scholarly journals Significance of ATP-binding cassette transporter proteins in multidrug resistance of head and neck squamous cell carcinoma

2015 ◽  
Vol 10 (2) ◽  
pp. 631-636 ◽  
Author(s):  
GUO-FANG GUAN ◽  
DE-JUN ZHANG ◽  
YING ZHENG ◽  
LIAN-JI WEN ◽  
DUO-JIAO YU ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Multidrug Resistance ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Atp Binding ◽  
Transporter Proteins ◽  
Atp Binding Cassette Transporter ◽  
Atp Binding Cassette

Evaluation of drug transporters' significance for multidrug resistance in head and neck squamous cell carcinoma

Head & Neck ◽  
2010 ◽  
Vol 33 (7) ◽  
pp. 959-968 ◽  
Author(s):  
Dirk Theile ◽  
Nahal Ketabi-Kiyanvash ◽  
Christel Herold-Mende ◽  
Gerhardt Dyckhoff ◽  
Thomas Efferth ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Multidrug Resistance ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Drug Transporters ◽  
Neck Squamous Cell Carcinoma

Minor role of pregnane-x-receptor for acquired multidrug resistance in head and neck squamous cell carcinoma in vitro

2013 ◽  
Vol 71 (5) ◽  
pp. 1335-1343 ◽  
Author(s):  
Juan Pablo Rigalli ◽  
Tasmin Reuter ◽  
Christel Herold-Mende ◽  
Gerhard Dyckhoff ◽  
Walter Emil Haefeli ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Multidrug Resistance ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Pregnane X Receptor ◽  
Neck Squamous Cell Carcinoma ◽  
Minor Role

Expression of multidrug resistance-associated protein (MRP) in head and neck squamous cell carcinoma

1998 ◽  
Vol 126 (1) ◽  
pp. 89-95 ◽  
Author(s):  
Hideaki Tsuzuki ◽  
Shigeharu Fujieda ◽  
Hiroshi Sunaga ◽  
Chizuru Sugimoto ◽  
Nobuyuki Tanaka ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Multidrug Resistance ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma

MicroRNA expression profiles of head and neck squamous cell carcinoma with docetaxel-induced multidrug resistance

Head & Neck ◽  
2010 ◽  
Vol 33 (6) ◽  
pp. 786-791 ◽  
Author(s):  
Yuemeng Dai ◽  
Cheng-hui Xie ◽  
John P. Neis ◽  
Chun-Yang Fan ◽  
Emre Vural ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Multidrug Resistance ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Expression Profiles ◽  
Microrna Expression ◽  
Neck Squamous Cell Carcinoma

scholarly journals Elevated expression of Nrf2 mediates multidrug resistance in CD133+ head and neck squamous cell carcinoma stem cells

2016 ◽  
Vol 12 (6) ◽  
pp. 4333-4338 ◽  
Author(s):  
Bao-Cai Lu ◽  
Jing Li ◽  
Wen-Fa Yu ◽  
Guo-Zheng Zhang ◽  
Hui-Min Wang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Squamous Cell Carcinoma ◽  
Multidrug Resistance ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Elevated Expression

Hubungan ekspresi p53, Bcl-2, c-Myc dan MMP-9 dengan gambaran klinikopatologi karsinoma sel skuamosa kepala-leher

2016 ◽  
Vol 46 (1) ◽  
pp. 53
Author(s):  
Azwar Azwar ◽  
Sofia Mubarika ◽  
Agus Surono
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Tumor Location ◽  
Neck Squamous Cell Carcinoma ◽  
Second Primary ◽  
Cross Sectional ◽  
P53 Expression ◽  
Local Metastasis

Latar belakang: Karsinoma sel skuamosa kepala dan leher merupakan salah satu kanker terseringdi seluruh dunia. Pendekatan pengobatan agresif dan multidisiplin telah dilakukan, namun belum adapeningkatan yang signifikan dalam kelangsungan hidup 5 tahun, selama 20 tahun terakhir. Kegagalanpengobatan terjadi dalam bentuk kekambuhan lokoregional, metastasis jauh, dan/atau tumor primer kedua.Berbagai penanda molekular tumor telah diteliti untuk mengetahui potensinya dalam memprediksi hasilpenyakit atau respon terhadap terapi.Tujuan: Mengetahui hubungan ekspresi protein p53, Bcl-2, c-Myc,dan MMP-9 berdasarkan gambaran klinikopatologis karsinoma sel skuamosa kepala dan leher di RumahSakit dr. Zainoel Abidin.Metode: Studi menggunakan desain cross sectional. Sampel terdiri dari 60blok parafin karsinoma sel skuamosa kepala dan leher. Prosedur pewarnaan imunohistokimia dilakukandengan menggunakan antibodi monoklonal terhadap p53, Bcl-2, c-Myc, dan MMP-9. Ekspresi proteinp53, Bcl-2, c-Myc, dan MMP-9 dianalisis secara imunohistokimia pada karsinoma sel skuamosa kepaladan leher kemudian hasilnya dihubungkan dengan parameter klinikopatologis seperti usia, jenis kelamin,lokasi tumor, diferensiasi tumor, metastasis kelenjar getah bening dan stadium tumor, kemudian dianalisisstatistik dengan Chi square.Hasil: Hasil penelitian menunjukkan terdapat hubungan bermakna tingkatekspresi p53 dengan metastasis lokal (p=0,021) dan ada hubungan bermakna tingkat ekspresi MMP-9dengan lokasi tumor (p=0,026). Tidak terdapat hubungan ekspresi p53, Bcl-2, cMyc, dan MMP-9 terhadapusia, jenis kelamin, stadium tumor, diferensiasi histologi, tingkat T, N, dan metastasis jauh.Kesimpulan:Ada hubungan ekpresi p53 dengan metastasis kelenjar limfe regional dan ekspresi MMP-9 dengan lokasitumor pada karsinoma sel skuamosa kepala dan leher. Kata kunci: Karsinoma sel skuamosa kepala dan leher, p53, Bcl-2, c-Myc, MMP-9 ABSTRACTBackground: Head and neck squamous cell carcinoma (HNSCC) is one of the most commoncancers world wide. Although aggressive and multidisciplinary approach to the treatment has been done,there is no significant improvement in 5-year survival in the last 20 years. Treatment failure occurredin the form of locoregional recurrence, distant metastasis, and/or a second primary tumor. A variety oftumor molecular markers have been studied to determine their potential in predicting disease outcome orresponse to the therapy. Purpose: To investigate correlation p53, Bcl-2, c-Myc, and MMP-9 expressionto clinicopathologic parameter in head and neck squamous cell carcinoma patient in dr. Zainoel Abidinhospital. Methods: Cross sectional design study. The sample was consisted of 60 paraffin blocks ofhead and neck squamous cell carcinoma. Procedure of immunohistochemical staining used monoclonalantibodies against p53, Bcl-2, c-Myc, and MMP-9. Expression of p53 protein, Bcl-2, c-Myc, and MMP-9were analyzed by immunohistochemistry in head and neck squamous cell carcinoma. Then, the results were linked to clinicopathologic parameters such as age, sex, tumor location, tumor differentiation,lymph node metastasis and tumor stage, and statistically analyzed with Chi square. Results: The resultsshowed there were significant correlation between p53 expression level with local metastasis (p=0,021)and significant correlation of MMP-9 expression levels with tumor location (p=0,026). There were norelationship of p53, Bcl-2, cMyc and MMP-9 expressions based on age, sex, stage tumor, histologicdifferentiation, level of T, N, and distant metastases. Conclusion: There were relationships between p53expression with local metastasis and MMP-9 expression with tumor location in head and neck squamouscell carcinoma. Keywords: Head and neck squamous cell carcinoma, p53, Bcl-2, c-Myc, MMP-9

Sign in / Sign up

Export Citation Format

Share Document