scholarly journals A novel IGH@ gene rearrangement associated with CDKN2A/B deletion in young adult B-cell acute lymphoblastic leukemia

2016 ◽  
Vol 11 (3) ◽  
pp. 2117-2122 ◽  
Author(s):  
MONEEB A.K. OTHMAN ◽  
BEATA GRYGALEWICZ ◽  
BARBARA PIENKOWSKA-GRELA ◽  
JOLANTA RYGIER ◽  
ANNA EJDUK ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Young Adult ◽  
B Cell ◽  
Gene Rearrangement ◽  
Lymphoblastic Leukemia ◽  
Igh Gene Rearrangement ◽  
Cell Acute Lymphoblastic Leukemia

scholarly journals BCR-ABL1 gene rearrangement as a subclonal change in ETV6-RUNX1–positive B-cell acute lymphoblastic leukemia

2016 ◽  
Vol 1 (2) ◽  
pp. 132-138 ◽  
Author(s):  
Karen A. Dun ◽  
Rob Vanhaeften ◽  
Tracey J. Batt ◽  
Louise A. Riley ◽  
Giuseppe Diano ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Tyrosine Kinase ◽  
B Cell ◽  
Tyrosine Kinase Inhibitors ◽  
Gene Rearrangement ◽  
Kinase Inhibitors ◽  
Lymphoblastic Leukemia ◽  
Rare Occurrence ◽  
Key Points ◽  
Cell Acute Lymphoblastic Leukemia

Key Points BCR-ABL1 rearrangement as a subclonal change in ETV6-RUNX1–positive B-ALL is a rare occurrence not previously reported. The prognosis of this rare subclonal change has not been determined, yet inclusion of tyrosine kinase inhibitors in treatment is ubiquitous.

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