scholarly journals Biomarkers for gastric cancer: Progression in early diagnosis and prognosis (Review)

2015 ◽  
Vol 9 (4) ◽  
pp. 1502-1508 ◽  
Author(s):  
ZILIANG JIN ◽  
WEIHUA JIANG ◽  
LIWEI WANG
Keyword(s):  
Gastric Cancer ◽  
Early Diagnosis ◽  
Cancer Progression ◽  
Diagnosis And Prognosis ◽  
Gastric Cancer Progression

scholarly journals Overexpression of SULT2B1b Promotes Angiogenesis in Human Gastric Cancer

2016 ◽  
Vol 38 (3) ◽  
pp. 1040-1054 ◽  
Author(s):  
Wen Chen ◽  
Haiyu Zhou ◽  
Lei Ye ◽  
Baogen Zhan
Keyword(s):  
Gastric Cancer ◽  
Hepatocellular Carcinoma ◽  
Endothelial Cells ◽  
Cancer Progression ◽  
Human Gastric Cancer ◽  
Qrt Pcr ◽  
Diagnosis And Prognosis ◽  
Promising Strategy ◽  
Oncogenic Protein ◽  
Gastric Cancer Progression

Background/Aims: Overexpression of cytosolic sulfotransferase 2B1b (SULT2B1b) has been commonly found in colorectal and hepatocellular carcinoma, suggesting that SULT2B1b might act as a potential oncogenic protein. However, its clinical significance and biological role in gastric cancer progression remain largely unknown. Methods: Expressions of SULT2B1b in clinical gastric cancer (GC) samples were examined using qRT-PCR and Western blot. Results: SULT2B1b was markedly overexpressed in human GC samples, and positively correlated with vessel density and associated with poor clinical features. We also demonstrated that overexpression of SULT2B1b resulted in increased tumor angiogenesis and tumor growth in mouse GC models. In addition, ablation of SULT2B1b in human GC cells lines BGC823 and MKN45 decreased the capability of the cells to recruit endothelial cells. Moreover, depletion of SULT2B1b in GC cells reduced VEGF-A expression by downregulating SP1 and AP2. Conclusion: Our results suggested that the SULT2B1b-mediated angiogenic pathway could serve as biomarkers for GC diagnosis and prognosis, and suppressing SULT2B1b-mediated angiogenic signaling might be a promising strategy for developing novel GC treatment.

scholarly journals ELK4-mediated lncRNA SNHG22 promotes gastric cancer progression through interacting with EZH2 and regulating miR-200c-3p/Notch1 axis

2021 ◽  
Author(s):  
Xiaqiong Mao ◽  
Tao Ji ◽  
Aiguo Liu ◽  
Yunqi Weng
Keyword(s):  
Gastric Cancer ◽  
Cancer Progression ◽  
Tumor Suppressor Genes ◽  
Luciferase Reporter ◽  
Diagnosis And Prognosis ◽  
Reporter Assays ◽  
Non Coding Rnas ◽  
Gastric Cancer Progression ◽  
Proliferation And Invasion

Abstract Background Long non-coding RNAs (lncRNAs) play important regulatory roles in the initiation and progression of various cancers. However, the biological roles and the potential mechanisms of lncRNAs in gastric cancers remain unclear. Methods The expression of SNHG22 in gastric cancer was analyzed in public databases (TCGA) and validated via qRT-PCR. SNHG22 knockdown cell lines were construced, and cell proliferation and invasion were analyzed. CHIP and luciferase reporter assays were performed to clarify the transcriptional role of ELK4. RNA pull-down followed MS and RIP assays were employed to identify the interaction between SNHG22 and EZH2. Luciferase reporter assays and RIP assays were used to confirm the regulation of SNHG22 on Notch1 by sponging miR-2003-3p. Results Knockdown of SNHG22 inhibited the proliferation and invasion ability of GC cells. Moreover, we identified that the transcriptional factor, ELK4, could promote SNHG22 expression in GC cells. In addition, using RNA pull-down followed MS assay, we found that SNHG22 directly bound to EZH2 to suppress the expression of tumor suppressor genes. At the same time, SNHG22 sponged miR-200c-3p to increase Notch1 expression. Conclusions Taken together, our findings demonstrated the role of SNHG22 on promoting proliferation and invasion of GC cells. And we revealed a new regulatory mechanism of SNHG22 in GC cells. SNHG22 is a promising lncRNA biomarker for diagnosis and prognosis and a potential target for GC treatment.

scholarly journals MiR-1284 suppresses gastric cancer progression by targeting EIF4A1

2019 ◽  
Vol Volume 12 ◽  
pp. 3965-3976 ◽  
Author(s):  
Weiyuan Wei ◽  
Wenlong Cao ◽  
Zexu Zhan ◽  
Linhai Yan ◽  
Yubo Xie ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Progression ◽  
Gastric Cancer Progression
Sign in / Sign up

Export Citation Format

Share Document