydrogenase A and B-related (SDHA and SDHB) expression was present in both tumors. CONCLUSIONS: No genetic alterations to the VHL and SDHB genes were detected in either the tumor tissue or tissues adjacent to the tumor, which led us to rule out a hereditary syndrome that could explain the association between paraganglioma and chromophobe renal cell carcinoma in a patient with arterial hypertension.


2007 ◽  
Vol 51 (1) ◽  
pp. 9-15 ◽  
Author(s):  
Javier Salamanca ◽  
Nuria Alberti ◽  
Fernando López-Ríos ◽  
Andrés Perez-Barrios ◽  
Miguel Angel Martínez-González ◽  
...  

2021 ◽  
Vol 160 ◽  
pp. 103287 ◽  
Author(s):  
Rohan Garje ◽  
Dean Elhag ◽  
Hesham A Yasin ◽  
Luna Acharya ◽  
Daniel Vaena ◽  
...  

Genes ◽  
2021 ◽  
Vol 12 (2) ◽  
pp. 261 ◽  
Author(s):  
Patrick T. Gomella ◽  
W. Linehan ◽  
Mark W. Ball

Renal cell carcinoma is a term that represents multiple different disease processes, each driven by different genetic alterations, with distinct histology, and biological potential which necessitates divergent management strategies. This review discusses the genetic alterations seen in several forms of hereditary kidney cancer and how that knowledge can dictate when and how to intervene with a focus on the surgical management of these tumors.


2004 ◽  
Vol 28 (8) ◽  
pp. 1045-1050 ◽  
Author(s):  
Kurt T Patton ◽  
Maria S Tretiakova ◽  
Jorge L Yao ◽  
Veronica Papavero ◽  
Lei Huo ◽  
...  

2013 ◽  
Vol 2013 ◽  
pp. 1-5
Author(s):  
Noureddine Bouadel ◽  
Fahd El Ayoubi ◽  
A. Anass Bennani-Baiti ◽  
Mohamed Anas Benbouzid ◽  
Leila Essakalli ◽  
...  

The metastasis of chromophobe renal cell carcinoma to head and neck region, described herein, has never been reported before to our knowledge. A 56-year-old woman with a history of nephrectomy, that revealed chromophobe renal cell carcinoma six years before, presented left cervical mass. Imaging showed with left cervical lymphadenopathies and thyroid nodule. Surgery with histopathological examination confirmed that it was a left central and lateral jugular lymph node metastasis of chromophobe renal cell carcinoma treated postoperatively by antiangiogenic therapy. The patient was successfully treated by surgery and antiangiogenic drugs with stabilization and no recurrence of the metastatic disease. The case and the literature reported here support that chromophobe renal cell carcinoma can metastasize to the head and neck region and should preferentially be treated with surgery and antiangiogenic therapy because of the associated morbidity and quality-of-life issues.


1996 ◽  
Vol 3 (5) ◽  
pp. 336 ◽  
Author(s):  
Janet R. Durham ◽  
Mary Keohane ◽  
Mahul B. Amin

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