scholarly journals Stromal myofibroblasts in potentially malignant and malignant lesions of the oral cavity

2014 ◽  
Vol 9 (2) ◽  
pp. 667-670 ◽  
Author(s):  
PRISCILA CAMPIONI RODRIGUES ◽  
MÁRCIA CRISTINA DA COSTA MIGUEL ◽  
SIBELE NASCIMENTO DE AQUINO ◽  
FELIPE PAIVA FONSECA ◽  
ALAN ROGER DOS SANTOS SILVA ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Potentially Malignant ◽  
Malignant Lesions

scholarly journals Detection of human papilloma virus in potentially malignant and malignant lesions of the oral cavity and a study of associated risk factors

2016 ◽  
Vol 05 (04) ◽  
pp. 179-181 ◽  
Author(s):  
B. R. Bijina ◽  
Junaid Ahmed ◽  
Nandita Shenoy ◽  
Ravikiran Ongole ◽  
Suchitra Shenoy ◽  
...  
Keyword(s):  
Risk Factors ◽  
Oral Cavity ◽  
Squamous Cell ◽  
Chi Square ◽  
Potentially Malignant ◽  
Chi Square Test ◽  
Malignant Lesions ◽  
Well Differentiated ◽  
Associated Risk Factors ◽  
Histopathological Grading

Abstract Background: Squamous cell carcinoma of the head and neck is the 6 th most frequently occurring cancer worldwide, with over 400,000 cases projected annually. Multiple factors such as tobacco, alcohol, irradiation, virus, and chronic irritants are involved in the development of oral squamous cell carcinomas (OSCCs). The most important risk factors are chronic exposure to tobacco and alcohol. Although the evidence that implicates virus is increasing, particularly (human papillomavirus [HPV]), in the carcinogenesis process, the role of virus is not well established. Aim and Objective: This study is designed to assess the presence of HPV in potentially malignant and malignant lesions of the oral cavity as well as to correlate the presence of HPV with addictive habits and histopathological grading of the disease. Materials and Methods: Biopsy samples of OSCC and potentially malignant lesions were obtained and 3, 5 μm thickness sections were cut using a microtome. The sections were collected using a sterile brush and transferred to an Eppendorf tube. DNA extraction and polymerase chain reaction for the detection of HPV were done. Results and Conclusion: The association between histopathological grading and presence of HPV was assessed using Chi-square test and the values thus obtained were found to be statistically significant. HPV was more predominantly seen in well-differentiated carcinomas and moderately differentiated carcinomas as compared to poorly differentiated carcinomas.

scholarly journals Verrucopapillary Lesions of the Oral Cavity: A Review

2020 ◽  
Vol 4 (7) ◽  
pp. RV1-RV7
Author(s):  
Sana Khaled ◽  
Santosh R. Bharadwaj ◽  
Bushra Anjum ◽  
Satyanarayana D.
Keyword(s):  
Oral Cavity ◽  
Human Papilloma Virus ◽  
Oral Mucosa ◽  
Diagnostic Approach ◽  
Diagnostic Challenge ◽  
Papilloma Virus ◽  
Histopathological Features ◽  
Potentially Malignant ◽  
Malignant Lesions

Verrucopapillary lesions are a spectrum of benign, potentially malignant and malignant lesions of the oral mucosa which usually are misdiagnosed. They pose a great diagnostic challenge mainly due to confusing terminology and also due to similar clinical and histopathological features which often makes these lesions indistinguishable from one another. The human papilloma virus (HPV) plays a important role in the pathogenesis of majority of these lesions. This review aims to summarize and highlight the key clinical and histopathological features of these lesions, and also provides a diagnostic approach to these entities.

scholarly journals The effects of topical treatment with 5-fluorouracil on potentially malignant lesions of mice oral mucosa

2015 ◽  
Vol 32 (02) ◽  
pp. 082-088
Author(s):  
G. Costa ◽  
E. Almeida ◽  
F. Cavalcanti ◽  
J. Castro
Keyword(s):  
Oral Cavity ◽  
Patient Involvement ◽  
Antineoplastic Agent ◽  
Chemotherapeutic Drugs ◽  
Cure Rate ◽  
Lingual Mucosa ◽  
Significant Difference ◽  
Potentially Malignant ◽  
Malignant Lesions ◽  
Epithelial Lesions

Abstract Introduction: The 5-fluorouracil (5-FU) discloses a cure rate greater than 90 percent in potentially malignant lesions of skin. In the oral cavity, these lesions are treat in most cases with practice surgery, which reduces the number of patient involvement by malignant lesions, not being usual treatment with chemotherapeutic drugs. The aim of this study was to evaluate the effectiveness of the antineoplastic agent 5-fluorouracil in orabase® in potentially malignant lesions of the lingual mucosa in mice. Materials and Methods: Swiss albino mice (Mus musculus) were submitted to carcinogen 4-nitroquinoline-1-oxide (4NQO), 100 μg/ml in drinking water for 8 weeks, and on developing potentially malignant lesions on the tongue, were treated daily, with topical 5-FU in orabase® at concentrations of 0.5% and 5%, for 3 weeks. The tongues were processed for analysis by light microscopy. Results: Treatment with 5-FU in orabase® was shown to be effective in the histological degree of involution of the epithelial lesions of the tongue in the treated animals (p<0.05). However, when compared, there was no statistically significant difference between the two concentrations (p>0.05). Conclusions: The 5-FU in orabase® was shown to be a feasible therapy in potentially malignant lesions of the oral cavity.

scholarly journals ROLE OF NARROW BAND IMAGING SYSTEM IN EARLY DIAGNOSIS OF POTENTIALLY MALIGNANT LESIONS OF ORAL CAVITY

2016 ◽  
Vol 3 (57) ◽  
pp. 2988-2991
Author(s):  
Laveena P Mehta ◽  
Yessukrishna Prabhakar Shetty ◽  
Sharad B Bhalekar ◽  
Yogesh G Dabholkar ◽  
Haritosh K Velankar
Keyword(s):  
Early Diagnosis ◽  
Oral Cavity ◽  
Imaging System ◽  
Narrow Band ◽  
Narrow Band Imaging ◽  
Potentially Malignant ◽  
Malignant Lesions

scholarly journals Identification of Candida in Potentially Malignant and Malignant Lesions of the Oral Cavity

2019 ◽  
Vol 4 (1) ◽  
Author(s):  
Hamideh Kadeh ◽  
Shirin Saravani ◽  
Mansoureh Parikhah Zarmehr
Keyword(s):  
Oral Cavity ◽  
Potentially Malignant ◽  
Malignant Lesions

scholarly journals Knowledge Assessment among the Fourth and Fifth Year Students on the Potentially Malignant Lesions of Oral Cavity

2020 ◽  
Vol 24 (1) ◽  
pp. 14-20
Author(s):  
Sanja Hadžić ◽  
Mirjana Gojkov-Vukelić ◽  
Enes Pašić ◽  
Arma Muharemović ◽  
Indira Mujić Jahić
Keyword(s):  
Oral Cancer ◽  
Oral Cavity ◽  
Oral Mucosa ◽  
Cross Sectional Study ◽  
Self Assessment ◽  
Cross Sectional ◽  
Increased Risk ◽  
Potentially Malignant ◽  
Malignant Lesions ◽  
The Difference

SummaryBackground/Aim: Potentially malignant oral lesions (PMOL) are lesions that have an increased risk of malignant transformation concerning healthy oral mucosa. This research aimed to assess the knowledge of students of final years of study on the potentially malignant lesions of the oral cavity.Material and Methods: 120 students of the fourth and fifth years of study participated in this research,60 respondents were fourth-year students, 60 respondents were fifth-year students. All of the respondents signed informed consent.According to the type of research, this is a cross-sectional study which was conducted by completing a 15-item questionnaire. The results were statistically analyzed and processed in the SPSS Statistics 21.0 program.Results: The results indicate that during the clinical examination the fourth and fifth-year students examine the oral mucosa as well. 61% of the students find themselves poorly informed on the PMOL. In the fourth year of study, only 5,5% of students responded that they were well informed, while in the fifth year that number totaled 28,5%. When knowledge self-assessment is concerned the difference has shown itself to be statistically significant between the fourth and fifth-year students. When asked what knowledge on the prevention of oral cancer they expect to receive during their studies, 78% of the students expected more knowledge than at that moment – 36% of which were fifth-year students, and 42% were fourth-year students.Conclusions: Even though the oral cavity is easily accessible to examination, the discovery of oral cancer occurs quite late. Ours, as well as results of other studies, impose the need for better theoretical and practical education of the students.

Sign in / Sign up

Export Citation Format

Share Document