scholarly journals Transient pancytopenia preceding adult acute lymphoblastic leukemia with chromosomal abnormalities including the Philadelphia chromosome: A case report and review of the literature

2015 ◽  
Vol 10 (6) ◽  
pp. 3789-3792 ◽  
Author(s):  
YUN LIANG ◽  
LUYIN DING ◽  
XIAN LI ◽  
WEIQIN WANG ◽  
XIAOHONG ZHANG
Keyword(s):  
Case Report ◽  
Acute Lymphoblastic Leukemia ◽  
Chromosomal Abnormalities ◽  
Lymphoblastic Leukemia ◽  
Philadelphia Chromosome ◽  
Review Of The Literature ◽  
Adult Acute Lymphoblastic Leukemia

scholarly journals Detection of the Philadelphia chromosome in acute lymphoblastic leukemia by pulsed-field gel electrophoresis

Blood ◽  
1989 ◽  
Vol 74 (3) ◽  
pp. 1101-1107 ◽  
Author(s):  
AL Hooberman ◽  
CM Rubin ◽  
KP Barton ◽  
CA Westbrook
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Gel Electrophoresis ◽  
Chromosomal Abnormalities ◽  
Lymphoblastic Leukemia ◽  
Philadelphia Chromosome ◽  
Pulsed Field Gel Electrophoresis ◽  
Myelogenous Leukemia ◽  
Clinical Samples ◽  
Pulsed Field ◽  
Translocation Breakpoints

Abstract The Philadelphia (Ph1) chromosome is an acquired abnormality in the malignant cells of 10% to 25% of patients with acute lymphoblastic leukemia (ALL). Unlike chronic myelogenous leukemia (CML), where the molecular detection of the Ph1 chromosome is relatively straightforward using conventional Southern hybridization analysis, the detection of the Ph1 chromosome in ALL is complicated by the existence of several molecular subtypes, and the fact that translocation breakpoints are dispersed over a large genomic area. To circumvent these difficulties, we investigated pulsed-field gel electrophoresis (PFGE) to determine if this method could be used directly on clinical samples to detect the Ph1 chromosome in ALL. We report that, in a study of seven patients with Ph1-positive ALL, we could easily detect the Ph1 using only a single PFGE analysis, regardless of the Ph1 subtype, and we could confirm that the translocations occur either within or very near the BCR gene in all seven. We conclude that PFGE is a useful technique for the detection of the Ph1 in ALL, which ultimately may find wide applicability in the detection of other chromosomal abnormalities in other malignancies.

Immunophenotypes and Outcome of Philadelphia Chromosome-Positive and -Negative Thai Adult Acute Lymphoblastic Leukemia

2003 ◽  
Vol 78 (4) ◽  
pp. 337-343 ◽  
Author(s):  
Chirayu Udomsakdi-Auewarakul ◽  
Orathai Promsuwicha ◽  
Chintana Tocharoentanaphol ◽  
Chanya Munhketvit ◽  
Kovit Pattanapanyasat ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Philadelphia Chromosome ◽  
Adult Acute Lymphoblastic Leukemia ◽  
Philadelphia Chromosome Positive

scholarly journals MASSIVE PNEUMONIA AND PANCYTOPENIA LEADING TO THE DIAGNOSIS OF ACUTE LYMPHOBLASTIC LEUKEMIA IN CHILD – A CASE REPORT AND A REVIEW OF THE LITERATURE

2017 ◽  
Vol 66 (3) ◽  
pp. 186-190
Author(s):  
Lorena Elena Melit ◽  
◽  
Cristina Oana Marginean ◽  
Mihaela Ioana Chincesan ◽  
Iulia Armean ◽  
...  
Keyword(s):  
Case Report ◽  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Review Of The Literature
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