scholarly journals Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging: A potential utility for the evaluation of regional liver function impairment following transcatheter arterial chemoembolization

2014 ◽  
Vol 9 (3) ◽  
pp. 1191-1196 ◽  
Author(s):  
YU-DONG XIAO ◽  
RAMCHANDRA PAUDEL ◽  
HUAN LIU ◽  
BIN ZHANG ◽  
CONG MA ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Liver Function ◽  
Transcatheter Arterial Chemoembolization ◽  
Potential Utility ◽  
Resonance Imaging ◽  
Liver Function Impairment ◽  
Function Impairment ◽  
Arterial Chemoembolization ◽  
Diethylenetriamine Pentaacetic Acid

scholarly journals The feasibility of transcatheter arterial chemoembolization following radiation therapy for hepatocellular carcinoma

2021 ◽  
Vol 10 (7) ◽  
pp. 205846012110349
Author(s):  
Mostafa Hamada ◽  
Eisuke Ueshima ◽  
Takeaki Ishihara ◽  
Yutaka Koide ◽  
Takuya Okada ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Function ◽  
Transcatheter Arterial Chemoembolization ◽  
Survival Duration ◽  
High Dose ◽  
Short Term ◽  
Liver Function Impairment ◽  
Function Impairment ◽  
Short Term Mortality ◽  
Arterial Chemoembolization

Background Technological developments have led to an increased usage of external-body radiotherapy (RT) for the treatment of hepatocellular carcinoma (HCC). Transcatheter arterial chemoembolization (TACE) may be required later in patients treated with RT because of the high recurrence rate and multinodular presentation of HCC. However, despite the risk of liver function impairment, the cumulative liver damage correlated with TACE following a hepatic RT has not been adequately assessed. Purpose To evaluate the feasibility of TACE following RT for HCC. Materials and methods Sixty-seven patients with HCC who underwent TACE after RT were retrospectively evaluated between 2012 and 2018. We assessed increases in Child–Turcotte–Pugh (CTP) by ≥2 points at 1 month, the incidence of major complications, survival duration, and short-term mortality within 6 months after TACE. Furthermore, we evaluated the predictive factors for liver function impairment and short-term mortality. Results Eight patients experienced a CTP increase ≥2 points at 1 month. There were no cases of liver abscesses or bilomas. Nine patients died within 6 months following TACE. The mean liver dose (MLD) was a significant predictor of liver function impairment at 1 month ( p = 0.042). Low liver functional reserve, distant metastasis ( p = 0.037), MLD ( p = 0.046), TACE type ( p = 0.025), and TACE within 3 months following RT ( p = 0.007) were significant predictors of short-term mortality. Conclusions Despite the feasibility of TACE following RT, clinicians should pay attention to impaired pretreatment liver function, following high dose RT, and the short duration between RT and TACE.

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