scholarly journals Autologous peripheral blood stem cell transplantation in children and adolescents with non-Hodgkin lymphoma

2015 ◽  
Vol 10 (3) ◽  
pp. 1826-1830
Author(s):  
WEI GUI ◽  
LIPING SU ◽  
JIANXIA HE ◽  
LIEYANG WANG ◽  
TAO GUAN
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Children And Adolescents ◽  
Hodgkin Lymphoma ◽  
Cell Transplantation ◽  
Peripheral Blood ◽  
Peripheral Blood Stem Cell ◽  
Blood Stem Cell ◽  
Non Hodgkin Lymphoma ◽  
Blood Stem Cell Transplantation

scholarly journals The Combination of Jiedu Xiaoluo Decoction with Autologous Peripheral Blood Stem Cell Transplantation (APBSCT) Accelerates Disease Remission of Non-Hodgkin Lymphoma

2021 ◽  
Vol 2021 ◽  
pp. 1-15
Author(s):  
Yu Zhang ◽  
Jingjing Xiang ◽  
Ni Zhu ◽  
Hangping Ge ◽  
Xianfu Sheng ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Hodgkin Lymphoma ◽  
Cell Transplantation ◽  
Peripheral Blood ◽  
Peripheral Blood Stem Cell ◽  
Migration And Invasion ◽  
Non Hodgkin Lymphoma ◽  
Blood Stem Cell Transplantation

Objective. This study aimed to explore the therapeutic effects of autologous peripheral blood stem cell transplantation (APBSCT) with Jiedu Xiaoluo decoction (JDX) on non-Hodgkin lymphoma (NHL). Method. B lymphoma cells A20 were used to establish nude mice-transplanted tumor model. The peripheral blood of mice was analyzed by automatic blood cell counter. Inflammatory cytokines in tumor tissues were measured by ELISA, real-time qRT-PCR, and western blotting assays. Immunohistochemical staining was employed to evaluate tumor cell growth and apoptosis. CCK8 and Transwell assays were used to detect cell viability, migration, and invasion. Cell apoptosis in vitro was evaluated with flow cytometry. Result. In the in vitro co-culture system of A20 cells and hemopoietic stem cells (HSC), JDX notably inhibited the proliferation, migration, and invasion and promoted apoptosis of A20 cells compared to HSC treatment alone. In animal tumor xenografts of NHL, the combination of APBSCT with JDX significantly promoted hematopoietic reconstitution, inhibited tumorigenesis of A20 cell, promoted the inflammatory microenvironment remission, inhibited cell proliferation, and promoted apoptosis compared to APBSCT alone. Conclusion. The combination of APBSCT with JDX might be an effective strategy to treat NHL through inhibiting tumorigenesis and reconstructing hematopoietic and immune microenvironment. Our finding provided a novel insight into the clinical application of Traditional Chinese Medicine (TCM) against NHL.

Evans syndrome after autologous peripheral blood stem cell transplantation for recurrent Hodgkin lymphoma

2016 ◽  
Vol 58 (9) ◽  
pp. 933-936
Author(s):  
Ikuko Kato ◽  
Hitoshi Okada ◽  
Tomoko Nishida ◽  
Yukihiko Konishi ◽  
Sonoko Kondo ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Hodgkin Lymphoma ◽  
Cell Transplantation ◽  
Peripheral Blood ◽  
Peripheral Blood Stem Cell ◽  
Blood Stem Cell ◽  
Evans Syndrome ◽  
Blood Stem Cell Transplantation
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