scholarly journals Association between the MTHFR C677T polymorphism and gastric cancer susceptibility: A meta-analysis of 5,757 cases and 8,501 controls

2015 ◽  
Vol 10 (2) ◽  
pp. 1159-1165 ◽  
Author(s):  
LONG CHEN ◽  
NING LU ◽  
BAI-HONG ZHANG ◽  
LI WENG ◽  
JUN LU
Keyword(s):  
Gastric Cancer ◽  
Cancer Susceptibility ◽  
Meta Analysis ◽  
Mthfr C677t ◽  
C677t Polymorphism ◽  
Mthfr C677t Polymorphism

Decrease in gastric cancer susceptibility by MTHFR C677T polymorphism in Ardabil Province, Iran

2013 ◽  
Vol 24 (2) ◽  
pp. 117-121 ◽  
Author(s):  
S Saied HOSSEINI-ASL ◽  
Farhad POURFARZI ◽  
Abazar BARZEGAR ◽  
Mohammad MAZANI ◽  
Nima FARAHMAND ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Susceptibility ◽  
Mthfr C677t ◽  
C677t Polymorphism ◽  
Mthfr C677t Polymorphism

scholarly journals Methylenetetrahydrofolate reductase C677T polymorphism and colorectal cancer susceptibility: a meta-analysis

2017 ◽  
Vol 37 (6) ◽  
Author(s):  
Lingyan Xu ◽  
Zhiqiang Qin ◽  
Feng Wang ◽  
Shuhui Si ◽  
Lele Li ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Publication Bias ◽  
Methylenetetrahydrofolate Reductase ◽  
Cancer Susceptibility ◽  
Meta Analysis ◽  
Mthfr C677t ◽  
Control Group ◽  
C677t Polymorphism ◽  
Case Control Studies ◽  
Mthfr C677t Polymorphism

The association between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and colorectal cancer (CRC) susceptibility has been researched in numerous studies. However, the results of these studies were controversial. Therefore, the objective of this meta-analysis was to offer a more convincible conclusion about such association with more included studies. Eligible studies published till May 1, 2017 were searched from PubMed, Embase, Web of Science, and CNKI database about such association. Pooled odds ratios (ORs) together with 95% confidence intervals (CIs) were calculated to evaluate such association. And the Begg’s funnel plot and Egger’s test were applied to assess the publication bias. This meta-analysis contained 37049 cases and 52444 controls from 87 publications with 91 eligible case–control studies. Because of lack of data for a particular genotype in several studies, all the included studies were analysed barely in the dominant model. Originally, there was no association between MTHFR C677T polymorphism and CRC susceptibility (OR =0.99, 95% CI =0.94–1.05). After excluding 13 studies according to their heterogeneity and publication bias, rs1801133 polymorphism was found to reduce the risks of CRC significantly (OR =0.96, 95% CI =0.94–0.99). In the subgroup analysis of ethnicity, there was a significant association in Asians (OR =0.94, 95% CI =0.89–1.00). Furthermore, when stratified by the source of controls and genotyping methods, the positive results were observed in population-based control group (OR =0.97, 95% CI =0.93–1.00) and PCR-restriction fragment length polymorphism (PCR-RFLP) method (OR =0.95, 95% CI =0.91–0.99. The results of the meta-analysis suggested that MTHFR C677T polymorphism was associated with CRC susceptibility, especially in Asian population.

The MTHFR C677T polymorphism contributes to an increased risk for vascular dementia: A meta-analysis

2010 ◽  
Vol 294 (1-2) ◽  
pp. 74-80 ◽  
Author(s):  
Hua Liu ◽  
Min Yang ◽  
Guang-Ming Li ◽  
Ya Qiu ◽  
Jian Zheng ◽  
...  
Keyword(s):  
Vascular Dementia ◽  
Meta Analysis ◽  
Mthfr C677t ◽  
C677t Polymorphism ◽  
Mthfr C677t Polymorphism ◽  
Increased Risk

Association between MTHFR C677T polymorphism and primary open-angle glaucoma: A meta-analysis

Gene ◽  
2013 ◽  
Vol 512 (2) ◽  
pp. 179-184 ◽  
Author(s):  
Yan Huo ◽  
Huan Zou ◽  
Min Lang ◽  
Shu-Xing Ji ◽  
Xiao-Lei Yin ◽  
...  
Keyword(s):  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Meta Analysis ◽  
Mthfr C677t ◽  
Open Angle ◽  
C677t Polymorphism ◽  
Mthfr C677t Polymorphism

Effect of MTHFR C677T Polymorphism on Methylation Status of E-Cadherin in Gastric Cancer

2016 ◽  
Vol 3 (4) ◽  
Author(s):  
Ahmad Shabanizadeh ◽  
Mohammad Mohsen Taghavi ◽  
Mahdi Shariati Kohbanani ◽  
Zahra Taghipour ◽  
Hamidreza Jafarinaveh ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Methylation Status ◽  
Mthfr C677t ◽  
C677t Polymorphism ◽  
Mthfr C677t Polymorphism ◽  
E Cadherin
Sign in / Sign up

Export Citation Format

Share Document