scholarly journals Long intergenic non-coding RNA induced by X-ray irradiation regulates DNA damage response signaling in the human bronchial epithelial BEAS-2B cell line

2014 ◽  
Vol 9 (1) ◽  
pp. 169-176 ◽  
Author(s):  
YANG JIAO ◽  
CHANG LIU ◽  
FENG-MEI CUI ◽  
JIA-YING XU ◽  
JIAN TONG ◽  
...  
Keyword(s):  
Dna Damage ◽  
Cell Line ◽  
Dna Damage Response ◽  
Bronchial Epithelial ◽  
X Ray ◽  
Non Coding Rna ◽  
Damage Response

scholarly journals DNA damage response induces structural alterations in histone H3–H4

2017 ◽  
Vol 58 (1) ◽  
pp. 59-65 ◽  
Author(s):  
Yudai Izumi ◽  
Kentaro Fujii ◽  
Satoshi Yamamoto ◽  
Koichi Matsuo ◽  
Hirofumi Namatame ◽  
...  
Keyword(s):  
Dna Damage ◽  
Chromatin Remodeling ◽  
Dna Damage Response ◽  
Histone H3 ◽  
Structural Alteration ◽  
Histone H2a ◽  
Structural Alterations ◽  
X Ray ◽  
Damage Response ◽  
Α Helix

Abstract Synchrotron-radiation circular-dichroism spectroscopy was used to reveal that the DNA damage response induces a decrement of α-helix and an increment of β-strand contents of histone H3–H4 extracted from X-ray–irradiated human HeLa cells. The trend of the structural alteration was qualitatively opposite to that of our previously reported results for histone H2A–H2B. These results strongly suggest that histones share roles in DNA damage responses, particularly in DNA repair processes and chromatin remodeling, via a specific structural alteration of each histone.

scholarly journals Home and Away: The Role of Non-Coding RNA in Intracellular and Intercellular DNA Damage Response

Genes ◽  
2021 ◽  
Vol 12 (10) ◽  
pp. 1475
Author(s):  
Annabelle Shaw ◽  
Monika Gullerova
Keyword(s):  
Dna Damage ◽  
Dna Damage Response ◽  
Therapeutic Potential ◽  
Dna Breaks ◽  
Double Strand Dna Breaks ◽  
Non Coding Rna ◽  
Damage Response ◽  
Recent Developments ◽  
Vital Component ◽  
Long Non Coding Rna

Non-coding RNA (ncRNA) has recently emerged as a vital component of the DNA damage response (DDR), which was previously believed to be solely regulated by proteins. Many species of ncRNA can directly or indirectly influence DDR and enhance DNA repair, particularly in response to double-strand DNA breaks, which may hold therapeutic potential in the context of cancer. These include long non-coding RNA (lncRNA), microRNA, damage-induced lncRNA, DNA damage response small RNA, and DNA:RNA hybrid structures, which can be categorised as cis or trans based on the location of their synthesis relative to DNA damage sites. Mechanisms of RNA-dependent DDR include the recruitment or scaffolding of repair factors at DNA break sites, the regulation of repair factor expression, and the stabilisation of repair intermediates. DDR can also be communicated intercellularly via exosomes, leading to bystander responses in healthy neighbour cells to generate a population-wide response to damage. Many microRNA species have been directly implicated in the propagation of bystander DNA damage, autophagy, and radioresistance, which may prove significant for enhancing cancer treatment via radiotherapy. Here, we review recent developments centred around ncRNA and their contributions to intracellular and intercellular DDR mechanisms.

scholarly journals RAP1/TERF2IP—A Multifunctional Player in Cancer Development

Cancers ◽  
2021 ◽  
Vol 13 (23) ◽  
pp. 5970
Author(s):  
Anna Deregowska ◽  
Maciej Wnuk
Keyword(s):  
Dna Damage ◽  
Dna Damage Response ◽  
Cell Metabolism ◽  
Expression Patterns ◽  
Cancer Development ◽  
Cellular Processes ◽  
Human Cancers ◽  
Non Coding Rna ◽  
Damage Response

Mammalian RAP1 (TERF2IP), the most conserved shelterin component, plays a pleiotropic role in the regulation of a variety of cellular processes, including cell metabolism, DNA damage response, and NF-κB signaling, beyond its canonical telomeric role. Moreover, it has been demonstrated to be involved in oncogenesis, progression, and chemoresistance in human cancers. Several mutations and different expression patterns of RAP1 in cancers have been reported. However, the functions and mechanisms of RAP1 in various cancers have not been extensively studied, suggesting the necessity of further investigations. In this review, we summarize the main roles of RAP1 in different mechanisms of cancer development and chemoresistance, with special emphasis on the contribution of RAP1 mutations, expression patterns, and regulation by non-coding RNA, and briefly discuss telomeric and non-telomeric functions.

scholarly journals Overexpression of B‐cell lymphoma 6 alters gene expression profile in a myeloma cell line and is associated with decreased DNA damage response

2017 ◽  
Vol 108 (8) ◽  
pp. 1556-1564 ◽  
Author(s):  
Kenichi Tahara ◽  
Makiko Takizawa ◽  
Arito Yamane ◽  
Yohei Osaki ◽  
Takuma Ishizaki ◽  
...  
Keyword(s):  
Gene Expression ◽  
Dna Damage ◽  
B Cell ◽  
Cell Line ◽  
Dna Damage Response ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Myeloma Cell ◽  
Myeloma Cell Line ◽  
Damage Response

scholarly journals DNA damage and DNA damage response in human bronchial epithelial BEAS-2B cells following exposure to 2-nitrobenzanthrone and 3-nitrobenzanthrone: role in apoptosis

Mutagenesis ◽  
2011 ◽  
Vol 26 (6) ◽  
pp. 697-708 ◽  
Author(s):  
E. Oya ◽  
J. Ovrevik ◽  
V. M. Arlt ◽  
E. Nagy ◽  
D. H. Phillips ◽  
...  
Keyword(s):  
Dna Damage ◽  
Dna Damage Response ◽  
Bronchial Epithelial ◽  
Damage Response
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