scholarly journals Long non-coding RNA PVT1 is associated with tumor progression and predicts recurrence in hepatocellular carcinoma patients

2014 ◽  
Vol 9 (2) ◽  
pp. 955-963 ◽  
Author(s):  
CHAOFENG DING ◽  
ZHE YANG ◽  
ZHEN LV ◽  
CHENGLI DU ◽  
HENG XIAO ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Tumor Progression ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals Long non-coding RNA CARLo-5 promotes tumor progression in hepatocellular carcinoma via suppressing miR-200b expression

Oncotarget ◽  
2017 ◽  
Vol 8 (41) ◽  
pp. 70172-70182 ◽  
Author(s):  
Chunqing Dou ◽  
Liyuan Sun ◽  
Xin Jin ◽  
Mingming Han ◽  
Bao Zhang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Tumor Progression ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals The long non-coding RNA AK023948 enhances tumor progression in hepatocellular carcinoma

2017 ◽  
Vol 14 (4) ◽  
pp. 3658-3664 ◽  
Author(s):  
Bailiang Ye ◽  
Bingren Hu ◽  
Zhihai Zheng ◽  
Ru Zheng ◽  
Yixiong Shi
Keyword(s):  
Hepatocellular Carcinoma ◽  
Tumor Progression ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals Long non-coding RNA-based signature for predicting prognosis of hepatocellular carcinoma

Bioengineered ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 673-681
Author(s):  
Jie Cao ◽  
Lili Wu ◽  
Xin Lei ◽  
Keqing Shi ◽  
Liang Shi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Non Coding Rna ◽  
Long Non Coding Rna

Long non-coding RNA UCA1 regulates the expression of Snail2 by miR-203 to promote hepatocellular carcinoma progression

2017 ◽  
Vol 143 (6) ◽  
pp. 981-990 ◽  
Author(s):  
Ji-Nan Xiao ◽  
Ting-Hua Yan ◽  
Rui-Ming Yu ◽  
Yi Gao ◽  
Wen-Long Zeng ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Non Coding Rna ◽  
Long Non Coding Rna

A long non-coding RNA-based signature predicts early recurrence in hepatocellular carcinoma

2021 ◽  
pp. 1-10
Author(s):  
Shuai He ◽  
Jin-Feng Li ◽  
Hao Tian ◽  
Ye Sang ◽  
Xiao-Jing Yang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Curative Resection ◽  
Risk Model ◽  
Cox Regression ◽  
Early Recurrence ◽  
Support Vector ◽  
Term Survival ◽  
Cox Regression Analysis ◽  
Non Coding Rna ◽  
Long Non Coding Rna

BACKGROUND: Early recurrence is the main obstacle for long-term survival of hepatocellular carcinoma (HCC) patients after curative resection. OBJECTIVE: We aimed to develop a long non-coding RNA (lncRNA) based signature to predict early recurrence. METHODS: Using bioinformatics analysis and quantitative reverse transcription PCR (RT-qPCR), we screened for lncRNA candidates that were abnormally expressed in HCC. The expression levels of candidate lncRNAs were analyzed in HCC tissues from 160 patients who underwent curative resection, and a risk model for the prediction of recurrence within 1 year (early recurrence) of HCCs was constructed with linear support vector machine (SVM). RESULTS: A lncRNA-based classifier (Clnc), which contained nine differentially expressed lncRNAs including AF339810, AK026286, BC020899, HEIH, HULC, MALAT1, PVT1, uc003fpg, and ZFAS1 was constructed. In the test set, this classifier reliably predicted early recurrence (AUC, 0.675; sensitivity, 72.0%; specificity, 63.1%) with an odds ratio of 4.390 (95% CI, 2.120–9.090). Clnc showed higher accuracy than traditional clinical features, including tumor size, portal vein tumor thrombus (PVTT) in predicting early recurrence (AUC, 0.675 vs 0.523 vs 0.541), and had much higher sensitivity than Barcelona Clinical Liver Cancer (BCLC; 72.0% vs 50.0%), albeit their AUCs were comparable (0.675 vs 0.678). Moreover, combining Clnc with BCLC significantly increased the AUC, compared with Clnc or BCLC alone in predicting early recurrence (all P< 0.05). Finally, logistic and Cox regression analysis suggested that Clnc was an independent prognostic factor and associated with the early recurrence and recurrence-free survival of HCC patients after resection, respectively (all P= 0.001). CONCLUSIONS: Our lncRNA-based classifier Clnc can predict early recurrence of patients undergoing surgical resection of HCC.

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