scholarly journals Nine susceptibility loci for hepatitis B virus-related hepatocellular carcinoma identified by a pilot two-stage genome-wide association study

2015 ◽  
Vol 11 (1) ◽  
pp. 624-632 ◽  
Author(s):  
LI-SHUAI QU ◽  
FEI JIN ◽  
YAN-MEI GUO ◽  
TAO-TAO LIU ◽  
RU-YI XUE ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Susceptibility Loci ◽  
Two Stage ◽  
Genome Wide ◽  
B Virus

Two-stage genome-wide association study identifies variants in CAMSAP1L1 as susceptibility loci for epilepsy in Chinese

2011 ◽  
Vol 21 (5) ◽  
pp. 1184-1189 ◽  
Author(s):  
Youling Guo ◽  
Larry W. Baum ◽  
Pak Chung Sham ◽  
Virginia Wong ◽  
Ping Wing Ng ◽  
...  
Keyword(s):  
Association Study ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Susceptibility Loci ◽  
Two Stage ◽  
Genome Wide

scholarly journals Genome-wide association study of TP53 R249S mutation in hepatocellular carcinoma with aflatoxin B1 exposure and hepatitis B virus infection in Guangxi

2020 ◽  
Author(s):  
Chuangye Han ◽  
Tingdong Yu ◽  
Wei Qin ◽  
Xiwen Liao ◽  
Jianlu Huang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Tumor Tissue ◽  
Genome Wide Association Study ◽  
Hbv Infection ◽  
Genome Wide Association ◽  
Chronic Hbv Infection ◽  
Genome Wide ◽  
B Virus ◽  
Chronic Hbv

AbstractBackground/AimsDietary aflatoxin B1 (AFB1) exposure, which induces DNA damage and codon 249 mutation of the TP53 gene, is one of the major risk factors for hepatocellular carcinoma (HCC). Hepatitis B virus (HBV) infection and AFB1 exert synergistic effects to promote carcinogenesis and TP53 R249S mutation in HCC.MethodsA genome-wide association study (GWAS) was conducted on 485 cases of HCC with chronic HBV infection, followed by a two-stage replication study on 270 cases with chronic HBV infection. Susceptibility variants for the TP53 R249S mutation in HCC were identified based on both GWAS and replication analysis. The associations of identified variants with expression levels of their located genes were validated in 20 paired independent samples.ResultsOur results showed that TP53 R249S was significantly associated with ADAMTS18 rs9930984 (adjusted P = 4.84×10−6), WDR49 rs75218075 (adjusted P = 7.36 × 10−5) and SLC8A3 rs8022091 (adjusted P = 0.042). Additionally, ADAMTS18 mRNA expression was significantly higher in HCC tissue, compared with paired non-tumor tissue (P = 0.041) and patients carrying the TT genotype at rs9930984 showed lower ADAMTS18 expression in non-tumor tissue, compared with those carrying the GT genotype (P = 0.0028).ConclusionsTP53 expression is significantly associated with R249S mutation in HCC. Our collective results suggest that rs9930984, rs75218075 and rs8022091 are associated with susceptibility to the R249S mutation in cases of HCC exposed to AFB1 and HBV infection.

scholarly journals Genome-wide association analysis identifies aGLULhaplotype for familial hepatitis B virus-related hepatocellular carcinoma

Cancer ◽  
2017 ◽  
Vol 123 (20) ◽  
pp. 3966-3976 ◽  
Author(s):  
You-Yu Lin ◽  
Ming-Whei Yu ◽  
Shi-Ming Lin ◽  
Shou-Dong Lee ◽  
Chih-Ling Chen ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Association Analysis ◽  
Genome Wide Association ◽  
Genome Wide Association Analysis ◽  
Genome Wide ◽  
B Virus
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